Engineering Commons^™

Characterization Of Changes In Hyaluronan Following Epidermal Barrier Injury In An Organotypic Model, Gati Ajani

ETD Archive

The stratum corneum, the outermost layer of the epidermis of skin, provides a functional permeability barrier that is essential for our survival and must be rapidly repaired after injury. Of interest to us, a ubiquitous matrix molecule called hyaluronan (HA) has come to the forefront in wound healing research because it is induced after epidermal injury and may be crucial for barrier repair. This thesis examines the role of HA during recovery from the most fundamental form of skin injury, i.e. selective damage to the stratum corneum. The overall question is whether this form of stratum corneum injury can lead …