Engineering Commons^™

Decellularization Of Porcine Cartilage Promotes Chondrogenic Differentiation Of Human Chondrocytes, Roxanne Nicole Stone

Boise State University Theses and Dissertations

Knee osteoarthritis (knee OA) is the most common type of osteoarthritis (OA) and accounts for 70% of arthritis-related hospital admissions and 23% of clinical visits. Major limitations in both the current non-surgical and surgical methods are that they only relieve pain and show no evidence for restoring natural tissue anatomy. Leaders in the field propose that a stem cell treatment approach holds promise for the regeneration of a greater proportion of hyaline-like tissue at the repair site. (Cross et al., 2014; Escobar Ivirico, Bhattacharjee, Kuyinu, Nair, & Laurencin, 2017; Helmick et al., 2008; Toh, Foldager, Pei, & Hui, 2014).

It …

Bi-Directional Fatigue Life Behavior Of Bovine Meniscus, Jaremy Creechley

Boise State University Theses and Dissertations

Meniscal injuries due to tissue tearing are prevalent in the U.S. yet the failure behavior of the meniscus is poorly understood. Clinical studies indicate that fatigue failure causes many of these tears. The highly circumferentially aligned fibers result in transversely isotropic material properties. Tears preferentially align bi-directionally to the fiber orientation. The aim of this study is to present the bi-directional fatigue life behavior of meniscal fibrocartilage. A novel fatigue life approach was developed to achieve this aim. Forty-eight bovine specimens were subjected to cyclic sinusoidal tension-tension stress at 2 Hz until rupture. Normalized peak tensile stresses were determined at …