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Full-Text Articles in Engineering
Phosphine Oxide Containing Poly(Pyridinium Salt)S As Fire Retardant Materials, Maksudul M. Alam, Bidyut Biswas, Alexi K. Nedeltchev, Haesook Han, Asanga D. Ranasinghe, Pradip K. Bhowmik, Kisholoy Goswami
Phosphine Oxide Containing Poly(Pyridinium Salt)S As Fire Retardant Materials, Maksudul M. Alam, Bidyut Biswas, Alexi K. Nedeltchev, Haesook Han, Asanga D. Ranasinghe, Pradip K. Bhowmik, Kisholoy Goswami
Chemistry and Biochemistry Faculty Research
Six new rugged, high-temperature tolerant phosphine oxide-containing poly(4,4′-(p-phenylene)-bis(2,6-diphenylpyridinium)) polymers P-1, P-2, P-3, P-4, P-5, and P-6 are synthesized, characterized, and evaluated. Synthesis results in high yield and purity, as confirmed by elemental, proton (1H), and carbon 13 (13C) nuclear magnetic resonance (NMR) spectra analyses ... See full text for complete abstract.
Optimization Of Protein-Protein Interaction Measurements For Drug Discovery Using Afm Force Spectroscopy, Yongliang Yang, Bixi Zeng, Zhiyong Sun, Amir Monemianesfahani, Jing Hou, Nian-Dong Jiao, Lianqing Liu, Liangliang Chen, Marc D. Basson, Lixin Dong, Ruiguo Yang, Ning Xi
Optimization Of Protein-Protein Interaction Measurements For Drug Discovery Using Afm Force Spectroscopy, Yongliang Yang, Bixi Zeng, Zhiyong Sun, Amir Monemianesfahani, Jing Hou, Nian-Dong Jiao, Lianqing Liu, Liangliang Chen, Marc D. Basson, Lixin Dong, Ruiguo Yang, Ning Xi
Department of Mechanical and Materials Engineering: Faculty Publications
Increasingly targeted in drug discovery, protein-protein interactions challenge current high throughput screening technologies in the pharmaceutical industry. Developing an effective and efficient method for screening small molecules or compounds is critical to accelerate the discovery of ligands for enzymes, receptors and other pharmaceutical targets. Here, we report developments of methods to increase the signal-to-noise ratio (SNR) for screening protein-protein interactions using atomic force microscopy (AFM) force spectroscopy. We have demonstrated the effectiveness of these developments on detecting the binding process between focal adhesion kinases (FAK) with protein kinase B (Akt1), which is a target for potential cancer drugs. These developments …