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Ultrastructural Assessment Of Lesion Development In The Collared Rabbit Carotid Artery Model, J. E. Beesley, A. C. Honey, J. F. Martin
Ultrastructural Assessment Of Lesion Development In The Collared Rabbit Carotid Artery Model, J. E. Beesley, A. C. Honey, J. F. Martin
Cells and Materials
Cellular reactions associated with the formation of lesions generated in the carotid artery of rabbits fed either normal or high cholesterol diets by the placement of a flexible, silastic collar around the artery, were studied by electron microscopy.
Endothelial cells remained as a monolayer throughout lesion development. The endothelial cell surface in both experimental and sham operated carotids, 4 hours and 8 hours after the initiation of the experiments, were covered with platelets and leukocytes. Neutrophils were present until 7 days in the arteries from within the collar of animals maintained on a normal diet, but only to 1 day …