Engineering Commons^™

Design And Validation Of Pressure Based Flow Rate Soft Sensor For Freeze-Drying, Pasita Pibulchinda, Tong Zhu, Vaibhav Kshirsagar, Alina A. Alexeenko

The Summer Undergraduate Research Fellowship (SURF) Symposium

Lyophilization or freeze drying is a process of removing water by sublimation. It is commonly used to extend the shelf life of drugs in the pharmaceutical industry. Because the process is costly and time consuming, precise and efficient pressure, temperature control and drying time estimation are required. It is the goal of freeze-drying to run at maximum capacity while staying within the safe zone by carefully controlling the sublimation rate. Currently, real time estimation of sublimation rate is still challenging. The technique available called Tunable diode laser absorption spectroscopy (TDLAS) is invasive, and requires major modifications. The current study focuses …