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Full-Text Articles in Engineering
Thin-Film Sol-Gel As Controlled Delivery Platform For Neural Microelectrodes, Margaret A. Harden, Matthew D. Mcdermott, Kevin J. Otto
Thin-Film Sol-Gel As Controlled Delivery Platform For Neural Microelectrodes, Margaret A. Harden, Matthew D. Mcdermott, Kevin J. Otto
The Summer Undergraduate Research Fellowship (SURF) Symposium
Long-term efficacy of neural implantation devices is a persisting challenge in neural engineering and rehabilitation. Upon implantation of a neural device, the foreign body response (FBR) is triggered and glial cells form a sheath around the electrode array. This sheath isolates the array from the rest of the brain both mechanically and electrically. Tetramethyl orthosilicate (TMOS), a thin-film polymer, has been shown to not negatively impact the impedance and charge-carrying capacity, as well as offer a controlled delivery method to deliver pharmaceuticals to mitigate inflammation without significant effect to device design. Using an in vitro protein delivery model to analyze …
Chronic Brain Stimulation Using Micro-Ecog Devices, Hayden C. Carney, Roy Lycke, Kevin J. Otto, Amelia A. Schendel, Justin Williams
Chronic Brain Stimulation Using Micro-Ecog Devices, Hayden C. Carney, Roy Lycke, Kevin J. Otto, Amelia A. Schendel, Justin Williams
The Summer Undergraduate Research Fellowship (SURF) Symposium
Recording and stimulating brain activity has had great success both as a research tool and as a clinical technique. Neural prosthetics can replace limbs, restore hearing, and treat disorders like Parkinson’s and epilepsy, but are relatively crude. Current neural prosthetic systems use penetrating electrodes to achieve high precision, but the invasive nature of these devices provoke a strong immune response that limits chronic use. (Polikov et al) In our study we evaluate micro-electrocortiographic (micro-ECoG) devices which sit under the skull and on the surface of the brain for stimulation over chronic timescales. We anticipate these devices with their less invasive …
Medical Applications Of Mrc, Kyle Thackston, Henry Mei, Pedro Irazoqui
Medical Applications Of Mrc, Kyle Thackston, Henry Mei, Pedro Irazoqui
The Summer Undergraduate Research Fellowship (SURF) Symposium
Consistent powering is a limiting reagent for many medical implants and sensors. Powering in-vivo devices in animal studies requires either transcutaneous wiring (limiting mobility and increasing the chance of infection) or an implanted battery (limited lifetime and limits size of device). Wireless power transfer (WPT) would be able to overcome these challenges and permit the use of more advanced implantable devices in a research setting. Magnetic resonance coupling (MRC), an advanced form of inductive charging, allows good transfer efficiencies over significant air gaps, but works best a specific location and frequency, limiting mobility in animal studies. Using band-pass filter theory, …