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Process For Formation Of Cationic Poly (Lactic-Co-Glycolic Acid) Nanoparticles Using Static Mixers, Yamuna Reddy Charabudla
Process For Formation Of Cationic Poly (Lactic-Co-Glycolic Acid) Nanoparticles Using Static Mixers, Yamuna Reddy Charabudla
University of Kentucky Master's Theses
Nanoparticles have received special attention over past few years as potential drug carriers for proteins/peptides and genes. Biodegradable polymeric poly (lactic-co-glycolic acid) (PLGA) nanoparticles are being employed as non-viral gene delivery systems for DNA. This work demonstrates a scalable technology for synthesis of nanoparticles capable of gene delivery. Cationic PLGA nanoparticles are produced by emulsiondiffusion- evaporation technique employing polyvinyl alcohol (PVA) as stabilizer and chitosan chloride for surface modification. A sonicator is used for the emulsion step and a static mixer is used for dilution in the diffusion step of the synthesis. A static mixer is considered ideal for the …