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Synthesis Of Clickable Poly(Ethylene Glycol) Derivatives For Fabrication Of Modular Microsphere-Based Scaffolds To Promote Vascularization, Peter Nguyen
McKelvey School of Engineering Theses & Dissertations
Vascularization plays an important role in supporting transplanted tissues and cells in tissue engineering applications. Most tissues require access to blood vessels for the delivery of oxygen and nutrients, as well as the removal of carbon dioxide and cellular waste products. Without an adequate blood supply, cells within tissue-engineered constructs and scaffolds lose viability and fail to perform their intended functions. The goal of this dissertation was to design scaffolds that can promote vascularization of biomaterial implants for biomedical applications. In order to accomplish this goal, clickable poly(ethylene glycol) (PEG) derivatives were synthesized in order to fabricate modular microsphere-based scaffolds …