Engineering Commons^™

Fluid Agitation Studies For Drug Product Containers Using Computational Fluid Dynamics, Matthew Hiroki Ichinose

Master's Theses

At Amgen, the Automated Vision Inspection (AVI) systems capture the movement of unwanted particles in Amgen's drug product containers. For quality inspection, the AVI system must detect these undesired particles using a high speed spin-stop agitation process. To better understand the fluid movements to swirl the particles away from the walls, Computational Fluid Dynamics (CFD) is used to analyze the nature of the two phase flow of air and a liquid solution.

Several 2-D and 3-D models were developed using Fluent to create simulations of Amgen's drug product containers for a 1 mL syringe, 2.25 mL syringe, and a 5 …

Computational Validation Of Aerodynamic Paramenters On A Multi-Sided Cylinder, Christopher Ong

Master's Theses

There are fundamental problems in fluid dynamics. One common problem is fluid flow around cylinder-shaped bodies which range from circular to multi-sided polygons. These basic geometric shapes are found in various applications. With the increased availability of computational power, the use of Computational Fluid Dynamics (CFD) becomes an avenue for studying fluid flow around theses shapes. The fluid flow over cylindrical bodies is a widely studied problem used to validate the accuracy and reliability of CFD codes before working on more complex engineering problems. This validation is done by comparing selected flow parameters to experimental results to determine the accuracy …