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Full-Text Articles in Engineering
Tissue Specific Shrna Delivery: A Novel Approach For Gene Therapy In Cancer, Shilenath Ghatak, Viacent Hascall, Franklin Berger, Maria Penas, Celestia Davis, Esmaiel Jabbari, Xuezhong He, James Norris, Yujing Dan, Roger Markwaid, Suniti Misra
Tissue Specific Shrna Delivery: A Novel Approach For Gene Therapy In Cancer, Shilenath Ghatak, Viacent Hascall, Franklin Berger, Maria Penas, Celestia Davis, Esmaiel Jabbari, Xuezhong He, James Norris, Yujing Dan, Roger Markwaid, Suniti Misra
Esmaiel Jabbari
No abstract provided.
Three-Dimensional Engineered Matrix To Study Cancer Stem Cells And Tumorsphere Formation: Effect Of Matrix Modulus, Xiaoming Yang, Samaneh Sarvestani, Seyedsina Moeinzadeh, Xuezhong He, Esmaiel Jabbari
Three-Dimensional Engineered Matrix To Study Cancer Stem Cells And Tumorsphere Formation: Effect Of Matrix Modulus, Xiaoming Yang, Samaneh Sarvestani, Seyedsina Moeinzadeh, Xuezhong He, Esmaiel Jabbari
Esmaiel Jabbari
Maintenance of cancer stem cells (CSCs) is regulated by the tumor microenvironment. Synthetic hydrogels provide the flexibility to design three-dimensional (3D) matrices to isolate and study individual factors in the tumor microenvironment. The objective of this work was to investigate the effect of matrix modulus on tumorsphere formation by breast cancer cells and maintenance of CSCs in an inert microenvironment without the interference of other factors. In that regard, 4T1 mouse breast cancer cells were encapsulated in inert polyethylene glycol diacrylate hydrogels and the effect of matrix modulus on tumorsphere formation and expression of CSC markers was investigated. The gel …