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Surface Functionalization And Bioconjugation Of Nanoparticles For Biomedical Applications, Longyan Chen
Surface Functionalization And Bioconjugation Of Nanoparticles For Biomedical Applications, Longyan Chen
Electronic Thesis and Dissertation Repository
Colloidal inorganic nanoparticles (NPs) have been attracting considerable interest in biomedicine, from drug and gene delivery to imaging, sensing and diagnostics. It is essential to modify the surface of nanoparticles to have enhanced biocompatibility and functionality for the in vitro and in vivo applications, especially in delivering locally and recognizing biomolecules. Herein, the goal of this research work is to develop advanced NPs with well-tailored surface functionalities and/or bio-functionality for the applications in cell tracking and analytes detection.
In the first project, quantum dots incorporating with gelatin nanoparticles (QDs-GNPs) have been developed for bioimaging applications. Two different approaches have been …
Fabricating Cost-Effective Nanostructures For Biomedical Applications, Erden Ertorer
Fabricating Cost-Effective Nanostructures For Biomedical Applications, Erden Ertorer
Electronic Thesis and Dissertation Repository
In this thesis we described inexpensive alternatives to fabricate nanostructures on planar substrates and provided example applications to discuss the efficiency of fabricated nanostructures.
The first method we described is forming large area systematically changing multi-shape nanoscale structures on a chip by laser interference lithography. We analyzed the fabricated structures at different substrate positions with respect to exposure time, exposure angle and associated light intensity profile. We presented experimental details related to the fabrication of symmetric and biaxial periodic nanostructures on photoresist, silicon surfaces, and ion-milled glass substrates. Behavior of osteoblasts and osteoclasts on the nanostructures was investigated. These results …