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Deep Learning Nuclei Detection In Digitized Histology Images By Superpixels, Sudhir Sornapudi, R. Joe Stanley, William V. Stoecker, Haidar Almubarak, Rodney Long, Sameer Antani, George Thoma, Rosemary Zuna, Shelliane R. Frazier
Deep Learning Nuclei Detection In Digitized Histology Images By Superpixels, Sudhir Sornapudi, R. Joe Stanley, William V. Stoecker, Haidar Almubarak, Rodney Long, Sameer Antani, George Thoma, Rosemary Zuna, Shelliane R. Frazier
Electrical and Computer Engineering Faculty Research & Creative Works
Background: Advances in image analysis and computational techniques have facilitated automatic detection of critical features in histopathology images. Detection of nuclei is critical for squamous epithelium cervical intraepithelial neoplasia (CIN) classification into normal, CIN1, CIN2, and CIN3 grades.
Methods: In this study, a deep learning (DL)-based nuclei segmentation approach is investigated based on gathering localized information through the generation of superpixels using a simple linear iterative clustering algorithm and training with a convolutional neural network.
Results: The proposed approach was evaluated on a dataset of 133 digitized histology images and achieved an overall nuclei detection (object-based) accuracy of 95.97%, with …