Engineering Commons^™

An Explainable And Statistically Validated Ensemble Clustering Model Applied To The Identification Of Traumatic Brain Injury Subgroups, Dacosta Yeboah, Louis Steinmeister, Daniel B. Hier, Bassam Hadi, Donald C. Wunsch, Gayla R. Olbricht, Tayo Obafemi-Ajayi

Electrical and Computer Engineering Faculty Research & Creative Works

We present a framework for an explainable and statistically validated ensemble clustering model applied to Traumatic Brain Injury (TBI). The objective of our analysis is to identify patient injury severity subgroups and key phenotypes that delineate these subgroups using varied clinical and computed tomography data. Explainable and statistically-validated models are essential because a data-driven identification of subgroups is an inherently multidisciplinary undertaking. In our case, this procedure yielded six distinct patient subgroups with respect to mechanism of injury, severity of presentation, anatomy, psychometric, and functional outcome. This framework for ensemble cluster analysis fully integrates statistical methods at several stages of …