Engineering Commons^™

Thermodynamics And Kinetics Of Dna Nanotube Polymerization From Single-Filament Measurements, Rizal F. Hariadi, Bernard Yurke, Erik Winfree

Electrical and Computer Engineering Faculty Publications and Presentations

DNA nanotubes provide a programmable architecture for molecular self-assembly and can serve as model systems for one-dimensional biomolecular assemblies. While a variety of DNA nanotubes have been synthesized and employed as models for natural biopolymers, an extensive investigation of DNA nanotube kinetics and thermodynamics has been lacking. Using total internal reflection microscopy, DNA nanotube polymerization was monitored in real time at the single filament level over a wide range of free monomer concentrations and temperatures. The measured polymerization rates were subjected to a global nonlinear fit based on polymerization theory in order to simultaneously extract kinetic and thermodynamic parameters. For …

Template Generation From Postmarks Using Cascaded Unsupervised Learning, Elisa H. Barney Smith, Gernot Fink

Electrical and Computer Engineering Faculty Publications and Presentations

Information in historical datasets comes in many forms. We are working with a set of World War I era postcards that contain hand written text, some preprinted text, postage stamps and postmark/cancellation stamps. The postmarks are of considerable interest to collectors looking for images of samples they had not previously seen. The postmarks also provide information on the originating location of the card that complements the information in the address block.

The postmarks vary considerably with towns and dates, but also styles. The styles can be grouped into categories. A method for automatically extracting templates for each category of these …