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Dissertations

Biomedical Engineering and Bioengineering

2019

Brain stimulation

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Modulation Of Corticospinal Excitability Induced By Paired Associative Stimulation Combined With Movement, Ahmad O. Alokaily Aug 2019

Modulation Of Corticospinal Excitability Induced By Paired Associative Stimulation Combined With Movement, Ahmad O. Alokaily

Dissertations

An essential feature of the brain is its capacity to undergo long-lasting morphological or functional changes in response to experiences or trauma. Advances in noninvasive brain stimulation techniques have led to increased interest in understanding neural mechanisms of neuroplasticity at the network level. Paired associative stimulation (PAS) is one of the most commonly used applications for noninvasive brain stimulation because of its clinical potential as an adjuvant rehabilitative intervention. However, the optimal method for incorporating PAS into rehabilitative activities remains unknown. This dissertation explores different approaches to combining PAS with movement and investigates the enhancement of the specificity of conventional …