Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 12 of 12
Full-Text Articles in Engineering
Chondroitin Sulfate Hydrogels For Total Wound Care Devices, Tushar Goswami
Chondroitin Sulfate Hydrogels For Total Wound Care Devices, Tushar Goswami
Browse all Theses and Dissertations
Chondroitin sulfate (CS) is a naturally occurring bio-polymer found in areas of high cartilage in mammals. In directed applications, such as hydrogels, CS can be used to impact keratinocyte growth cycles. In this work, CS based hydrogels were utilized to accelerate wound healing and, in conjunction with a graphene sensor, monitor wound fluid pH. The hydrogels were cast onto a graphene field effect transistor (GFET) to obtain the benefits of the hydrogel wound healing capabilities, while also utilizing the pH sensitivity of the graphene. Results showed that the hydrogel caused a fivefold increase in cell size over the course of …
Retail Facility Layout Considering Shopper Path And Door Placement, Sagarkumar D. Hirpara
Retail Facility Layout Considering Shopper Path And Door Placement, Sagarkumar D. Hirpara
Browse all Theses and Dissertations
The physical design of a retail store is known to influence the attitude and behavior of shoppers, in turn affecting the store’s performance. While literature in retail design has alluded to the impact of changes in department placements on impulse revenue, it has not accounted for the changes in the path of a shopper due to such modifications. Shopper path changes can alter a department’s visibility to the shoppers as they pass by, and such visibility eventually impacts that department’s impulse revenue. To address this gap, we study the retail facility layout problem by accounting for changes in the shopper …
Mechanical Stresses On Nasal Mucosa Using Nose-On-Chip Model, Zachary Edward Brooks
Mechanical Stresses On Nasal Mucosa Using Nose-On-Chip Model, Zachary Edward Brooks
Browse all Theses and Dissertations
The objective of this research was to design and fabricate a nose-on-chip device and bi-directional airflow system that models flow within the nasal cavity to investigate how airflow induced mechanical stresses impact nasal secretion rates and cytoskeletal remodeling. This research hypothesizes that the airflow induced shear stresses on the nasal mucosa will influence mucus production and the cytoskeleton of the cells. The RPMI 2650 cell line was used to model the nasal mucosa. The system was used to replicate the wall shear stresses (WSS) and wall shear forces (WSF) present in the anterior region of the nose. The WSS and …
Joint Determination Of Rack Configuration And Shelf Space Allocation To Maximize Retail Impulse Profit, Uttam Karki
Joint Determination Of Rack Configuration And Shelf Space Allocation To Maximize Retail Impulse Profit, Uttam Karki
Browse all Theses and Dissertations
For brick-and-mortar retailers to be successful, it is critical for them to optimally design their rack layout and place products in order to draw attention of shoppers. Literature suggests that racks placed at acute (or obtuse) angles to the main aisle frequented by shoppers can enhance visibility of products compared to racks placed orthogonally (i.e., 90˚). Placing products with high impulse purchase potential in the resulting highly visible locations on the rack can increase shopper impulse purchases. However, placing racks at angles other than 90˚ can increase the required floor space. Additionally, while reducing the height of the racks just …
Characterizing Basal-Like Triple Negative Breast Cancer Using Gene Expression Analysis: A Data Mining Approach, Qamar Alsabi
Characterizing Basal-Like Triple Negative Breast Cancer Using Gene Expression Analysis: A Data Mining Approach, Qamar Alsabi
Browse all Theses and Dissertations
Triple-negative breast cancer (TNBC) is characterized by the absence of expression of the estrogen receptor, progesterone receptor and human epidermal growth factor receptor 2 (HER2). Therefore, TNBC is unresponsive to targeted hormonal therapies, which limits treatment options to nonselective chemotherapeutic agents. Basal-like breast cancers (BLBCs) represent a subset of about 70% of TNBCs, more frequently affecting younger patients, being more prevalent in African-American women and significantly more aggressive than tumors of other molecular subtypes, with high rates of proliferation and extremely poor clinical outcomes. Proper classification of BLBCs using current pathological tools has been a major challenge. Although TNBCs have …
Monitoring Cerebral Functional Response Using Scmos-Based High Density Near Infrared Spectroscopic Imaging, Dharminder Singh Langri
Monitoring Cerebral Functional Response Using Scmos-Based High Density Near Infrared Spectroscopic Imaging, Dharminder Singh Langri
Browse all Theses and Dissertations
Neurovascular coupling is an important concept that indicates the direct link between neuronal electrical firing with the vascular hemodynamic changes. Functional Near Infrared Spectroscopy (fNIRS) can measure changes in cerebral vascular parameters of oxy-hemoglobin and deoxyhemoglobin concentrations and thus can provide neuronal activity through neurovascular coupling. Currently many commercial fNIRS devices are available, but they are limited by the number of channels (usually having only 8 detectors), which can limit the sensitivity, contrast, and resolution of imaging. High-density imaging can improve sensitivity, contrast, and resolution by providing many measurements and averaging the signals originating from the target cerebral focus area …
Assessing The Role Of Polyphenols As A Vascular Protectant Against Drug Induced Vascular Injury, Anson Jacob Oommen
Assessing The Role Of Polyphenols As A Vascular Protectant Against Drug Induced Vascular Injury, Anson Jacob Oommen
Browse all Theses and Dissertations
Vascular injury is identified during pre-clinical toxicity testing within certain pharmacological classes of drug candidates and induces degenerative and hyperplastic changes in endothelial (ECs) and vascular smooth muscle (VSMCs) cells. This drug-induced vascular injury has been show as a side-effect caused by various classes of drugs, including, antibacterial (e.g., azithromycin), anti-malarial (e.g., quinoline), anti-viral (e.g., anti-hepatitis C virus interferons) and nonsteroidal anti-inflammatory drugs (e.g., ibuprofen), and affects normal cardiovascular function and can further lead to various cardiovascular conditions like arrhythmia, cardiac arrest, high blood pressure, and even heart attack. The search for agents capable of reducing vascular injury side-effects by …
The Development Of The Human-Automation Behavioral Interaction Task (Habit) Analysis Framework, Isabelle Catherine Baird
The Development Of The Human-Automation Behavioral Interaction Task (Habit) Analysis Framework, Isabelle Catherine Baird
Browse all Theses and Dissertations
Complex systems involve the collaboration of automated agents and goal-oriented human operators in a dynamic environment, and dynamic environments required dynamic automation. The implementation of automation fundamentally changes the nature of the cognitive demands by means of changing the role of the human operator. The augmentation of operator situation awareness has become a major design objective in the development of human-automated systems. Extensive literature identified the out-of-the-loop performance problem as a human-automation interaction challenge. This thesis presents the Human-Automation Behavioral Interaction Task (HABIT) Analysis, as a novel approach to assessing human-automation interaction challenges, such as out-of-the-loop consequences. The novel framework …
Agent-Based Simulation Of Artificial-Intelligence-Assisted Transfer Of Care, Paul B. Stone
Agent-Based Simulation Of Artificial-Intelligence-Assisted Transfer Of Care, Paul B. Stone
Browse all Theses and Dissertations
This study demonstrates the application of Agent-Based Simulation as a potential training aid for Transfer of Care (ToC) between EMS and a hospital triage department. The specific aim was to develop a simulation to increase the efficiency and accountability of information communication during ToC to test the suitability of Agent-Based Simulation to address training requirements in complex, health provision settings. This paper focuses on the design of the training simulation, including the development of individual agents within the simulation through the user interface elements and the evaluation and verification of the prototype simulator. The primary objective is for the simulation …
Computational Simulation Of A Femoral Nail Fracture, Stephen Charles Whatley
Computational Simulation Of A Femoral Nail Fracture, Stephen Charles Whatley
Browse all Theses and Dissertations
Every year in the United States roughly 300,000 people over the age of 65 suffer from a hip fracture. Ninety five percent of which are the result from a fall. The resulting hip fracture can be classified into several categories of fracture. Depending on the damage the patient could be implanted with a femoral nail device to assist in their recovery. These devices can, however, have complications during recovery. In some cases, these nails can have a failure rate as high as 10%. When failure occurs, extensive investigations are needed to determine the causes of failure. These investigations involve physical …
A Model To Optimize Major Trauma Network Considering Patient Safety, Monit D. Vaishnav
A Model To Optimize Major Trauma Network Considering Patient Safety, Monit D. Vaishnav
Browse all Theses and Dissertations
Trauma is any physical injury that has the potential to cause prolonged disability and death if the appropriate level of care is not administered in a timely fashion. Existing approaches in the literature and by the American College of Surgeons (ACS) to optimize the network of trauma centers are limiting. To address this challenge, we introduce the Trauma Network Design Problem, a bi-objective mathematical model that aims at determining the optimal trauma network by minimizing the weighted sum of mistriages. We use the trauma network data from 2012 for the state of Ohio to illustrate the use of our approach …
Characterization Of In-Vivo Damage In Implantable Cardiac Devices And The Lead Residual Properties, Anmar Mahdi Salih
Characterization Of In-Vivo Damage In Implantable Cardiac Devices And The Lead Residual Properties, Anmar Mahdi Salih
Browse all Theses and Dissertations
Approximately, 92.1 million patients in the US suffer from cardiovascular diseases with an estimated healthcare cost of over $300 billion; out of which at least one million patients have Cardiac Implantable Electronics Devices (CIED). CIED represented by pacemakers, Implantable Cardioversion Defibrillator (ICD), and Cardiac Resynchronization Therapy (CRT) are exposed to in-vivo damage. These damages are complex and composed on multiple levels and present challenges while assessing their combined extent. Since 2004, more than one hundred recalls were reported for cardiac devices. ICD devices had the majority with 40.8% recalls, pacemaker recall percentage was 14.5%, CRT recall percentage was12.7%, leads recalls …