Engineering Commons^™

Population Fit Threshold: Fully Automated Signal Map Generation For Baseline Correction In Nmr-Based Metabolomics, Daniel C. Homer

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Baseline correction of NMR-based metabolomic spectra is a key step in data processing to elucidate biomarkers of diseased and toxic states. Automated baseline correction methods often use human-selected parameters. Presented is a method for automated baseline correction using parameters selected from and without manipulation of the spectrum. The focus is on generating an accurate signal map based on the differentiating characteristics of baseline noise and signal. The presented method of signal map generation and baseline correction was developed and tested on 13C and 1H NMR spectra. The spectra were as simple as chemical standards containing less than 25 signal peaks …

Radio Frequency Controlled Stimulation Of Intracellular Gold Or Silver Nanoparticle Conjugates For Use As Potential Sensors Or Modulators Of Biological Function, Richard Craig Murdock

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The objective of this investigation was to further explore the ability of a radio frequency (RF) signal to interact with metal nanoparticles (NPs) for the purposes of remote stimulation or control of cellular processes. Gold and silver NPs have shown the ability to be heated by electromagnetic frequencies, especially for the purpose of deactivating abnormal cells. However, the heating of the NPs in these previous studies was constant and uncontrolled. For this study, our hypothesis was by investigating the RF heating characteristics of NPs and its impact on surface functionalizations, a remotely stimulated control mechanism can be developed at the …

Use Of Web-Based Lessons Of Statistical Concepts With Graphics And Animation To Enhance The Effectiveness Of Learning, Lavanya Pillala

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Statistics is of critical importance to engineers. However, many engineering students struggle to grasp the meaning of statistical concepts and the idiosyncrasies of statistical methodologies. Because of this problem, instructors of statistics are constantly searching for better ways to help students understand statistical concepts. The goal of this project is to design and develop web-based lessons that use graphics and animations to enhance the effectiveness of students' learning of statistical concepts.

Lessons of three important statistical concepts have been developed for this thesis - normal distribution, central limit theorem and confidence & tolerance intervals - following well-recognized instructional design development …

Characterization And Improvement Of A Cone-Beam Ct Scanner For Quantitative Imaging, Jimish Dilip Joshi

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Computed tomography (CT) has various applications in different fields. In our case, the cone-beam CT scanner is used in the industrial field for qualitative and quantitative assessment of Procter and Gamble products. The Flash CT scanner, on which we do our research, has a microfocus x-ray tube, a detector size of 30 cm x 40 cm and a rotating stage for the object to be imaged. The x-ray tube can be operated up to 225 kV. Non-linearities in the response of the detector, scatter and beam hardening may cause false interpretations of the image values. To allow appropriate assessment of …

Domain-Specific Core Self-Evaluations And Stressors As Predictors Of Strains, Michael Raymond Hoepf

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The current study examines the use of a frame-of-reference (FOR) in the evaluation of core self-evaluations, stressors and strains. The study investigates the prediction that using a FOR that matches predictors and outcomes will result in a stronger relationship between the constructs being measured, specifically CSE, stressors, and strains. In addition, the study examines the extent to which following this procedure will add incremental validity after non-contextualized predictors are controlled. The hypotheses in this study were generally supported, although the hypotheses related to the school domain were not supported as strongly as those related to general and work domain. The …

An Improved Genetic Algorithm For Knapsack Problems, Taskiran, Gamze Kilincli

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In this study, an improved genetic algorithm (GA) is presented to solve the multidimensional 0-1 knapsack problem (MKP). The MKP is a well-known combinatorial optimization problem and has received wide attention from the operations research community for decades. Although recent advances in computing and optimization technologies have made the solution of small and medium size instances possible, this NP-hard problem, in general, still remains one of the challenging problems yet to be solved.

Of the various algorithms developed to solve the MKP, GA seems to be one of the best methods pointed out in the literature. A GA is an …

Finding Cadaveric Human Head Masses And Center Of Gravity: A Comparison Of Direct Measurement To 3d Ing, Grant Corwin Roush

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Mass properties of the human head are critical elements in developing neck injury threshold criteria in acceleration and impact environments. In order to accurately simulate the dynamics of the head in impact and acceleration environments, valid mass properties data for the human head must exist.

The purpose of this study was two-fold: First, to directly measure and generate a useful data set of human head mass properties and anthropometry, and second, compare the results from the direct measurement to measurements obtained using computed tomographic (CT) analyses of the human head. Four cadaveric human heads, all male, were measured.

For the …

Impact Of Culture And Age On The Use Of Social Networking Websites, Ramya Reddy Ponnavolu

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Social networking websites have become very popular amongst people of all ages in recent times. These websites have brought into existence a new form of data - 'User generated content'. Companies everywhere have begun to identify the potential of these sites and have commenced efforts to take advantage of the profitable opportunities available. In spite of all this, it is reasonable to say that the latent possibilities in social networking sites are yet to be fully explored. This is due to the fact that the technology is still young and research on its potential is still ongoing. The current research …

Computer-Based Skeletal Age Assessment Using Hand/Wrist Radiographs In Children 8-18 Years Old, Zhihong Ni

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Children's skeletons mature at different rates, and they can be affected by a variety of factors including disease, hormone imbalance or genetics. The assessment of skeletal maturity is a frequently performed procedure that allows the detection of hormonal, growth or genetic disorders. Several methods have been developed to estimate skeletal maturity. Most methods evaluate hand/wrist radiographs using indicators such as the ratios of various bone widths, the onset of the ossification of epiphysis and epiphyseal-diaphyseal fusion. Among those methods, the FELS method differs from others in the application of different grades to each indicator and the provision of a confidence …

A Biomechanical Comparison Of Locking Compression Plate Constructs With Plugs/Screws In Osteoporotic Bone Model, Krishna P. Desai

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Locking compression plates are proven to be safe for use in open reduction and internal fixation (ORIF) especially in osteoporotic bones. Because of various combinations of holes, the system provides more options for clinicians to use either locking screws or non-locking screws. This clinical research introduces screw like plugs which can be used along with the screws in case of locking compression plates. Experimental work was performed to determine the effectiveness of the plugs. The results showed that there is not a significant difference between the groups which used plugs and did not use the plugs, both in case of …