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Adaptive Identification Of Classification Decision Boundary Of Turbine Blade Mode Shape Under Geometric Uncertainty, Ian M. Boyd
Adaptive Identification Of Classification Decision Boundary Of Turbine Blade Mode Shape Under Geometric Uncertainty, Ian M. Boyd
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Integrally Bladed Rotors (IBR) of aircraft turbine engines suffer from fluctuations in the dynamic response that occurs due to blade to blade geometric deviations. The Stochastic Approach for Blade and Rotor Emulation (SABRE) framework has been used to enable a probabilistic study of mistuned blades in which a reduced order modeling technique is applied in conjunction with sets of surrogate models, called emulators, to make predictions of mistuned mode shapes. SABRE has proven useful for non-switching mode shapes. However, switching mode shapes have non-stationary or discontinuous response surfaces which reduce the accuracy of the surrogate models used in SABRE. To …
Scalable Clustering For Immune Repertoire Sequence Analysis, Prem Bhusal
Scalable Clustering For Immune Repertoire Sequence Analysis, Prem Bhusal
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The development of the next-generation sequencing technology has enabled systems immunology researchers to conduct detailed immune repertoire analysis at the molecule level. Large sequence datasets (e.g., millions of sequences) are being collected to comprehensively understand how the immune system of a patient evolves over different stages of disease development. A recent study has shown that the hierarchical clustering (HC) algorithm gives the best results for B-cell clones analysis - an important type of immune repertoire sequencing (IR-Seq) analysis. However, due to the inherent complexity, the classical hierarchical clustering algorithm does not scale well to large sequence datasets. Surprisingly, no algorithms …