Engineering Commons^™

Experimental And Computational Platforms For Studying Systems Mechanobiology, Brendyn Miller

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Mechanical stimulation through physical activity has been shown to play an important role in treating and preventing several non-communicable diseases such as hypertension, lower back pain (LBP), type-2 diabetes mellitus, and several cancers. This is accomplished through the regulation of cellular behavior and tissue remodeling within the body at both the micro- and macro-scale levels. The goal of mechanobiology research is to gain in-depth knowledge and understanding of how cells sense physical forces in conjunction with other biochemical cues and translate those factors into important biological functions that either maintain tissue homeostasis or lead to pathological states. Understanding these processes …

Ti-6al-4v Β Phase Selective Dissolution: In Vitro Mechanism And Prediction, Michael A Kurtz

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Retrieval studies document Ti-6Al-4V β phase dissolution within total hip replacement systems. A gap persists in our mechanistic understanding and existing standards fail to reproduce this damage. This thesis aims to (1) elucidate the Ti-6Al-4V selective dissolution mechanism as functions of solution chemistry, electrode potential and temperature; (2) investigate the effects of adverse electrochemical conditions on additively manufactured (AM) titanium alloys and (3) apply machine learning to predict the Ti-6Al-4V dissolution state. We hypothesized that (1) cathodic activation and inflammatory species (H₂O₂) would degrade the Ti-6Al-4V oxide, promoting dissolution; (2) AM Ti-6Al-4V selective dissolution would occur …

Investigation Of Fatigue Response With Analytical And Machine Learning Models And Hygroscopic Analysis Of Asymmetric Bistable Cfrp Composites, Shoab Ahmed Chowdhury

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Asymmetric bistable carbon fibre reinforced plastic (CFRP) composites enable a broad range of applications as they can sustain multiple stable configurations and have small snap-through load requirements. These unique features, coupled with their light strength-to-weight and stiffness-to-weight ratios, have made them preferred options for multifunctional systems. This study investigates the fatigue and hygroscopic response of 2-ply, [0/90] bistable CFRP laminates and proposes predictive modeling approaches for improved performance.

While previous studies widely researched and documented the fatigue of general composites in axial loading, fatigue analysis of asymmetric bistable composites in the out-of-plane snap-through direction is inadequate. This study performs fatigue …

Multiscale Topology Optimization With A Strong Dependence On Complementary Energy, Dustin Dean Bielecki

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A discrete approach introduces a novel deep learning approach for generating fine resolution structures that preserve all the information from the topology optimization (TO). The proposed approach utilizes neural networks (NNs) that map the desired engineering properties to seed for determining optimized structure. This framework relies on utilizing parameters such as density and nodal deflections to predict optimized topologies. A three-stage NN framework is employed for the discrete approach to reduce computational runtime while maintaining physics constraints.

A continuous representation that uses complementary energy (CE) methods to solve a representative element's homogenized properties consists of an embedded structure that is …

Algorithm Optimization And Hardware Acceleration For Machine Learning Applications On Low-Energy Systems, Jianchi Sun

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Machine learning (ML) has been extensively employed for strategy optimization, decision making, data classification, etc. While ML shows great triumph in its application field, the increasing complexity of the learning models introduces neoteric challenges to the ML system designs. On the one hand, the applications of ML on resource-restricted terminals, like mobile computing and IoT devices, are prevented by the high computational complexity and memory requirement. On the other hand, the massive parameter quantity for the modern ML models appends extra demands on the system's I/O speed and memory size. This dissertation investigates feasible solutions for those challenges with software-hardware …

A Novel Computationally Efficient Ai-Driven Generative Inverse Design Framework For Accelerating Topology Optimization And Designing Lattice-Infused Structures, Darshil Patel

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Multiscale topology optimization (TO) provides an inverse design computational framework for designing globally and locally optimized hierarchical structures. Triply periodic minimal surfaces (TPMS), a subclass of parametrically-driven lattice structures, exhibit unique properties such as large surface area, significant volume densities, and good strength-to-weight ratio, which makes them favorable for novel engineering applications. The recent advances in additive manufacturing and its ability to fabricate high-resolution structures have spurred interest in multiscale TO and TPMS for computationally designing finer and high-resolution designs. While multiscale TO and TPMS bring transformative opportunities in various applications, their potential for everyday use remains idle due to …