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Development Of Experimental Methods To Assess Adsorption Free Energy For Peptide-Surface Interactions, Yang Wei

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Because of its governing role in cellular response to implants and substrates for biomedical applications, the understanding and control of protein adsorption to material surfaces has been one of the major topics of research in the field of biomaterials. Unfortunately, it has proven to be extremely difficult to quantitatively understand and control these types of interactions because of the complexities involved, and existing methods that have been developed and used to characterize protein-surface interactions have proved to be inadequate to provide the level of detail necessary to achieve this understanding. New, more fundamental methods, both experimental and computational, are needed …