Engineering Commons^™

Application Of Electrostatic Dry Powder Coating Technology On Hard Capsules, Zhehao Jing

Electronic Thesis and Dissertation Repository

This project applied electrostatic dry powder coating technology on hard gelatin and HPMC capsules using Eudragit^® RS/RL and Eudragit^® L 100-55 to achieve sustained release and enteric release respectively. Dry powder coating eliminated the difficulties associated with conventional liquid coating processes such as poor adhesion and stickiness for capsules. Additionally, through optimizing sprayed plasticizer volume, the coating powders deposited on the capsules could be efficiently maximized. The weight gain of coating and the formulation of coating materials were important parameters which controlled the release profiles of coated capsules. The release mechanism of coated capsules was quite different from …

Apply Dry Powder On Drug Loading And Enteric Coating Of Esomeprazole Magnesium Trihydrate Beads And Capsules, Xiaojing Ge

Electronic Thesis and Dissertation Repository

Esomeprazole magnesium tri-hydrate (EMT) is a proton pump inhibitor, used for the treatment of gastric and duodenum ulcers. It is currently the best choice for the treatment of acid-related diseases, but it is extremely unstable in gastric acid and sensitive to wet, heat, light. It also will react with the enteric coating material used in this study. So enteric coating and sub coating is needed.

This study offers a new approach, dry powder coating technology, to achieve drug loading and enteric coating of EMT beads and capsules. Dry powder coating, a new type of solvent-less coating technology, can address most …