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Engineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Western University

2010

Action potential detection and classification

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A New Signal Processing Approach To Study Action Potential Content In Sympathetic Neural Signals, Aryan Salmanpour Nov 2010

A New Signal Processing Approach To Study Action Potential Content In Sympathetic Neural Signals, Aryan Salmanpour

Electronic Thesis and Dissertation Repository

Sympathetic nerve activity plays an essential role in the normal regulation of blood pressure in humans and in the etiology and progression of many chronic diseases. Sympathetic nerve recordings associated with blood pressure regulation can be recorded directly using microneurography. A general characteristic of this signal is spontaneous burst activity of spikes (action potentials) separated by silent periods against a background of considerable gaussian noise. During measurement with electrodes, the raw muscle sympathetic nerve activity (MSNA) signal is amplified, band-pass filtered, rectified and integrated. This integration process removes important information regarding action potential content and their discharge properties.

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