Engineering Commons^™

The Electrophysiology Of Resting State Fmri Networks, Carl David Hacker

McKelvey School of Engineering Theses & Dissertations

Traditional research in neuroscience has studied the topography of specific brain functions largely by presenting stimuli or imposing tasks and measuring evoked brain activity. This paradigm has dominated neuroscience for 50 years. Recently, investigations of brain activity in the resting state, most frequently using functional magnetic resonance imaging (fMRI), have revealed spontaneous correlations within widely distributed brain regions known as resting state networks (RSNs). Variability in RSNs across individuals has found to systematically relate to numerous diseases as well as differences in cognitive performance within specific domains. However, the relationship between spontaneous fMRI activity and the underlying neurophysiology is not …

On Control Systems Of The Brain: A Study Of Their Connections, Activations, And Interactions, Haoxin Sun

McKelvey School of Engineering Theses & Dissertations

Implementation of daily functions in humans crucially relies on both the bottom-up moment-to- moment processing of relevant input and output information as well as the top-down controls that instantiate and regulate goal-directed strategies. The current dissertation focuses on different systems of brain regions related to task control. We are interested in investigating, in detail, some of the basic activity patterns that different control systems carry during simple tasks, and how differences in activity patterns may shed new insight onto the distinctions among the systems' functional roles. In addition, carefully coordinated interactions between brain regions specialized for control-related activity and regions …

Fluorescence Imaging Of Cortical Calcium Dynamics: A Tool For Visualizing Mouse Brain Functions, Connections, And Networks, Patrick William Wright

McKelvey School of Engineering Theses & Dissertations

Hemodynamic-based markers of cortical activity (e.g. functional magnetic resonance imaging (fMRI) and optical intrinsic signal imaging) are an indirect and relatively slow report of neural activity driven by electrical and metabolic activity through neurovascular coupling, which presents significant limiting factors in deducing underlying brain network dynamics. As application of resting state functional connectivity (FC) measures is extended further into topics such as brain development, aging, and disease, the importance of understanding the fundamental basis for FC will grow.

In this dissertation, we extend functional analysis from hemodynamic- to calcium-based imaging. Transgenic mice expressing a fluorescent calcium indicator (GCaMP6) driven by …