Engineering Commons^™

Exploiting The Sars-Cov-2 Spike Protein Components To Guide Molecular Level Entry Of A Bag-1 Inhibitor In The Treatment Of Breast And Lung Cancers, Malak Yasin, Michael Peters, Mo Jiang

Summer REU Program

Chemoresistance of lung cancer cells is the primary reason as to why limitations occur with cancer treatments. A protein, known as BAG-1 is responsible for many cellular activities including cellular stress response, cell growth, and apoptosis (regulated cell death). When overexpressed, the protein has been linked to the anti-apoptotic behavior of cancer cells. BAG-1 can combine to heat shock proteins (HSPs), a family of helical molecular chaperones that are known to aid in the maturation of proteins, refolding, and degradation. This response plays a crucial role in the study of chemoresistance in cancer patients due to its detrimental nature. Prior, …

Design Of A Drug Delivery System Through The Gastrointestinal Tract, Kaixin Chen, Adel Husayni, Kayvon Mobarakeh, Ankit Soni

Capstone Design Expo Posters

Alzheimer’s Disease (AD) afflicts an estimated 5.3 million individuals and is the sixth leading cause of death in America. The drug delivery method of interest is an orally administered sustained-release delivery system that addresses the needs of the associated patient population. By augmenting drug delivery with a higher effective payload per dose compared to current methods, drug efficacy and bioavailability would improve. This will result in a decrease of the overall cost for medication as a greater percentage of the administered drug will be viable.

This design addresses the release of AD drug from the drug delivery system at the …