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Full-Text Articles in Engineering

Assisting End-Users In Creating Chatbots By Improving Training Data, Aparna Roy, Chris Egersdoerfer Jan 2022

Assisting End-Users In Creating Chatbots By Improving Training Data, Aparna Roy, Chris Egersdoerfer

Summer REU Program

No abstract provided.


Investigating Traction Forces Of Breast Cancer K14+ Leader Cells In Tumor Organoids, Ella Ramamurthy, Jessanne Lichtenberg, Priscilla Hwang Jan 2022

Investigating Traction Forces Of Breast Cancer K14+ Leader Cells In Tumor Organoids, Ella Ramamurthy, Jessanne Lichtenberg, Priscilla Hwang

Summer REU Program

No abstract provided.


Nlp@Vcu: Crop Characteristic Extraction Framework, Cora Lewis, Bridget Mcinnes, Getiria Onsongo Jan 2022

Nlp@Vcu: Crop Characteristic Extraction Framework, Cora Lewis, Bridget Mcinnes, Getiria Onsongo

Summer REU Program

We developed a crop characteristic extraction framework. Starting from a custom SpaCy named entity recognition model, we added pre-trained word embeddings and a part-of-speech based entity expansion post-processing step. Then, we implemented an evaluation framework that functioned as a 5-fold cross validation wrapper for SpaCy custom training. Preliminary results showed improvement in the extraction framework after these additions.


Evaluation Of Cell-Matrix Interactions In K14+ Leader Cells On Caf-Modulated Matrix, Trey P. Redman, Jessanne Y. Lichtenberg, Priscilla Y. Hwang Jan 2022

Evaluation Of Cell-Matrix Interactions In K14+ Leader Cells On Caf-Modulated Matrix, Trey P. Redman, Jessanne Y. Lichtenberg, Priscilla Y. Hwang

Summer REU Program

No abstract provided.


Exploiting The Sars-Cov-2 Spike Protein Components To Guide Molecular Level Entry Of A Bag-1 Inhibitor In The Treatment Of Breast And Lung Cancers, Malak Yasin, Michael Peters, Mo Jiang Jan 2022

Exploiting The Sars-Cov-2 Spike Protein Components To Guide Molecular Level Entry Of A Bag-1 Inhibitor In The Treatment Of Breast And Lung Cancers, Malak Yasin, Michael Peters, Mo Jiang

Summer REU Program

Chemoresistance of lung cancer cells is the primary reason as to why limitations occur with cancer treatments. A protein, known as BAG-1 is responsible for many cellular activities including cellular stress response, cell growth, and apoptosis (regulated cell death). When overexpressed, the protein has been linked to the anti-apoptotic behavior of cancer cells. BAG-1 can combine to heat shock proteins (HSPs), a family of helical molecular chaperones that are known to aid in the maturation of proteins, refolding, and degradation. This response plays a crucial role in the study of chemoresistance in cancer patients due to its detrimental nature. Prior, …


Optimization Of An Automated Algorithm For Analysis Of Spontaneous Rhythmic Bladder Contractions During Urodynamics Testing, Isabelle Pummill, Rui Li, Zachary Cullingsworth, Adam Klausner, John Speich Jan 2022

Optimization Of An Automated Algorithm For Analysis Of Spontaneous Rhythmic Bladder Contractions During Urodynamics Testing, Isabelle Pummill, Rui Li, Zachary Cullingsworth, Adam Klausner, John Speich

Summer REU Program

No abstract provided.


A Highly Conductive, Flexible, And 3d-Printable Carbon Nanotube-Elastomer Ink For Additive Bio-Manufacturing, Andy Shar, Phillip Glass, Daeha Joung Ph.D. Jan 2022

A Highly Conductive, Flexible, And 3d-Printable Carbon Nanotube-Elastomer Ink For Additive Bio-Manufacturing, Andy Shar, Phillip Glass, Daeha Joung Ph.D.

Undergraduate Research Posters

The synthesis of a highly conductive, flexible, 3D-printable, and biocompatible ink has been of great interest in the field of bio-based additive manufacturing. Various applications include ultra-sensitive, microscale tactile sensors, patient-customizable scaffolds for cardiac and nerve tissue regeneration, and flexible electrocardiogram (ECG) electrodes. Here, a novel elastomeric carbon nanocomposite is presented consisting of amino-functionalized carbon nanotubes (CNT-NH2) homogenously dispersed in a one-part room-temperature vulcanizing (RTV) silicone matrix. The use of acetone as a swelling solvent aids in electrical percolation through the elastomer matrix. CNT-NH2 ratios can be tuned to fit various needs; higher tensile strength is favored …


Exploring Cell Differentiation Vs. Localization In Engineered Ligament-To-Bone Entheses, Saagar N. Sheth, Michael E. Brown, Jennifer L. Puetzer Jan 2022

Exploring Cell Differentiation Vs. Localization In Engineered Ligament-To-Bone Entheses, Saagar N. Sheth, Michael E. Brown, Jennifer L. Puetzer

Undergraduate Research Posters

The anterior cruciate ligament (ACL) connects to bone via structurally complex insertions known as entheses that translate load from elastic ligament and stiff bone via gradients in organization, composition, and cell phenotype [1]. These gradients are not recreated in graft repair or engineered replacements, yielding limited repair options and high failure rates [2]. Previously, we developed a culture system that uses a tensile-compressive interface to guide ligament fibroblasts to develop early postnatal-like entheses by 6 weeks [3]; however, cells used were isolated from the entirety of the neonatal bovine ACL from bone to bone and likely contained multiple cell phenotypes …