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Amorphous Silica Based Biomaterials For Musculoskeletal Tissue Regeneration Applications, Kamal Awad

Material Science and Engineering Dissertations

Musculoskeletal (MSK) injury includes any injuries that affect the bones, muscles, ligaments, tendons, or nerves. Open bone fracture is one of the common types of MSK traumatic injuries which results in not only bone fracture but also damage/loss of associated muscles, nerve, vasculature, endothelium, periosteum, fascia, and connective tissue. Surgical procedures and biological interventions are required to fix the broken bone, and muscle transfer is performed to compensate the skeletal muscle defects. Current treatments include fixative metal implants and regenerative biopolymer scaffolds, then muscle flap procedures to cover the bone. Yet, these treatments are inadequate because the used materials do …