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Full-Text Articles in Engineering
Alpha Synuclein: A Therapeutic Target And Biomarker For Parkinson’S Disease, Max Chase
Alpha Synuclein: A Therapeutic Target And Biomarker For Parkinson’S Disease, Max Chase
USF Tampa Graduate Theses and Dissertations
Parkinson’s Disease is the second most common neurodegenerative disease after Alzheimer’s Disease, and the most common motor disorder. In fact, nearly a third of those with AD have PD. A major hallmark of PD is the appearance of Lewy Bodies, proteinaceous cytoplasm inclusions, that build up and spread throughout the CNS in a prion like fashion. The major component of these Lewy Bodies is a protein called alpha-synuclein. Alpha-syn is a 14kDa protein made of 140 amino acids and found in the presynaptic ends of CNS neurons, acting as a chaperone and regulator. The protein is also found in the …
Detecting Symptoms Of Chronic Obstructive Pulmonary Disease And Congestive Heart Failure Via Cough And Wheezing Sounds Using Smart-Phones And Machine Learning, Anthony Windmon
USF Tampa Graduate Theses and Dissertations
Chronic Obstructive Pulmonary Disease (COPD) and Congestive Heart Failure (CHF) are progressive disorders, and major health concerns among today’s aging population. COPD causes a large mucus buildup in the lungs, leading to chronic cough and difficulty to breathe. CHF causes fluid buildup in the lower lungs due to the failing heart, causing cough and difficulty to breath. People who are clinically diagnosed with COPD or CHF are expected to regularly monitor their symptoms and follow complex medical recommendations in an effort to prevent exacerbation. In this dissertation, we elaborate upon three different machine learning based techniques that we developed for …