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Full-Text Articles in Engineering
Comparative Analysis Of Computationally Accelerated Ngs Alignment, Ada Chaeli Van Der Zijp-Tan
Comparative Analysis Of Computationally Accelerated Ngs Alignment, Ada Chaeli Van Der Zijp-Tan
Honors Theses
The Smith-Waterman algorithm is the basis of most current sequence alignment technology, which can be used to identify similarities between sequences for cancer detection and treatment because it provides researchers with potential targets for early diagnosis and personalized treatment. The growing number of DNA and RNA sequences available to analyze necessitates faster alignment processes than are possible with current iterations of the Smith-Waterman (S-W) algorithm. This project aimed to identify the most effective and efficient methods for accelerating the S-W algorithm by investigating recent advances in sequence alignment. Out of a total of 22 articles considered in this project, 17 …
Determination Of Pollutant Load Reductions To Three Mile Creek As A Result Of The Implementation Of Storm Water Bio-Infiltration Basins On The Usa Campus, Jordan E. Blackmon
Determination Of Pollutant Load Reductions To Three Mile Creek As A Result Of The Implementation Of Storm Water Bio-Infiltration Basins On The Usa Campus, Jordan E. Blackmon
Honors Theses
Three Mile Creek has been identified as an impaired urban stream and is now a priority for cleanup for both the City of Mobile and the Alabama Department of Environmental Management. Methods to better manage storm water runoff on the USA campus have begun, with a goal to reduce sediment and nutrient inputs to Three Mile Creek. Both sediment and nutrient inputs to Three Mile Creek disrupt habitat and lower dissolved oxygen concentrations, which are detrimental to overall stream health. Low Impact Development strategies are an innovative way to use nature-like, green-infrastructures to minimize storm water runoff quantity and improve …
Amplification And Filtering Stage For An In-Home Wireless Polysomnograph, Seth Young
Amplification And Filtering Stage For An In-Home Wireless Polysomnograph, Seth Young
Honors Theses
Obstructive sleep apnea is a sleep disorder that tends to be easily treatable but, for most sufferers, is undiagnosed. To lower the economic barriers to screening the design of a portion of a polysomnograph, or obstructive sleep apnea testing tool, is considered. A filtering and amplification stage is theorized, simulated, and constructed for testing. The stage, consisting of three cascaded 1st order Butterworth low pass filters and amplifiers, did not achieve the target signal to noise ratio for a sinusoidal waveform of amplitude 200µv, but showed promising signal to noise ratios for waveforms with amplitudes as low as 600µv. The …
Understanding The Behavior Of Ionic Liquids In Poly (Methyl Methacrylate) Through Molecular Dynamics, Alejandro Gallegos Tovar
Understanding The Behavior Of Ionic Liquids In Poly (Methyl Methacrylate) Through Molecular Dynamics, Alejandro Gallegos Tovar
Honors Theses
Ionogels are polymer networks swollen by ionic liquids (ILs). They are used for electrochemical devices (lithium-ion batteries, thin-film transistors, and fuel cells) and as permeation membranes for gas separation. The interactions and phase behaviors of an ionic liquid (IL) in a polymer are the most important factor when building ionogels. The molecular behavior between poly(methyl methacrylate) (PMMA) and 1-butyl-3- methylimidazolium with four different anionic structures has been studied. The behavior between ILs and polymers is governed by a complex mix of factors such as polymer concentration, polymer and IL hydrophobicity, inter and intramolecular forces, and temperature. Molecular simulations of different …
Ogt Glycosylation Of Histones In T Cells May Participate In Systemic Lupus Erythematosus, Jared Luke Ridgeway
Ogt Glycosylation Of Histones In T Cells May Participate In Systemic Lupus Erythematosus, Jared Luke Ridgeway
Honors Theses
Systemic Lupus Erythematosus (SLE) is a chronic autoimmune disease that primarily affects women. The etiology is not known yet, but genetics and environmental factors trigger the disease. These epigenetic changes modify gene expression and contribute to the development of the disease. It is known that T cells from patients with lupus overexpress genes that may contribute to the onset and progression of the disease. Dr. Gorelik has shown that OGT (O-linked N-acetyl-Glucosamine Transferase), which is an X-linked gene, is overexpressed in women with SLE. OGT adds b-N-acetylglucosamine (O-GlcNAc) to serine and threonine residues of proteins. …
Gq-Mediated Ca** Signals In Human Airway Smooth Muscle Cells, Hanna Viktoria Bobinger
Gq-Mediated Ca** Signals In Human Airway Smooth Muscle Cells, Hanna Viktoria Bobinger
Honors Theses
Current asthma therapies include corticosteroids, long acting β2-adrenergic receptor (β2-AR) agonists paired with corticosteroids, or short-acting β2-AR agonists used in rescue inhalers. Chronic use of β-agonists results in diminished effectiveness, and use of long-acting β-agonists can even exacerbate asthma symptoms; this is partly because anti-inflammatory therapy does not directly address the exaggerated airway narrowing due to excessive shortening of airway smooth muscle (ASM), which is the hallmark of asthma. These observations led our collaborators to investigate other potential asthma therapies – bitter taste agonists. 2 Bitter taste agonists, such as chloroquine, activate a subset of Gq-coupled receptors known as bitter …
Thermal And Thermophysical Properties Of Anionic Amines And Their Aqueous Solutions For Co2 Capture In Confined Environments, Randi Swanson
Thermal And Thermophysical Properties Of Anionic Amines And Their Aqueous Solutions For Co2 Capture In Confined Environments, Randi Swanson
Honors Theses
Air revitalization for the International Space Station (ISS) has been identified by NASA as a mission critical need which requires improvement. The current method uses13X zeolite, a solid adsorbent, to adsorb carbon dioxide. While this is effective, the zeolite adsorbent produces dust that is unwelcome on the space station. Furthermore, the adsorbentis too sensitive to humidity in moderate temperature gas streams [1]. Aqueous solutions of ionic amines show promise as a safe and efficient solution, as they do not volatilize and are not water sensitive [2]. Specifically, anionic amines have the most potential because of the amine functional group’s ability …