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Full-Text Articles in Engineering
Metallic And Ceramic Thin Film Thermocouples For Gas Turbine Engines, Ian M. Tougas, Martin Amani, Otto J. Gregory
Metallic And Ceramic Thin Film Thermocouples For Gas Turbine Engines, Ian M. Tougas, Martin Amani, Otto J. Gregory
Chemical Engineering Faculty Publications
Temperatures of hot section components in today’s gas turbine engines reach as high as 1,500 °C, making in situ monitoring of the severe temperature gradients within the engine rather difficult. Therefore, there is a need to develop instrumentation (i.e., thermocouples and strain gauges) for these turbine engines that can survive these harsh environments. Refractory metal and ceramic thin film thermocouples are well suited for this task since they have excellent chemical and electrical stability at high temperatures in oxidizing atmospheres, they are compatible with thermal barrier coatings commonly employed in today’s engines, they have greater sensitivity than conventional …
Characterization And Aerosol Dispersion Performance Of Spray-Dried Chemotherapeutic Pegylated Phospholipid Particles For Dry Powder Inhalation Delivery In Lung Cancer, Samantha A. Meenach, Kimberly W. Anderson, J. Zach Hilt, Ronald J. Mcgarry, Heidi M. Mansour
Characterization And Aerosol Dispersion Performance Of Spray-Dried Chemotherapeutic Pegylated Phospholipid Particles For Dry Powder Inhalation Delivery In Lung Cancer, Samantha A. Meenach, Kimberly W. Anderson, J. Zach Hilt, Ronald J. Mcgarry, Heidi M. Mansour
Chemical Engineering Faculty Publications
Pulmonary inhalation chemotherapeutic drug delivery offers many advantages for lung cancer patients in comparison to conventional systemic chemotherapy. Inhalable particles are advantageous in their ability to deliver drug deep in the lung by utilizing optimally sized particles and higher local drug dose delivery. In this work, spray-dried and co-spray dried inhalable lung surfactant-mimic PEGylated lipopolymers as microparticulate/nanoparticulate dry powders containing paclitaxel were rationally designed via organic solution advanced spray drying (no water) in closed-mode from dilute concentration feed solution. Dipalmitoylphosphatidylcholine (DPPC) and dipalmitoylphosphatidylethanolamine poly(ethylene glycol) (DPPE-PEG) with varying PEG chain length were mixed with varying amounts of paclitaxel in methanol …