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Articles 1 - 2 of 2
Full-Text Articles in Engineering
Scalable, Biofunctional, Ultra-Stable Nano- Bio- Composite Materials Containing Living Cells, Patrick E. Johnson, C. Jeffrey Brinker, Graham Timmins, Jacob Agola, Jason Harper
Scalable, Biofunctional, Ultra-Stable Nano- Bio- Composite Materials Containing Living Cells, Patrick E. Johnson, C. Jeffrey Brinker, Graham Timmins, Jacob Agola, Jason Harper
Nanoscience and Microsystems ETDs
Three-dimensional encapsulation of cells within nanostructured silica gels or matrices enables applications as diverse as biosensors, microbial fuel cells, artificial organs, and vaccines. It also allows study of individual cell behaviors. Recent progress has improved the performance and flexibility of cellular encapsulation, yet there remains a need for robust scalable processes for large format production of cell-encapsulating materials. Here, we detail two novel techniques, that enable the large-scale production of functional Nano-Bio-Composites (NBCs) containing living cells within ordered 3-D lipid/silica nanostructures: 1) thick-casting and 2) spray drying. Furthermore, we detail a third technique for material scaling in which aqueous, silicate-based …
Developing Droplet Based 3d Cell Culture Methods To Enable Investigations Of The Chemical Tumor Microenvironment, Jacqueline A. De Lora
Developing Droplet Based 3d Cell Culture Methods To Enable Investigations Of The Chemical Tumor Microenvironment, Jacqueline A. De Lora
Biomedical Sciences ETDs
Adaptation of cancer cells to changes in the biochemical microenvironment in an expanding tumor mass is a crucial aspect of malignant progression, tumor metabolism, and drug efficacy. In vitro, it is challenging to mimic the evolution of biochemical gradients and the cellular heterogeneity that characterizes cancer tissues found in vivo. It is well accepted that more realistic and controllable in vitro 3D model systems are required to improve the overall cancer research paradigm and thus improve on the translation of results, but multidisciplinary approaches are needed for these advances. This work develops such approaches and demonstrates that new droplet-based cell-encapsulation …