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Full-Text Articles in Engineering
Optical Probing Of Gastrocnemius In Patients With Peripheral Artery Disease Characterizes Myopathic Biochemical Alterations And Correlates With Stage Of Disease, Ryan A. Becker, Kim Cluff, Nithyanandhi Duraisamy, Hootan Mehraein, Hussam Farhoud, Tracie Collins, George P. Casale, Iraklis I. Pipinos, Jeyamkondan Subbiah
Optical Probing Of Gastrocnemius In Patients With Peripheral Artery Disease Characterizes Myopathic Biochemical Alterations And Correlates With Stage Of Disease, Ryan A. Becker, Kim Cluff, Nithyanandhi Duraisamy, Hootan Mehraein, Hussam Farhoud, Tracie Collins, George P. Casale, Iraklis I. Pipinos, Jeyamkondan Subbiah
Department of Biological Systems Engineering: Papers and Publications
Peripheral artery disease (PAD) is a condition caused by atherosclerotic blockages in the arteries supplying the lower limbs and is characterized by ischemia of the leg, progressive myopathy, and increased risk of limb loss. The affected leg muscles undergo significant changes of their biochemistry and metabolism including variations in the levels of many key proteins, lipids, and nucleotides. The mechanisms behind these changes are poorly understood. The objective of this study was to correlate the severity of the PAD disease stage and associated hemodynamic limitation (determined by the ankle brachial index, ABI) in the legs of the patients with alterations …
Disturbed Cyclical Stretch Of Endothelial Cells Promotes Nuclear Expression Of The Pro-Atherogenic Transcription Factor Nf-Kb, Ryan M. Pedrigi, Konstantinos I. Papadimitriou, Avinash Kondiboyina, Sukhjinder Sidhu, James Chau, Miten B. Patel, Daniel C. Baeriswyl, Emmanuel M. Drakakis, Rob Krams
Disturbed Cyclical Stretch Of Endothelial Cells Promotes Nuclear Expression Of The Pro-Atherogenic Transcription Factor Nf-Kb, Ryan M. Pedrigi, Konstantinos I. Papadimitriou, Avinash Kondiboyina, Sukhjinder Sidhu, James Chau, Miten B. Patel, Daniel C. Baeriswyl, Emmanuel M. Drakakis, Rob Krams
Department of Mechanical and Materials Engineering: Faculty Publications
Exposure of endothelial cells to low and multidirectional blood flow is known to promote a pro-atherogenic phenotype. The mechanics of the vessel wall is another important mechano-stimulus within the endothelial cell environment, but no study has examined whether changes in the magnitude and direction of cell stretch can be pro-atherogenic. Herein, we developed a custom cell stretching device to replicate the in vivo stretch environment of the endothelial cell and examined whether low and multidirectional stretch promote nuclear translocation of NF-kB. A fluid–structure interaction model of the device demonstrated a nearly uniform strain within the region of cell attachment and …