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University of Nebraska - Lincoln
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
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Stretch Control Of Adipocyte Insulin Signaling, Tasneem Bouzid
Stretch Control Of Adipocyte Insulin Signaling, Tasneem Bouzid
Department of Mechanical and Materials Engineering: Dissertations, Theses, and Student Research
Obesity and related metabolic disorders have reached global epidemic proportions in recent decades. Excess and hypertrophic adipose tissue has been implicated in the development of various pathological diseases and disorders including Type-2 diabetes mellitus (Type-2 DM). In addition to serving as energy storage for the body, evidence also suggests that adipose tissue behaves as an endocrine organ capable of secreting bioactive cytokines known as adipokines, which mediate insulin signaling pathways in various tissues. Physical exercise has been demonstrated to positively affect insulin signaling activities potentially through increasing the secretion of insulin sensitizing adipokines and/or decreasing the secretion of pro-inflammatory insulin …