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Full-Text Articles in Engineering
Cavitation Rheology For Soft Materials, Jessica A. Zimberlin, Naomi Sanabria-Delong, Gregory N. Tewmassachusetts - Amherst, Alfred J. Crosby
Cavitation Rheology For Soft Materials, Jessica A. Zimberlin, Naomi Sanabria-Delong, Gregory N. Tewmassachusetts - Amherst, Alfred J. Crosby
Gregory N. Tew
To guide the development of tissue scaffolds and the characterization of naturally heterogeneous biological tissues, we have developed a method to determine the local modulus at an arbitrary point within a soft material. The method involves growing a cavity at the tip of a syringe needle and monitoring the pressure of the cavity at the onset of a mechanical instability. This critical pressure is directly related to the local modulus of the material. The results focus on the network development of poly(lactide)–poly(ethylene oxide)–poly(lactide) triblock copolymer and poly(vinyl alcohol) hydrogels. These materials serve as model materials for tissue scaffolds and soft …
Activity Of An Antimicrobial Peptide Mimetic Against Planktonic And Biofilm Cultures Of Oral Pathogens, Nicholas Beckloff, Danielle Laube, Tammy Castro, David Furgang, Steven Park, David Perlin, Dylan Clements, Haizhong Tang, Richard W. Scott, Gregory N. Tew, Gill Diamond
Activity Of An Antimicrobial Peptide Mimetic Against Planktonic And Biofilm Cultures Of Oral Pathogens, Nicholas Beckloff, Danielle Laube, Tammy Castro, David Furgang, Steven Park, David Perlin, Dylan Clements, Haizhong Tang, Richard W. Scott, Gregory N. Tew, Gill Diamond
Gregory N. Tew
Antimicrobial peptides (AMPs) are naturally occurring, broad-spectrum antimicrobial agents that have recently been examined for their utility as therapeutic antibiotics. Unfortunately, they are expensive to produce and are often sensitive to protease digestion. To address this problem, we have examined the activity of a peptide mimetic whose design was based on the structure of magainin, exhibiting its amphiphilic structure. We demonstrate that this compound, meta-phenylene ethynylene (mPE), exhibits antimicrobial activity at nanomolar concentrations against a variety of bacterial and Candida species found in oral infections. Since Streptococcus mutans, an etiological agent of dental caries, colonizes the tooth surface and forms …