Engineering Commons^™

Reactive Chemistries For Protein Labeling, Degradation, And Stimuli Responsive Delivery, Myrat Kurbanov

Doctoral Dissertations

Reactive chemistries for protein chemical modification play an instrumental role in chemical biology, proteomics, and therapeutics. Depending on the application, the selectivity of these modifications can range from precise modification of an amino acid sequence by genetic manipulation of protein expression machinery to a stochastic modification of lysine residues on the protein surface. Ligand-Directed (LD) chemistry is one of the few methods for targeted modification of endogenous proteins without genetic engineering. However, current LD strategies are limited by stringent amino acid selectivity. To bridge this gap, this thesis focuses on the development of highly reactive LD Triggerable Michael Acceptors (LD-TMAcs) …

Steel Deck Diaphragms: Characterizing The Hysteretic Behavior Of Light Gage Steel, Screw-Fastened, Support And Sidelap Connections And The Influence Of Support Connections On The Stability Behavior Of Panels, Divyansh Kapoor

Doctoral Dissertations

Steel deck diaphragms are planar structures that serve as critical components of a metal building’s lateral force-resisting system. These can be found in walls, floors, and roofs of metal buildings and aid with the lateral stability of the structure. The diaphragm design process involves the selection of materials, deck geometry, connections, and connection detailing across the steel panels. The American Iron and Steel Institute’s AISI S310 and Steel Deck Institutes DDM04 both provide design guidance on the selection and detailing of materials and fasteners for the applicable limit states of connections and stability of the panels. Both design codes provide …

Mobile Intelligent Agents: Interplay Of Communications, Privacy, And Decision Making, Saeede Enayati

Doctoral Dissertations

The development of processors and sensor technologies and the advent of artificial intelligence (AI) have led to the growth of more capable and affordable mobile intelligent agents like unmanned aerial vehicles (UAVs) which have numerous applications in areas such as construction, search and rescue operations, oil and gas, agriculture, etc. The use of AI and machine learning (ML) algorithms in UAVs has enabled real-time data-driven decision-making frameworks but poses numerous challenges including high-impact decision-making, security, energy management, communication, and automation, to name a few. In this dissertation, we propose solutions to some of these problems. First, we give our attention …

Experimental Investigation Of The Vortex-Induced Vibration Response Of A Flexibly-Mounted Rigid Cylinder In The Shear-Thinning And Inertial-Viscoelastic Flow Regimes, Pieter Boersma

Doctoral Dissertations

Flexible or flexibly-mounted structures with bluff cross-sections in flow can shed vortices at frequencies that increase with increasing flow velocity. When this shedding frequency is equal to the structure's natural frequency, the structure can oscillate. This is called vortex-induced vibrations (VIV). VIV is present in multiple fluid-structure interaction (FSI) systems which can be found in industrial, medical, and engineering applications. These oscillations can be desirable or undesirable, so understanding the physics behind this phenomenon is important. This work seeks to investigate experimentally the VIV response in the inertial-viscoelastic regime where fluid inertia and elasticity influence the system. The subcritical Newtonian …

Optimizing Channel Formation In Peg Maleimide Hydrogels, Bakthavachalam Kannadasan

Masters Theses

Blood vessels including the arteries, veins, and capillaries are a critical and indispensable component of various organisms. Some studies estimate that if all the blood vessels present in our body are arranged in line, they would amount to a total length of approximately 60,000 miles. This distance is enough to circle the world two and a half times! In addition to being all pervasive, blood vessels perform certain key functions such as delivery of oxygen and nutrients to various tissues in the body. They also assist in the spread of diseases such as cancer. Therefore, it is important to study …

Electrostatic Effects On Lipid Bilayer Physicochemal Properties And Vesicle Adhesion, Oscar Zabala-Ferrera

Doctoral Dissertations

Lipids are an integral part of cells, being the principal component of the cell membrane, and contributing to the function and regulation of biological processes. Lipid nanoparticles mimicking a cell’s endosomes or exosomes are of particular interest within the pharmaceutical industry for their ability to deliver cargo such as RNA into target cells. The delivery process faces a multitude of challenges, so a rational design approach for vesicles that considers a lipid’s physicochemical contribution to the membrane is desired. To that end, this thesis explores the creation of large area biomembranes along with the development of electromechanical and optical characterization …

Resource Allocation In Subsidy Welfare Programs: Managerial Insights For Nonprofits, Governments, And Service Providers, Wei Wei

Doctoral Dissertations

Subsidy welfare programs provide financial assistance to economically disadvantaged individuals and families to access essential and life-altering services (e.g., education, child care, and housing) that they might not otherwise have access to. Access to these services is considered critical to achieving a better and more sustainable future for all. As such, these high-quality services are directly related to several United Nations Sustainable Development Goals, which were adopted as a universal call to action to end poverty, save the planet and improve the lives and prospects of everyone, everywhere." In particular, the need for these affordable and high-quality services has been …

Machine Learning Modeling Of Polymer Coating Formulations: Benchmark Of Feature Representation Schemes, Nelson I. Evbarunegbe

Masters Theses

Polymer coatings offer a wide range of benefits across various industries, playing a crucial role in product protection and extension of shelf life. However, formulating them can be a non-trivial task given the multitude of variables and factors involved in the production process, rendering it a complex, high-dimensional problem. To tackle this problem, machine learning (ML) has emerged as a promising tool, showing considerable potential in enhancing various polymer and chemistry-based applications, particularly those dealing with high dimensional complexities.

Our research aims to develop a physics-guided ML approach to facilitate the formulations of polymer coatings. As the first step, this …

Analog Cancellation Of A Known Remote Interference: Hardware Realization And Analysis, James M. Doty

Masters Theses

The onset of quantum computing threatens commonly used schemes for information secrecy across wireless communication channels, particularly key-based data-level encryption. This calls for secrecy schemes that can provide everlasting secrecy resistant to increased computational power of an adversary. One novel physical layer scheme proposes that an intended receiver capable of performing analog cancellation of a known key-based interference would hold a significant advantage in recovering small underlying messages versus an eavesdropper performing cancellation after analog-to-digital conversion. This advantage holds even in the event that an eavesdropper can recover and use the original key in their digital cancellation. Inspired by this …

Refinement And Performance Analysis Of The Stepped Frequency Microwave Radiometer In Extra Tropical Cyclone Conditions, Jezabel Vilardell Sanchez

Doctoral Dissertations

The Stepped Frequency Microwave Radiometer (SFMR) is a key instrument for estimation of ocean surface wind speed and rain rate in tropical and extra-tropical cyclones research. Through the observed brightness temperature (TB) over a range of six C-band frequencies, the SFMR derives these key parameters used by hurricane specialists to issue watches and warnings. The information gathered with this instru- ment is also pivotal for post-storm studies and satellite calibrations. Currently, the SFMR requires an average time of 5-10 seconds of averaging to cycle through the six di↵erent frequency channels, so in regions with strong wind/rain gradients such as the …

Thermal Conductivity And Mechanical Properties Of Interlayer-Bonded Graphene Bilayers, Afnan Mostafa

Masters Theses

Graphene, an allotrope of carbon, has demonstrated exceptional mechanical, thermal, electronic, and optical properties. Complementary to such innate properties, structural modification through chemical functionalization or defect engineering can significantly enhance the properties and functionality of graphene and its derivatives. Hence, understanding structure-property relationships in graphene-based metamaterials has garnered much attention in recent years. In this thesis, we present molecular dynamics studies aimed at elucidating structure-property relationships that govern the thermomechanical response of interlayer-bonded graphene bilayers.

First, we present a systematic and thorough analysis of thermal transport in interlayer-bonded twisted bilayer graphene (IB-TBG). We find that the introduction of interlayer C-C …

Mining High Impact Combinations Of Conditions From The Medical Expenditure Panel Survey, Arjun Mohan

Masters Theses

The condition of multimorbidity — the presence of two or more medical conditions in an individual — is a growing phenomenon worldwide. In the United States, multimorbid patients represent more than a third of the population and the trend is steadily increasing in an already aging population. There is thus a pressing need to understand the patterns in which multimorbidity occurs, and to better understand the nature of the care that is required to be provided to such patients.

In this thesis, we use data from the Medical Expenditure Panel Survey (MEPS) from the years 2011 to 2015 to identify …

Micro And Nano R2r Embossing Of Extruded Polymers, Raymond S. Frenkel

Doctoral Dissertations

This dissertation presents a process for directly imprinting or embossing extruded polymers as an advancement in roll-to-roll (R2R) embossing methods that avoids the problems of converting preformed films, increases throughput, and reduces costs. A proof-of-concept R2R apparatus was designed and constructed for directly embossing extruded polymer, and experimental results were evaluated. This laboratory scale R2R apparatus employed a thin metal ribbon belt mold with micro or nano scale features in a calendering setup, with a close coupled induction heating (IH) coil to preheat the ribbon mold above glass transition temperature (T_g) of the polymer, prior to contact with …

Fingerprinting For Chiplet Architectures Using Power Distribution Network Transients, Matthew G. Burke

Masters Theses

Chiplets have become an increasingly popular technology for extending Moore's Law and improving the reliability of integrated circuits. They do this by placing several small, interacting chips on an interposer rather than the traditional, single chip used for a device. Like any other type of integrated circuit, chiplets are in need of a physical layer of security to defend against hardware Trojans, counterfeiting, probing, and other methods of tampering and physical attacks.

Power distribution networks are ubiquitous across chiplet and monolithic ICs, and are essential to the function of the device. Thus, we propose a method of fingerprinting transient signals …

The Current State Of Practice Of Building Information Modeling, Kevin P. Brooks

Masters Theses

Building Information Modeling (BIM) has become extremely prominent in the construction industry in the past twenty years. It serves as a digital repository that can, when used to its fullest potential, combine all aspects of designing, building, and managing a structure in one place, alongside all the data produced in those processes. The construction industry has to date struggled to increase productivity alongside similar fields, such as the manufacturing industry, though the construction industry generally has far more stakeholders on one project than the manufacturing industry. Further, building designs are becoming more complex while project schedules are becoming tighter. As …

Design And Fabrication Of A Trapped Ion Quantum Computing Testbed, Christopher A. Caron

Masters Theses

Here we present the design, assembly and successful ion trapping of a room-temperature ion trap system with a custom designed and fabricated surface electrode ion trap, which allows for rapid prototyping of novel trap designs such that new chips can be installed and reach UHV in under 2 days. The system has demonstrated success at trapping and maintaining both single ions and cold crystals of ions. We achieve this by fabricating our own custom surface Paul traps in the UMass Amherst cleanroom facilities, which are then argon ion milled, diced, mounted and wire bonded to an interposer which is placed …

Improving Energy Efficiency Of School Buildings With Solar-Assisted Cooling For The Maldives, Ahmed Fathhee

Masters Theses

Anthropogenic activities are responsible for the impact of global climate change because of burning fossil fuels releasing harmful gases into the environment. As a result, the global temperature has risen about 1.18 °C since 1880, causing the global sea level to rise by 178 mm over the past century. This is a threat to countries that are closer to the ocean, especially the low-lying countries such as the Maldives. It is predicted if the sea level keeps rising, most of these islands could be below sea level by 2030.

The Maldives has a tropical climate requiring cooling to achieve thermal …

The Effects Of Hurricane Wind Field Characteristics On Wind Blade Loads, Michael S. Tsai

Masters Theses

Over recent years, offshore wind energy has been growing around the world. This necessitates placing wind turbines directly in or near the oceans where hurricanes can be. Previous research has suggested that hurricane wind veer and direction change can have adverse loading effects on the turbine. Such effects can create damage to the blade or worsen existing ones. Currently, there is no known design standard for addressing wind veer and direction change specifically from hurricanes. Quantifying the loading contribution from these phenomena is not abundant either.

This thesis seeks to demonstrate a proposed procedure for defining design veer profiles and …

Post-Fire Damage Inspection Of Concrete Tunnel Structures, James Viglas

Masters Theses

In general, tunnels are designed with an abundance of safety regarding structural integrity, however, there can be uncertainty related to structural performance after a fire event. The residual condition of a tunnel after a fire is dependent on fire intensity and duration. The goal of this study is to correlate visual and material characteristics of structural and non-structural components of tunnels with fire temperature and exposure time. This can be further related to the residual capacity of structural members in a tunnel, providing insight into safety and overall functionality. Experimental results show that the visual response of materials with heat …

Learning To Rig Characters, Zhan Xu

Doctoral Dissertations

With the emergence of 3D virtual worlds, 3D social media, and massive online games, the need for diverse, high-quality, animation-ready characters and avatars is greater than ever. To animate characters, artists hand-craft articulation structures, such as animation skeletons and part deformers, which require significant amount of manual and laborious interaction with 2D/3D modeling interfaces. This thesis presents deep learning methods that are able to significantly automate the process of character rigging. First, the thesis introduces RigNet, a method capable of predicting an animation skeleton for an input static 3D shape in the form of a polygon mesh. The predicted skeletons …

Design And Analysis Of Content Caching Systems, Anirudh Sabnis

Doctoral Dissertations

Caching is a simple yet powerful technique that has had a significant impact on improving the performance of various computer systems. From internet content delivery to CPUs, domain name systems, and database systems, caching has played a pivotal role in making these systems faster and more efficient. The basic idea behind caching is to store frequently accessed data locally, so that future requests for that data can be served more quickly. For example, a Content Delivery Network (CDN) like Akamai deploys thousands of edge caches across the globe, so that end-user requests can be served from a nearby cache, rather …

Additive Manufacturing Of High-Performance Nanolamellar Eutectic High-Entropy Alloys, Jie Ren

Doctoral Dissertations

Additive manufacturing, also called three-dimensional (3D) printing, is an emerging technology for printing net-shaped components layer by layer for applications in automotive, aerospace, biomedical and other industries. In addition to the vast design freedom offered by this approach, metal 3D printing via laser powder-bed fusion (L-PBF) involves large temperature gradients and rapid cooling and provides exciting opportunities for producing microstructures and mechanical properties beyond those achievable by conventional processing routes. Although these extreme printing conditions enable microstructural refinement to the nanoscale for achieving high strength. However, high-strength nanostructured alloys by laser additive manufacturing often suffer from limited ductility. Eutectic high-entropy …

Reprogramming And Imaging Of Tumor Associated Macrophages Using Spuramolecular Nanoparticles, Anujan Ramesh

Doctoral Dissertations

Macrophages are highly plastic cells that are a part of the mononuclear phagocytic system and play a crucial role in both the innate and the adaptive immune systems. Although they have functionally diverse roles involved in physiological and pathological processes, they primarily act as phagocytes that aid in clearing infections. During these instances of tissue injury or infections, circulating monocytes are recruited to the site of the injury, where they differentiate to give rise to macrophages that have a pro-inflammatory function. These monocytes derived macrophages, however, exist across a spectrum of phenotypes based on the local tissue environment. The two …

Capacity Planning For Heterogeneous Patient Populations In Primary Care And Specialty Networks, Prashant Meckoni

Doctoral Dissertations

Access to primary care has a direct impact on morbidity and mortality, and is strongly influenced by indirect waiting time: the delay between the requested and allotted appointment day. Our models describe the heterogeneous appointment seeking patterns of a primary care patient panel using stochastic processes parameterized to reflect the diversity of primary care visit rates in the US. For capacity planning, we estimate the distribution of daily appointments, and show that the distribution variability can be reduced by heuristics that use patient flexibility regarding the day of the appointment. For delays, we demonstrate that in a first-come, first-served system, …

A Digital Twin Framework For Production Planning Optimization: Applications For Make-To-Order Manufacturers, Ron Mallach

Doctoral Dissertations

In this dissertation, we develop a Digital Twin framework for manufacturing systems and apply it to various production planning and scheduling problems faced by Make-To-Order (MTO) firms. While this framework can be used to digitally represent a particular manufacturing environment with high fidelity, our focus is in using it to generate realistic settings to test production planning and scheduling algorithms in practice. These algorithms have traditionally been tested by either translating a practical situation into the necessary modeling constructs, without discussion of the assumptions and inaccuracies underlying this translation, or by generating random instances of the modeling constructs, without assessing …

Singular Integration By Interpolation For Integral Equations, Ioannis Kyriakou

Doctoral Dissertations

Maxwell’s equations and the laws of Electromagnetics (EM) govern a plethora of electrical, optical phenomena with applications on wireless, cellular, communications, medical and computer hardware technologies to name a few. A major contributor to the technological progress in these areas has been due to the development of simulation and design tools that enable engineers and scientists to model, analyze and predict the EM interactions in their systems of interest. At the core of such tools is the field of Computational Electromagnetics (CEM), which studies the solution of Maxwell’s equations with the aid of computers. The advances in these applications technologies, …

Enabling Novel Network Economics Using Multi-Hop, Asynchronous Resource Exchanges, Puming Fang

Doctoral Dissertations

Economic transactions typically involve only the parties directly involved, known as single-hop economic exchange. However, this model has limitations since only the final contributors participate in the resource exchange and acquire ownership of resources from previous contributors. In contrast, distributed systems aggregate resources from multiple entities across multiple hops. In Web 3.0, everyone can be a content creator and take ownership of their creations. To address this issue, we propose a value tree model that includes all contributors and enables multi-hop and asynchronous resource exchange. We propose two different approaches to implement the value tree model: value tree single contract, …

Polyesters Derived From Biobased 1,5-Pentanediol For Coatings, Adhesives, And Biodegradable Plastics, Lei Zheng

Doctoral Dissertations

Biomass-derived polymers are drawing increased attention from researchers due to unique performance attributes, potential for biodegradability, new low-cost feedstocks, and improved sustainability. Biobased feedstocks are employed in both major applications of polymers thermosets and thermoplastics. For thermoset coatings and adhesives, biobased resins such as biobased alkyds, epoxy resins, benzoxazine resins, starch derivatives, and proteins from plants and animals, are promising candidates to replace petroleum-derived counterparts. Thermoplastics such as polyethylene are mainly produced from fossil resources, generally have poor degradability and are difficult to effectively recycle. Currently, in the United States, less than 10% plastics are recycled, and more than 70% …

Polymer Based Energy Storage And Thermal Management On Textile Devices, Wesley A. Viola

Doctoral Dissertations

Humans developed textiles to manage thermal energy transfer with the environment and support homeostasis in a wide range of climates. With the anticipation of wearable technologies to transform healthcare via early, pre-symptomatic detection of illness, there is now a demand for electrical energy storage to support such on-body devices. Finding energy materials to merge seamlessly with textiles is basic requirement to ensure widespread adoption of wearable health monitors. Here we use a vapor deposition process to conformally coat ordinary fabrics with the doped conjugated polymer poly(3,4 ethylenedioxythiophene) (PEDOT-Cl), a soft material which possesses electronic and redox capabilities. We demonstrate PEDOT-Cl …

Assembly Of Polymer Colloids At Fluid Interfaces Through External Fields And Nanoscale Surface Topography, Samuel Trevenen

Doctoral Dissertations

The superposition of dipolar repulsion and capillary attraction energies between colloidal particles pinned at fluid interfaces dictates their microstructural organization and therefore the macroscopic interfacial material properties of particle-stabilized emulsions and 2D monolayer materials. While isotropic, spherical, particles have been extensively utilized, expanding the possible applications and material property tunability via anisotropic particles has been a challenge due to the propensity of particles to form disordered aggregates at the interface. My thesis presents the synthesis of anisotropic polymer ellipsoids and the development and use of experimental tools to study their interfacial behavior to reveal how dipolar and capillary interactions can …