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Articles 1 - 7 of 7
Full-Text Articles in Engineering
Advanced Materials Design Using Application-Based Processing Techniques, Daniel S. Camarda
Advanced Materials Design Using Application-Based Processing Techniques, Daniel S. Camarda
Doctoral Dissertations
This dissertation pertains to generating advanced materials using application-based processing techniques. First, billets consisting of PTFE sintering powders are evaluated using Thermomechancal Analysis. It was found that both shape change and volume change are associated with enthalpic and entropic recoil, respectively. These phenomena, due to melting and stored energy during the powder compaction process, were found to be molecular weight dependent. Additionally, kinetics of the recovery and sintering process were found to be slower in blended specimens than pure samples. Next, the creation of graft copolymers by selectively grafting a second polymer to the amorphous fraction of a semi-crystalline polymer …
Designing Stimuli-Responsive Nanocomposites To Investigate Interface Dynamics, Huyen Vu
Designing Stimuli-Responsive Nanocomposites To Investigate Interface Dynamics, Huyen Vu
Doctoral Dissertations
Inspired by nature, this research focuses on designing multifunctional renewable nanocomposites with high toughness and stimuli-responsiveness. In recent years, cellulose nanocrystals (CNCs) have been explored due to their abundance, renewable resource, and unique mechanical strength and structural coloration. CNCs naturally self-assemble into the helicoidal (Bouligand) structure that effectively endure high impacts but is brittle without an attendant soft phase. A thermoresponsive polymer, poly(diethylene glycol methyl ether methacrylate) (PMEO2MA), was incorporated into CNCs via evaporation-induced self-assembly to improve toughness of the resulting nanocomposites and to study responses in polymer dynamics under varying temperature and humidity conditions. To study microscopic …
Thermoelectric Transport In Disordered Organic And Inorganic Semiconductors, Meenakshi Upadhyaya
Thermoelectric Transport In Disordered Organic And Inorganic Semiconductors, Meenakshi Upadhyaya
Doctoral Dissertations
The need for alternative energy sources has led to extensive research on optimizing the conversion efficiency of thermoelectric (TE) materials. TE efficiency is governed by figure-of-merit (ZT) and it has been an enormously challenging task to increase ZT > 1 despite decades of research due to the interdependence of material properties. Most doped inorganic semiconductors have a high electrical conductivity and moderate Seebeck coefficient, but ZT is still limited by their high lattice thermal conductivity. One approach to address this problem is to decrease thermal conductivity by means of alloying and nanostructuring, another is to consider materials with an inherently low …
Enhancing The Intracellular Availability Of Protein Cargoes In Polymer-Mediated Delivery, Christopher R. Hango
Enhancing The Intracellular Availability Of Protein Cargoes In Polymer-Mediated Delivery, Christopher R. Hango
Doctoral Dissertations
Protein drugs, including antibodies, are rapidly emerging as the top-selling pharmaceuticals worldwide owing to their unparalleled specificity and biocompatibility. However, none of the currently-approved protein therapeutics act intracellularly, despite the vast majority of potential drug targets residing within the cell. This is due mainly to the paramount challenge of transporting hydrophilic macromolecular cargoes across the plasma membrane. As such, effective protein carriers are essential for the advancement of modern medicine. Despite significant advances, many challenges still plague protein delivery. Following membrane transduction, delivery vectors must preserve the structure and activity of their cargoes while transporting them to the correct subcellular …
Electrospinning Fibers Via Complex Coacervation, Xiangxi Meng
Electrospinning Fibers Via Complex Coacervation, Xiangxi Meng
Doctoral Dissertations
Electrospun fibers are high-surface-area materials widely used in applications ranging from batteries to wound dressings. Typically, an electrospinning precursor solution is prepared by dissolving a high-molecular-weight polymer in an organic solvent to form a sufficiently entangled solution. Our approach bypasses the requirement for entanglements and completely avoids toxic chemicals by focusing on using an aqueous complex coacervates solution. Coacervates are a dense, polymer-rich liquid phase resulting from the associative electrostatic complexation of oppositely charged macroions. We were the first to demonstrate that liquid complex coacervates could be successfully electrospun into polyelectrolyte complex (PEC) fibers. A canonical coacervate system was formed …
Raising Dielectric Permittivity Mitigates Dopant-Induced Disorder In Conjugated Polymers, Meenakshi Upadhyaya, Michael Lu-Díaz, Subhayan Samanta, Muhammad Abdullah, Keith Dusoe, Kevin R. Kittilstved, Dhandapani Venkataraman, Zlatan Akšamija
Raising Dielectric Permittivity Mitigates Dopant-Induced Disorder In Conjugated Polymers, Meenakshi Upadhyaya, Michael Lu-Díaz, Subhayan Samanta, Muhammad Abdullah, Keith Dusoe, Kevin R. Kittilstved, Dhandapani Venkataraman, Zlatan Akšamija
Electrical and Computer Engineering Faculty Publication Series
Conjugated polymers need to be doped to increase charge carrier density and reach the electrical conductivity necessary for electronic and energy applications. While doping increases carrier density, Coulomb interactions between the dopant molecules and the localized carriers are poorly screened, causing broadening and a heavy tail in the electronic density-of-states (DOS). The authors examine the effects of dopant-induced disorder on two complimentary charge transport properties of semiconducting polymers, the Seebeck coefficient and electrical conductivity, and demonstrate a way to mitigate them. Their simulations, based on a modified Gaussian disorder model with Miller-Abrahams hopping rates, show that dopant-induced broadening of the …
A Synergistic Anti-Diabetic Effect By Ginsenosides Rb1 And Rg3 Through Adipogenic And Insulin Signaling Pathways In 3t3-L1 Cells, Hee-Do Hong, Sun-Il Choi, Ok-Hwan Lee, Young-Cheul Kim
A Synergistic Anti-Diabetic Effect By Ginsenosides Rb1 And Rg3 Through Adipogenic And Insulin Signaling Pathways In 3t3-L1 Cells, Hee-Do Hong, Sun-Il Choi, Ok-Hwan Lee, Young-Cheul Kim
Nutrition Department Faculty Publication Series
Although ginsenosides Rb1 and Rg3 have been identified as the significant ginsenosides found in red ginseng that confer anti-diabetic actions, it is unclear whether insulin-sensitizing effects are mediated by the individual compounds or by their combination. To determine the effect of ginsenosides Rb1 and Rg3 on adipocyte differentiation, 3T3-L1 preadipocytes were induced to differentiate the standard hormonal inducers in the absence or presence of ginsenosides Rb1 or Rg3. Additionally, we determined the effects of Rb1, Rg3, or their combination on the expression of genes related to adipocyte differentiation, adipogenic transcription factors, and the insulin signaling pathway in 3T3-L1 cells using …