Engineering Commons^™

A Synergistic Anti-Diabetic Effect By Ginsenosides Rb1 And Rg3 Through Adipogenic And Insulin Signaling Pathways In 3t3-L1 Cells, Hee-Do Hong, Sun-Il Choi, Ok-Hwan Lee, Young-Cheul Kim

Nutrition Department Faculty Publication Series

Although ginsenosides Rb1 and Rg3 have been identified as the significant ginsenosides found in red ginseng that confer anti-diabetic actions, it is unclear whether insulin-sensitizing effects are mediated by the individual compounds or by their combination. To determine the effect of ginsenosides Rb1 and Rg3 on adipocyte differentiation, 3T3-L1 preadipocytes were induced to differentiate the standard hormonal inducers in the absence or presence of ginsenosides Rb1 or Rg3. Additionally, we determined the effects of Rb1, Rg3, or their combination on the expression of genes related to adipocyte differentiation, adipogenic transcription factors, and the insulin signaling pathway in 3T3-L1 cells using …