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Probing The Effect Of Hyperglycemia On Endothelial Force Generation And Transmission, Jovani J. Gutierrez
Probing The Effect Of Hyperglycemia On Endothelial Force Generation And Transmission, Jovani J. Gutierrez
Honors Undergraduate Theses
This thesis intends to utilize biomechanics to study the endothelial biomechanical response in a static hyperglycemic microenvironment. Hyperglycemia is a diabetic condition with abnormally high levels of glucose in the bloodstream. The effects of hyperglycemia over time lead to vascular complications resulting in patients being more prone to cardiovascular diseases. Current studies have focused on the molecular mechanisms affected by hyperglycemia; however, the mechanical mechanisms by which hyperglycemia causes vascular structural and functional changes are understudied. Therefore, to study the effects of hyperglycemia in the endothelium, Human Umbilical Vein Endothelial Cells (HUVEC) were cultured under three glucose conditions: normal glucose …
Mimicking Blood Rheology For More Accurate Modeling In Benchtop Research, Lindsey Webb
Mimicking Blood Rheology For More Accurate Modeling In Benchtop Research, Lindsey Webb
Honors Undergraduate Theses
To confirm computer simulations and Computational Fluid Dynamics (CFD) analysis, benchtop experiments are needed with a fluid that mimics blood and its viscoelastic properties. Blood is challenging to use as a working fluid in a laboratory setting because of health and safety concerns. Therefore, a blood analogue is necessary to perform benchtop experiments. Viscosity is an important property of fluids for modeling and experiments. Blood is a shear thinning fluid, so it has a decreasing viscosity with higher shear rates. This project seeks to create a blood mimicking fluid for benchtop laboratory use. Numerous fluids with different combinations of water, …