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University of Arkansas, Fayetteville

Theses/Dissertations

2020

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Full-Text Articles in Engineering

Exploring The Variability In The Gray Scale Imaging Process Of Asphalt Samples, David Oluwawade Olatunji Dec 2020

Exploring The Variability In The Gray Scale Imaging Process Of Asphalt Samples, David Oluwawade Olatunji

Civil Engineering Undergraduate Honors Theses

Gray scale image analysis is a powerful tool for testing asphalt concrete materials. From material composition to surface properties, gray scale analysis has shown evidence as a non-invasive way to obtain information from asphalt samples. Casillas et al. used a gray scale analysis to measure the Representative Volume Element of three asphalt sample geometries to understand the minimum size at which an asphalt sample is representative of a larger homogeneous mixture [1]. While the gray scale analysis used in this experiment yielded results, there were unknown factors in the image capturing process. Particularly, not much was known about the effect …


Ventilation And Recirculation Airway Design For An Autonomous, Climate Controlled, Hydroponic Demonstration Unit, Nicholas Cross Dec 2020

Ventilation And Recirculation Airway Design For An Autonomous, Climate Controlled, Hydroponic Demonstration Unit, Nicholas Cross

Biological and Agricultural Engineering Undergraduate Honors Theses

For this Honors Thesis project, I designed and fabricated a ventilation and recirculation airway sub-system prototype for a hydroponic demonstration unit to be used as an educational demonstration for prospective students, illustrating the capabilities of biological engineers. This thesis focuses on the design of an autonomous air system that toggles between ventilation and recirculation modes based upon sensor output. In the literature review I discuss how ventilation can be used to achieve a targeted climate, the benefits of hands-on projects for education, and the optimum parameters for growing herbs in a hydroponic system.

In the design and fabrication process, every …


Antenna Radiation Element Designs For 5g Applications, Zhijun Gui Dec 2020

Antenna Radiation Element Designs For 5g Applications, Zhijun Gui

Electrical Engineering Undergraduate Honors Theses

This thesis introduced the advantage of the fifth-generation network and gave examples to the three major classes of applications categorized by International Telecommunication Union-Radiocommunication Sector. In this work, a patch antenna and a board-band bow-tie antenna with microelectromechanical switch design were modified to meet 5G communication purposes. The revised patch antenna produced a minimum S11 of -57.92dB, a resonant frequency at the 28GHz, and bandwidth of 4.55GHz. The modified design meets the requirements for wireless communication purposes. During the duplication process of the board-band bow-tie antenna design, multiple discrepancies were found, and the proposed results were not able to achieve. …


Attitude Determination And Control Of Arksat-1, Jared Gilliam Dec 2020

Attitude Determination And Control Of Arksat-1, Jared Gilliam

Mechanical Engineering Undergraduate Honors Theses

ARKSAT-1 is a nanosatellite developed at the University of Arkansas as part of NASA’s CubeSat Launch Initiative (CSLI). The goal of ARKSAT-1 is to utilize an LED emitter paired with a ground-based tracking system to perform measurements of the composition of the atmosphere using spectroscopy. As part of its function, it is imperative that the satellite is able to control its orientation so that the emitter is aligned as closely as possible with the ground tracker. To do this, the attitude control system of ARKSAT-1 uses magnetic actuators to create a torque on the satellite by interacting with Earth’s magnetic …


Towards Sensorimotor Coupling Of A Spiking Neural Network And Deep Reinforcement Learning For Robotics Application, Kashu Yamazaki Dec 2020

Towards Sensorimotor Coupling Of A Spiking Neural Network And Deep Reinforcement Learning For Robotics Application, Kashu Yamazaki

Mechanical Engineering Undergraduate Honors Theses

Deep reinforcement learning augments the reinforcement learning framework and utilizes the powerful representation of deep neural networks. Recent works have demonstrated the great achievements of deep reinforcement learning in various domains including finance,medicine, healthcare, video games, robotics and computer vision.Deep neural network was started with multi-layer perceptron (1stgeneration) and developed to deep neural networks (2ndgeneration)and it is moving forward to spiking neural networks which are knownas3rdgeneration of neural networks. Spiking neural networks aim to bridge the gap between neuroscience and machine learning, using biologically-realistic models of neurons to carry out computation. In this thesis, we first provide a comprehensive review …


Numerical Simulations Of Directed Self-Assembly Methods In Di-Block Copolymer Films For Efficient Manufacturing Of Nanoscale Patterns With Long-Range Order, Joseph Hill Dec 2020

Numerical Simulations Of Directed Self-Assembly Methods In Di-Block Copolymer Films For Efficient Manufacturing Of Nanoscale Patterns With Long-Range Order, Joseph Hill

Graduate Theses and Dissertations

Directed self-assembly (DSA) of block copolymers (BCPs) has been shown as a viable method to achieve bulk fabrication of surface patterns with feature sizes smaller than those available through traditional photolithography. Under appropriate thermodynamic conditions, BCPs will self-assemble into ordered micro-domain morphologies, a desirable feature for many applications. One of the primary interests in this field of research is the application of thin-film BCPs to existing photolithography techniques. This “bottom-up” approach utilizes the self-assembled BCP nanostructures as a sacrificial templating layer in the lithographic process.

While self-assembly occurs spontaneously, extending orientational uniformity over centimeter-length scales remains a critical challenge. A …


Application Of Percentage Within Limits Concepts On A Balanced Mix Design Of Asphalt Mixtures, Elvis Alexander Castillo Camarena Dec 2020

Application Of Percentage Within Limits Concepts On A Balanced Mix Design Of Asphalt Mixtures, Elvis Alexander Castillo Camarena

Graduate Theses and Dissertations

Many agencies have incorporated rutting, and more recently cracking, laboratory test requirements in the design process of asphalt mixtures. The objective of each additional specification is to produce a balance between the stability and durability of the final product. Although a performance-engineered mixture design (PEMD), denoted here as a balanced mix design (BMD), offers compelling benefits, there is concern regarding the compatibility of the BMD with current construction practices. The objective of this work is to correlate a BMD method with realistic binder content construction tolerances by applying the concepts of a percent-within-limits (PWL) approach to field QC/QA. First, Chapter …


Investigation Of Electrospun Nanofibers For Separation Applications, Shu-Ting Chen Dec 2020

Investigation Of Electrospun Nanofibers For Separation Applications, Shu-Ting Chen

Graduate Theses and Dissertations

Electrospun membranes are an attractive alternative to flat sheet membranes as absorbent with numerous advantages like high porosity, large specific surface area and ease of functionalization. This doctoral dissertation focuses on fabricating novel polymeric membrane adsorbents for protein separations and ammonium ion removal. Three distinctly different preparation methods including UV-initiated polymerization, atom transfer radical polymerization, and mixed-matrix formation, have been employed to fabricate the electrospun membranes. Overall, this study aimed to develop electrospun membranes with excellent separation efficiency for application in protein purification and ammonium ion removal.

Chapter 2 details the stepwise development of weak anion exchange membranes and subsequent …


Behavior Of Concrete Structures Reinforced With High Strength Steel, Rahman S. Kareem Dec 2020

Behavior Of Concrete Structures Reinforced With High Strength Steel, Rahman S. Kareem

Graduate Theses and Dissertations

The structural strength and corrosion resistance of concrete members are improved when A1035 steel is used as the main reinforcement. The enhancement of A1035 is achieved by the modification of the composition and microstructure of the steel. Therefore, the behavior of concrete structures reinforced with high-performance steel (A1035) is different from those reinforced with the regular steel (A615). Concrete bridge decks reinforced with different amounts of A1035 were studied in this research program. The structural behavior of twelve concrete bridge decks reinforced with A615 Grade 420 (60 ksi) and A1035 Grade 830 (120 ksi) steel was investigated at both service …


High-Temperature Optoelectronic Device Characterization And Integration Towards Optical Isolation For High-Density Power Modules, Syam Madhusoodhanan Dec 2020

High-Temperature Optoelectronic Device Characterization And Integration Towards Optical Isolation For High-Density Power Modules, Syam Madhusoodhanan

Graduate Theses and Dissertations

Power modules based on wide bandgap (WBG) materials enhance reliability and considerably reduce cooling requirements that lead to a significant reduction in total system cost and weight. Although these innovative properties lead power modules to higher power density, some concerns still need to be addressed to take full advantage of WBG-based modules. For example, the use of bulky transformers as a galvanic isolation system to float the high voltage gate driver limits further size reduction of the high-temperature power modules. Bulky transformers can be replaced by integrating high-temperature optocouplers to scale down power modules further and achieve disrupting performance in …


Growth And Characterization Of Semiconductor Materials And Devices For Extreme Environments Applications, Abbas Sabbar Dec 2020

Growth And Characterization Of Semiconductor Materials And Devices For Extreme Environments Applications, Abbas Sabbar

Graduate Theses and Dissertations

Numerous industries require electronics to operate reliably in harsh environments, such as extreme high temperatures (HTs), low temperature (LT), radiation rich environments, multi-extreme, etc. This dissertation is focused on two harsh environments: HT and multi-extreme.

The first study is on HT optoelectronics for future high-density power module applications. In the power modules design, galvanic isolation is required to pass through the gate control signal, reject the transient noise, and break the ground loops. The optocoupler, which consists of a lighting emitting diode (LED) and photodetector (PD), is commonly used as the solution of galvanic isolation at room temperatures. There is …


A Methodological Framework To Evaluate Community Perceptions Of Economic And Safety Impacts Attributed To Highway Bypass And Widening Projects, Karla Diaz-Corro Dec 2020

A Methodological Framework To Evaluate Community Perceptions Of Economic And Safety Impacts Attributed To Highway Bypass And Widening Projects, Karla Diaz-Corro

Graduate Theses and Dissertations

Transportation practitioners have proposed the construction of highway bypass and widening projects in rural communities to address traffic-related problems that include noise pollution and congestion, among others. In the past, the construction of bypass projects has led community residents to raise concerns about potential decreases in business activity for businesses located along the bypassed road. For transportation organizations, it is essential to understand the economic, social, and safety impacts of transportation projects in terms of public perceptions as public input is a required part of the project planning phase. Moreover, it is recommended that agencies perform retrospective analyses of project …


Fractional Order Identification Method And Control: Development Of Control For Non-Minimum Phase Fractional Order System, Majid Abdullah Alhomim Dec 2020

Fractional Order Identification Method And Control: Development Of Control For Non-Minimum Phase Fractional Order System, Majid Abdullah Alhomim

Graduate Theses and Dissertations

The increasing use of renewable energy has resulted in the need for improved a dc-dc converters. This type of electronic-based equipment is needed to interface the dc voltages normally encountered with solar arrays and battery systems to voltage levels suitable for connecting three phase inverters to distribution level networks. As grid-connected solar power levels continue to increase, there is a corresponding need for improved modeling and control of power electronic converters. In particular, higher levels of boost ratios are needed to connect low voltage circuits (less than 1000 V) to medium voltage levels in the range of 13 kV to …


Optical Properties Of Ultrathin In(Ga)As/Gaas And In(Ga)N/Gan Quantum Wells, Yurii Maidaniuk Dec 2020

Optical Properties Of Ultrathin In(Ga)As/Gaas And In(Ga)N/Gan Quantum Wells, Yurii Maidaniuk

Graduate Theses and Dissertations

Recently, structures based on ultrathin quantum wells (QWs) began to play a critical role in modern devices, such as lasers, solar cells, infrared photodetectors, and light-emitting diodes. However, due to the lack of understanding of the formation mechanism of ultrathin QWs during the capping process, scientists and engineers cannot fully explore the potential of such structures. This study aims to investigate how structural parameters of ultrathin QWs affect their emission properties by conducting a systematic analysis of the optical properties of In(Ga)As/GaAs and In(Ga)N/GaN ultrathin QWs. Specifically, the analysis involved photoluminescence measurements combined with effective bandgap simulation, x-ray diffraction, and …


Moisture Monitoring Of A Clt Structure In A Southern Climate, Elizabeth Poblete Dec 2020

Moisture Monitoring Of A Clt Structure In A Southern Climate, Elizabeth Poblete

Graduate Theses and Dissertations

Understanding of moisture behavior in cross laminated timber (CLT) is critical to the widespread use of CLT in construction in the United States. Currently, very little data exists on the long-term impact of moisture on CLT. The objective of this research is to collect data regarding the long-term moisture variation in the CLT panel at the University of Arkansas Adohi Hall residence hall. The climate of Northwest Arkansas is different from previously monitored buildings, as they were in the Pacific Northwest. Comparatively, Northwest Arkansas has a warmer climate with higher average annual precipitation. Waterproofing efforts are usually employed to prevent …


Mechanical And Frictional Behavior Of Textured And Non-Textured Surfaces, Raghuram R. Santhapuram Dec 2020

Mechanical And Frictional Behavior Of Textured And Non-Textured Surfaces, Raghuram R. Santhapuram

Graduate Theses and Dissertations

Tribology is the study of surfaces where two objects are sliding against another. Significant energy is lost due to friction between the sliding surfaces. Therefore, developing or designing surfaces to minimize friction is critical for the durability and reliability of the mechanical components. Several researchers have identified that surface texturing at the nanoscale (nanotexture) would reduce the friction between the contacting surfaces. The nanotextured surfaces have several applications in microelectromechanical systems and nanoelectromechanical systems. This dissertation employs molecular dynamics simulations to investigate the frictional and mechanical response of nanotextured aluminum (Al) and Al/amorphous silicon (a-Si) composite surfaces.

This study determines …


Comparison Of Additively Manufactured And Wrought 17-4 Ph Stainless Steels In Ultra Low Cycle Fatigue, Timothy Strasser Dec 2020

Comparison Of Additively Manufactured And Wrought 17-4 Ph Stainless Steels In Ultra Low Cycle Fatigue, Timothy Strasser

Graduate Theses and Dissertations

Additive manufacturing (AM) processes allow for creation of complex geometries that are otherwise impractical to fabricate with traditional subtractive methods. AM technology has potential to improve the optimization of seismic lateral force resisting components which dissipate seismic energy through large plastic strains; however, the ultra low-cycle fatigue performance of AM metals are not yet well understood. Void formation during the AM fabrication process has potential to affect performance. This study compares the performance of heat-treated and non-heat-treated AM and wrought 17-4PH stainless steel in Ultra Low Cycle Fatigue. To understand ULCF performance differences between the AM and wrought specimens, post …


Static And Dynamical Properties Of Multiferroics, Sayed Omid Sayedaghaee Dec 2020

Static And Dynamical Properties Of Multiferroics, Sayed Omid Sayedaghaee

Graduate Theses and Dissertations

Since the silicon industrial revolution in the 1950s, a lot of effort was dedicated to the research and development activities focused on material and solid-state sciences. As a result, several cutting-edge technologies are emerging including the applications of functional materials in the design and enhancement of novel devices such as sensors, highly capable data storage media, actuators, transducers, and several other types of electronic tools. In the last two decades, a class of functional materials known as multiferroics has captured significant attention because of providing a huge potential for new designs due to possessing multiple ferroic order parameters at the …


The Varied Thermal Response Of Magnetic Iron-Oxide Nanoparticles During Induction Heating In Liquid And Solid-Liquid Phase Change Mediums, Joshua Tompkins Dec 2020

The Varied Thermal Response Of Magnetic Iron-Oxide Nanoparticles During Induction Heating In Liquid And Solid-Liquid Phase Change Mediums, Joshua Tompkins

Graduate Theses and Dissertations

This study investigates the induction heating response of uncapped iron oxide nanoparticles sonically dispersed as a nanofluid and mechanically distributed in solid phase change materials. The nanoparticles examined have a mean diameter of 14.42 nm and are magnetically heated in an alternating magnetic field at an amplitude of 72.6 kA/m at frequencies of 217, 303, and 397 kHz. Nanoparticle characterization was undertaken through transition electron microscopy, x-ray diffraction, and dynamic light scattering when in suspension. Carrier fluids were characterized through viscosity, heat capacity, and density measurements which were used in the calorimetric calculation of the specific absorption rate (SAR) of …


Understanding Radiation Resistance In Head And Neck Tumor Xenografts Using Diffuse Reflectance And Raman Spectroscopy, Sina Dadgar Dec 2020

Understanding Radiation Resistance In Head And Neck Tumor Xenografts Using Diffuse Reflectance And Raman Spectroscopy, Sina Dadgar

Graduate Theses and Dissertations

Each year, 800,000 new patients are diagnosed with head and neck squamous cell carcinoma (HNSCC), a majority of whom are treated with a combination of daily fractions of radiation and weekly chemotherapy sessions for up to seven weeks. Current methods to evaluate treatment response of individual patients are limited to anatomical measurements of tumor burden using CT scan or MRI 4-8 weeks after completion of treatment. However, earlier knowledge of radiation-response prior to or at early days after commencement of therapy can aid oncologist with escalating and de-escalating treatment plans for exceptionally non-responding and responding patients. Such a knowledge can …


Adhesion And Deformation Mechanisms Of Polydopamine And Polytetrafluoroethylene: A Multiscale Computational Study, Matthew Brownell Dec 2020

Adhesion And Deformation Mechanisms Of Polydopamine And Polytetrafluoroethylene: A Multiscale Computational Study, Matthew Brownell

Graduate Theses and Dissertations

Polydopamine (PDA) has been shown to bond via covalent bonding, van der Waals forces, and hydrogen bonding and is known to adhere strongly to almost any material. The application of PDA between a substrate and a PTFE surface coating has resulted in low friction and a greatly reduced wear rate. Previous research probing the capabilities and limitations of PDA/PTFE films have studied the wear and mechanical properties of the film, but the overall adhesive and deformation mechanisms remain unclear.

In this research, we investigate the tribological properties of PDA and PTFE molecules and composites from the atomic to the microscale …


Cement Stabilized Crushed Stone Base Course Strength And Stiffness Analysis, Andrew Deschenes Dec 2020

Cement Stabilized Crushed Stone Base Course Strength And Stiffness Analysis, Andrew Deschenes

Graduate Theses and Dissertations

Approximately 70 – 80% of state departments of transportations (DOTs) utilize the 1993 AASTHO Guide for Design of Pavement Structures (1993 AASHTO) [1] for structural design of pavements. A growing portion of DOT’s are beginning to implement the Mechanistic-Empirical Pavement Design Guide (MEPDG), referred to as AASHTOWare Pavement ME [2]. The 1993 AASHTO flexible guide applies empirically derived unitless strength values referred to as structural layer coefficients and structural numbers (SN) to pavement thickness and pavement types. The 1993 AASHTO rigid flexible guide utilizes the depth and strength of the concrete pavement, with the composite spring constant (kc), which is …


Development And Characterization Of Metal Contacts For Graded Composition Ingan Solar Cells, Reem E. Alhelais Dec 2020

Development And Characterization Of Metal Contacts For Graded Composition Ingan Solar Cells, Reem E. Alhelais

Graduate Theses and Dissertations

There is an increasing demand for high-power electronic components and optoelectronic devices with low-loss and high efficiency. III-nitride semiconductor materials have demonstrated great potential for high-power, high-frequency, and high-temperature applications because of their remarkable and wide-ranging electronic and physical properties. These material systems, including alloys of AlN, GaN, and InN, are currently being explored for their potential to develop efficient photovoltaic cells. They can potentially achieve higher efficiency because of their very high direct wide band edge, absorption coefficients, and resistance to defects. The compositionally graded Group III-nitride alloy allows access to a large range of energies by varying the …


The Effects Of Solution Condition On Virus Filtration Performance, Fnu Namila Dec 2020

The Effects Of Solution Condition On Virus Filtration Performance, Fnu Namila

Graduate Theses and Dissertations

Virus filtration is an integral part of the downstream purification of mammalian cell culture-derived biotherapeutics to assure the viral safety of the products. Virus filtration membranes remove viruses based on a size-exclusion mechanism. Commercial parvovirus filers possess unique membrane structure and are designed to remove smaller non-enveloped parvoviruses with size 18-26 nm. However, some filters face issues, such as pre-mature fouling, the decline of filtrate flux, and reduction in virus retention. This doctoral dissertation focused on identifying the factors that influence the filtrate flux and the virus retention capability of commercial virus filters. The effects of solution pH and ionic …


An Investigation Into The Effects Of Fly Ash On Freeze-Thaw Durability Prediction, Yancy Schrader Dec 2020

An Investigation Into The Effects Of Fly Ash On Freeze-Thaw Durability Prediction, Yancy Schrader

Graduate Theses and Dissertations

Air is purposefully entrained into concrete primarily to improve resistance to freeze-thaw deterioration while saturated with water. Air entraining admixtures (AEAs) are chemical admixtures designed to entrain air into the concrete to provide adequate resistance to the effects of freezing and thawing. One of the challenges associated with air entrainment in concrete is the interaction of an AEA with supplementary cementitious materials present in the concrete, particularly fly ash. Fly ash is a by-product of the coal fired electrical generation industry, and often contains residual unburned carbon and other components that can increase the AEA demand of a particular concrete …


An Impedimetric Aptasensing System For The Rapid Detection Of Salmonella Typhimurium, America Sotero Dec 2020

An Impedimetric Aptasensing System For The Rapid Detection Of Salmonella Typhimurium, America Sotero

Graduate Theses and Dissertations

Salmonella Typhimurium is a foodborne pathogen associated with raw and undercooked eggs, poultry, beef, fruits, and vegetables. In the United States, Salmonella is responsible for approximately 1.2 million illnesses, 23,000 hospitalizations, and 450 deaths annually. For many years, conventional detection methods such as culture-dependent and PCR-based methods have been the “golden standards” for the detection of this pathogen due to their high sensitivity and reliability. However, they still have some disadvantages such as long enrichment steps and high costs that need to be overcome. The development of a rapid and reliable method for the detection of S. Typhimurium is needed …


Effect Of Citric Acid On Slump, Compressive Strength, And Setting Time Of Belitic Calcium Sulfoaluminate Concrete, Israel Aguilar Rosero Dec 2020

Effect Of Citric Acid On Slump, Compressive Strength, And Setting Time Of Belitic Calcium Sulfoaluminate Concrete, Israel Aguilar Rosero

Graduate Theses and Dissertations

Belitic calcium sulfoaluminate (BCSA) cement has well established advantages related to fast setting time, fast strength gain, long-term strengths, shrinkage, and sustainability. Due to its fast setting and hardening, this type of cement has historically been used to repair concrete structures, highways, and runways. This work provides much needed guidance on establishing mix design criteria for BCSA cement. Guidance is also given on the effects of set retarders on strength, slump, and setting times. Citric acid and a phosphonic acid-based admixture were tested as retarders for different concrete mixtures. Three studies were performed. In the slump study five different water …


Fourier Transform Infrared Spectroscopy For The Measurement Of Gesn/(Si)Gesn, Solomon Opeyemi Ojo Dec 2020

Fourier Transform Infrared Spectroscopy For The Measurement Of Gesn/(Si)Gesn, Solomon Opeyemi Ojo

Graduate Theses and Dissertations

Photoluminescence (PL) and Electroluminescence (EL) characterization techniques are important tools for studying the optical and electrical properties of (Si)GeSn. Light emission from these PL and EL measurements provides relevant information on material quality, bandgap energy, current density, and device efficiency. Prior to this work, the in-house PL set-up of this lab which involves the use of a commercially-obtained dispersive spectrometer was used for characterizing both GeSn thin film and fabricated devices, but these measurements were limited by issues bordering on low spectral resolution, spectral artifacts, and poor signal-to-noise ratio (SNR) thereby resulting in the possible loss of vital information and …


Seismic Loading Effects Within Orthogonally Connected Steel Lateral Force Resisting Systems, Alhussin Faraj Aliwan Dec 2020

Seismic Loading Effects Within Orthogonally Connected Steel Lateral Force Resisting Systems, Alhussin Faraj Aliwan

Graduate Theses and Dissertations

Steel buildings located within seismically active regions require special design considerations to ensure public safety and prevent collapse during an extreme seismic event. Two commonly used steel systems are special moment frames (SMFs) and buckling-restrained braced frames (BRBFs). When two seismic systems share a common column in an orthogonal configuration (such as at a building corner), design specifications currently consider a 100+30 rule wherein the shared column is designed for 100% fuse demand in one direction, plus 30% fuse demand from the other direction. While this rule has been shown to be reasonable for elastic building response, a few studies …


Multiphoton Microscopy And Deep Learning Neural Networks For The Automated Quantification Of In Vivo, Label-Free Optical Biomarkers Of Skin Wound Healing, Jake D. Jones Dec 2020

Multiphoton Microscopy And Deep Learning Neural Networks For The Automated Quantification Of In Vivo, Label-Free Optical Biomarkers Of Skin Wound Healing, Jake D. Jones

Graduate Theses and Dissertations

Non-healing ulcerative wounds that occur frequently in diseases such as diabetes are challenging to diagnose and treat due to numerous possible etiologies and the variable efficacy of wound care products. With advanced age, skin wound healing is often delayed, leaving elderly patients at high risk for developing these chronic injuries. As it is challenging to discriminate age-related delays from disease-related chronicity, there is a critical need to develop new quantitative biomarkers that are sensitive to wound status. Multiphoton microscopy (MPM) techniques are well-suited for 3D imaging of epithelia and are capable of non-invasively detecting metabolic cofactors (NADH and FAD) without …