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Effect Of Training Datasets On Support Vector Machine Prediction Of Protein-Protein Interactions, Siaw Ling Lo, Cong Zhong Cai, Maxey Chung, Yu Zong Chen
Effect Of Training Datasets On Support Vector Machine Prediction Of Protein-Protein Interactions, Siaw Ling Lo, Cong Zhong Cai, Maxey Chung, Yu Zong Chen
Research Collection School Of Computing and Information Systems
Knowledge of protein-protein interaction is useful for elucidating protein function via the concept of 'guilt-by-association'. A statistical learning method, Support Vector Machine (SVM), has recently been explored for the prediction of protein-protein interactions using artificial shuffled sequences as hypothetical noninteracting proteins and it has shown promising results (Bock, J. R., Gough, D. A., Bioinformatics 2001, 17, 455-460). It remains unclear however, how the prediction accuracy is affected if real protein sequences are used to represent noninteracting proteins. In this work, this effect is assessed by comparison of the results derived from the use of real protein sequences with that derived …