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Full-Text Articles in Engineering
Implementation Of A New Monte Carlo Simulation Tool For The Development Of A Proton Therapy Beam Line And Verification Of The Related Dose Distributions, G A. P Cirrone, G Cuttone, S Guatelli, S Lo Nigro, B Mascialino, M G. Pia, L Raffaele, G Russo, M G. Sabini
Implementation Of A New Monte Carlo Simulation Tool For The Development Of A Proton Therapy Beam Line And Verification Of The Related Dose Distributions, G A. P Cirrone, G Cuttone, S Guatelli, S Lo Nigro, B Mascialino, M G. Pia, L Raffaele, G Russo, M G. Sabini
Susanna Guatelli
Using the Monte Carlo simulation tool GEANT4 we simulated the hadron-therapy beam line of the CATANA center. CATANA is the unique italian hadron-therapy facility in which 62 AMeV proton beams are used for the radiotherapeutic treatment of choroidal and iris melanomas. All the elements, such as diffusers, range shifters, collimators and detectors, typical of a proton-therapy line were modelled. The CATANA beam line provides an ideal environment for the experimental testing and validation of the software developed. The software architecture was developed, and now the validation of the software is in its final stage. Simulated ranges, energy distribution, depth and …
Monte Carlo Study Of The Energy Response And Depth Dose Water Equivalence Of The Moskin Radiation Dosimeter At Clinical Kilovoltage Photon Energies, C Lian, M Othman, D Cutajar, M Butson, Susanna Guatelli, Anatoly Rosenfeld
Monte Carlo Study Of The Energy Response And Depth Dose Water Equivalence Of The Moskin Radiation Dosimeter At Clinical Kilovoltage Photon Energies, C Lian, M Othman, D Cutajar, M Butson, Susanna Guatelli, Anatoly Rosenfeld
Susanna Guatelli
Skin dose is often the quantity of interest for radiological protection, as the skin is the organ that receives maximum dose during kilovoltage X-ray irradiations. The purpose of this study was to simulate the energy response and the depth dose water equivalence of the MOSkin radiation detector (Centre for Medical Radiation Physics (CMRP), University of Wollongong, Australia), a MOSFET-based radiation sensor with a novel packaging design, at clinical kilovoltage photon energies typically used for superficial/orthovoltage therapy and X-ray CT imaging. Monte Carlo simulations by means of the Geant4 toolkit were employed to investigate the energy response of the CMRP MOSkin …
Effect Of A Magnetic Field On The Track Structure Of Low-Energy Electrons: A Monte Carlo Study, M Bug, E Gargioni, Susanna Guatelli, S Incerti, H Rabus, R Schulte, Anatoly Rosenfeld
Effect Of A Magnetic Field On The Track Structure Of Low-Energy Electrons: A Monte Carlo Study, M Bug, E Gargioni, Susanna Guatelli, S Incerti, H Rabus, R Schulte, Anatoly Rosenfeld
Susanna Guatelli
The increasing use of MRI-guided radiation therapy evokes the necessity to investigate the potential impact of a magnetic field on the biological effectiveness of therapeutic radiation beams. While it is known that a magnetic field, applied during irradiation, can improve the macroscopic absorbed dose distribution of electrons in the tumor region, effects on the microscopic distribution of energy depositions and ionizations have not yet been investigated. An effect on the number of ionizations in a DNA segment, which is related to initial DNA damage in form of complex strand breaks, could be beneficial in radiation therapy. In this work we …
Comparison Of Nanodosimetric Parameters Of Track Structure Calculated By The Monte Carlo Codes Geant4-Dna And Ptra, P Lazarakis, M U. Bug, E Gargioni, S Guatelli, H Rabus, Anatoly B. Rosenfeld
Comparison Of Nanodosimetric Parameters Of Track Structure Calculated By The Monte Carlo Codes Geant4-Dna And Ptra, P Lazarakis, M U. Bug, E Gargioni, S Guatelli, H Rabus, Anatoly B. Rosenfeld
Susanna Guatelli
The concept of nanodosimetry is based on the assumption that initial damage to cells is related to the number of ionizations (the ionization cluster size) directly produced by single particles within, or in the close vicinity of, short segments of DNA. The ionization cluster-size distribution and other nanodosimetric quantities, however, are not directly measurable in biological targets and our current knowledge is mostly based on numerical simulations of particle tracks in water, calculating track structure parameters for nanometric target volumes. The assessment of nanodosimetric quantities derived from particle-track calculations using different Monte Carlo codes plays, therefore, an important role for …
Monte Carlo Simulation Of Interactions Of Radiation With Biological Systems At The Cellular And Dna Levels: The Geant4-Dna Project, S Chauvie, Z Francis, Susanna Guatelli, S Incerti, B Mascialino, G Montarou, P Moretto, P Nieminen, Maria Pia
Monte Carlo Simulation Of Interactions Of Radiation With Biological Systems At The Cellular And Dna Levels: The Geant4-Dna Project, S Chauvie, Z Francis, Susanna Guatelli, S Incerti, B Mascialino, G Montarou, P Moretto, P Nieminen, Maria Pia
Susanna Guatelli
No abstract provided.
Monte Carlo Study Of Mosfet Packaging, Optimised For Improved Energy Response: Single Mosfet Filtration, M Othman, D Cutajar, Nicholas Hardcastle, S Guatelli, Anatoly Rosenfeld
Monte Carlo Study Of Mosfet Packaging, Optimised For Improved Energy Response: Single Mosfet Filtration, M Othman, D Cutajar, Nicholas Hardcastle, S Guatelli, Anatoly Rosenfeld
Susanna Guatelli
Monte Carlo simulations of the energy response of a conventionally packaged single metal-oxide field effect transistors (MOSFET) detector were performed with the goal of improving MOSFET energy dependence for personal accident or military dosimetry. The MOSFET detector packaging was optimised. Two different ‘drop-in’ design packages for a single MOSFET detector were modelled and optimised using the GEANT4 Monte Carlo toolkit. Absorbed photon dose simulations of the MOSFET dosemeter placed in free-air response, corresponding to the absorbed doses at depths of 0.07 mm (Dw(0.07)) and 10 mm (Dw(10)) in a water equivalent phantom of size 30 x 30 x30 cm3 for …
Monte Carlo Study Of The Energy Response And Depth Dose Water Equivalence Of The Moskin Radiation Dosimeter At Clinical Kilovoltage Photon Energies, C Lian, M Othman, D Cutajar, M Butson, Susanna Guatelli, Anatoly Rosenfeld
Monte Carlo Study Of The Energy Response And Depth Dose Water Equivalence Of The Moskin Radiation Dosimeter At Clinical Kilovoltage Photon Energies, C Lian, M Othman, D Cutajar, M Butson, Susanna Guatelli, Anatoly Rosenfeld
Dean Cutajar
Skin dose is often the quantity of interest for radiological protection, as the skin is the organ that receives maximum dose during kilovoltage X-ray irradiations. The purpose of this study was to simulate the energy response and the depth dose water equivalence of the MOSkin radiation detector (Centre for Medical Radiation Physics (CMRP), University of Wollongong, Australia), a MOSFET-based radiation sensor with a novel packaging design, at clinical kilovoltage photon energies typically used for superficial/orthovoltage therapy and X-ray CT imaging. Monte Carlo simulations by means of the Geant4 toolkit were employed to investigate the energy response of the CMRP MOSkin …
Monte Carlo Study Of The Potential Reduction In Out-Of-Field Dose Using A Patient-Specific Aperture In Pencil Beam Scanning Proton Therapy, Stephen J. Dowdell, Benjamin Clasie, Nicolas Depauw, Peter E. Metcalfe, Anatoly B. Rosenfeld, Hanne M. Kooy, Jacob B. Flanz, Harald Paganetti
Monte Carlo Study Of The Potential Reduction In Out-Of-Field Dose Using A Patient-Specific Aperture In Pencil Beam Scanning Proton Therapy, Stephen J. Dowdell, Benjamin Clasie, Nicolas Depauw, Peter E. Metcalfe, Anatoly B. Rosenfeld, Hanne M. Kooy, Jacob B. Flanz, Harald Paganetti
Anatoly Rozenfeld
This study is aimed at identifying the potential benefits of using a patientspecific aperture in proton beam scanning. For this purpose, an accurate Monte Carlo model of the pencil beam scanning (PBS) proton therapy (PT) treatment head at Massachusetts General Hospital (MGH) was developed based on an existing model of the passive double-scattering (DS) system. The Monte Carlo code specifies the treatment head at MGH with sub-millimeter accuracy. The code was configured based on the results of experimental measurements performed at MGH. This model was then used to compare out-of-field doses in simulated DS treatments and PBS treatments. For the …
Monte Carlo Study Of Mosfet Packaging, Optimised For Improved Energy Response: Single Mosfet Filtration, M Othman, D Cutajar, Nicholas Hardcastle, S Guatelli, Anatoly Rosenfeld
Monte Carlo Study Of Mosfet Packaging, Optimised For Improved Energy Response: Single Mosfet Filtration, M Othman, D Cutajar, Nicholas Hardcastle, S Guatelli, Anatoly Rosenfeld
Dean Cutajar
Monte Carlo simulations of the energy response of a conventionally packaged single metal-oxide field effect transistors (MOSFET) detector were performed with the goal of improving MOSFET energy dependence for personal accident or military dosimetry. The MOSFET detector packaging was optimised. Two different ‘drop-in’ design packages for a single MOSFET detector were modelled and optimised using the GEANT4 Monte Carlo toolkit. Absorbed photon dose simulations of the MOSFET dosemeter placed in free-air response, corresponding to the absorbed doses at depths of 0.07 mm (Dw(0.07)) and 10 mm (Dw(10)) in a water equivalent phantom of size 30 x 30 x30 cm3 for …