Engineering Commons^™

Development And Analysis Of A Software Package To Quantify In Vivo Polyethylene Wear After Total Hip Arthroplasty, Allison Kinney, Catherine Ambrose

Allison Kinney

Since the first total hip arthroplasty (THA) in 1938, THA evolved and developed into one of the major concentrations of orthopaedic research. The typical hip implant device used today incorporates a femoral and an acetabular component that serve to replicate the anatomical and mechanical functions of the natural hip joint. However, several problems exist that can effect the function of the implant device. Wear in the polyethylene liner of the acetabular component of the total hip replacement device is known as one of the major factors that affects the longevity of total hip replacement devices. Both manual and computer-aided techniques …

Planning Evaluation Of Radiotherapy For Complex Lung Cancer Cases Using Helical Tomotherapy, Tomas Kron, Grigor Grigorov, Edward Yu, Slav Yartsev, Jeff Chen, Eugene Wong, George Rodrigues, Kris Trenka, Terry Coad, Glenn Bauman, Jake Van Dyk

Edward Yu

Lung cancer treatment is one of the most challenging fields in radiotherapy. The aim of the present study was to investigate what role helical tomotherapy (HT), a novel approach to the delivery of highly conformal dose distributions using intensity-modulated radiation fan beams, can play in difficult cases with large target volumes typical for many of these patients. Tomotherapy plans were developed for 15 patients with stage III inoperable non-small-cell lung cancer. While not necessarily clinically indicated, elective nodal irradiation was included for all cases to create the most challenging scenarios with large target volumes. A 2 cm margin was used …

Food Based Approaches For A Healthy Nutrition In Africa, Mamoudou Hama Dicko

Pr. Mamoudou H. DICKO, PhD

The latest estimates of the FAO demonstrate the problems of the fight against hunger. These problems are manifested by the ever-increasing number of chronically undernourished people worldwide. Their numbers during the 1999-2001 period were estimated at about 840 million of which 798 million live in developing countries. Sub-Saharan Africa alone represented 198 million of those. In this part of Africa the prevalence of undernourishment ranges from 5-34%, causing growth retardation and insufficient weight gain among one third of the children under five years of age and resulting in a mortality of 5-15% among these children. Malnutrition resulting from undernourishment is …

Standard-Deviation Minimization For Calibrating The Radii Of Spheres Attached To Atomic Force Microscope Cantilevers, Nancy Burnham, E Thoreson

Nancy A. Burnham

We describe an efficient method for determining the radii of spheres attached to atomic force microscope(AFM) cantilevers by minimizing the square root of the square error for a segment of circular arc cross-sectional data. The approach we present has benefits: (1) The method fits a function, with two fitting parameters, to a number of data points, rather than calculating the radius based on two points of cross-sectional data, (2) a fit is performed in a common spreadsheet application, using a solving feature, and (3) spheres of diameters 2 to 60 μm were measured to an accuracy of 9% and a …

Chemogenomic Profiling: Identifying The Functional Interactions Of Small Molecules In Yeast, Patrick Flaherty

Patrick Flaherty

Inkjet Printing For High Throughput Cell Patterning, Elisabeth Roth, Tao Xu, Mainak Das, Cassie Gregory, Jay Hickman, Thomas Boland

Thomas Boland

The adaptation of inkjet printing technology to the complex fields of tissue engineering and biomaterial development presents the potential to increase progress in these emerging technologies through the implementation of this high-throughput capability via automated processes to enable precise control and repeatability. In this paper, a method of applying high-throughput inkjet printing to control cellular attachment and proliferation by precise, automated deposition of collagen is presented. The results indicate that commercial inkjet printing technology can be used to create viable cellular patterns with a resolution of 350 microm through the deposition of biologically active proteins. This method demonstrates a combination …

Construction Of High- Density Bacterial Colony Arrays And Patterns By The Ink Jet Method, Tao Xu, Sevastioni Petridou, Eric Lee, Elisabeth Roth, Narendra Vyavahare, Jay Hickman, Thomas Boland

Thomas Boland

We have developed a method for fabricating bacterial colony arrays and complex patterns using commercially available ink-jet printers. Bacterial colony arrays with a density of 100 colonies/cm(2) were obtained by directly ejecting Escherichia coli (E. coli) onto agar-coated substrates at a rapid arraying speed of 880 spots per second. Adjusting the concentration of bacterial suspensions allowed single colonies of viable bacteria to be obtained. In addition, complex patterns of viable bacteria as well as bacteria density gradients were constructed using desktop printers controlled by a simple software program.

Tissue-Engineering Constructs, Using Photopolymerizable Hydrogels And Stereolithography.”, Busaina Dhariwala, Elaine Hunt, Thomas Boland

Thomas Boland

One of the most important aspects of tissue engineering is the design of the scaffold providing the mechanical strength and access to nutrients for the new tissue. For customized tissue engineering, it is essential to be able to fabricate three-dimensional scaffolds of various geometric shapes, in order to repair defects caused by accidents, surgery, or birth. Rapid prototyping or solid free-form fabrication (SFF) techniques hold great promise for designing three-dimensional customized scaffolds, yet traditional cell-seeding techniques may not provide enough cell mass for larger constructs. This article presents a novel attempt to fabricate three-dimensional scaffolds, using hydrogels combined with cell …