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Articles 1 - 30 of 74
Full-Text Articles in Engineering
Mechanical Properties Of Hydrated Acoustically Sensitive Alginate-Based Microcapsules Confined In A Microfluidic Device As A Function Of Size And Composition, Maryam Mobed-Miremadi, Mallika Keralapura, Tiffany Fong, Rogel Camba
Mechanical Properties Of Hydrated Acoustically Sensitive Alginate-Based Microcapsules Confined In A Microfluidic Device As A Function Of Size And Composition, Maryam Mobed-Miremadi, Mallika Keralapura, Tiffany Fong, Rogel Camba
Bioengineering
Understanding the mechanical properties of alginate-based microcapsules according to size and chemical composition allows researchers to zero in on the treatment and methods required to engineer optimized implantable alginate-based artificial cells for chemotherapy. Cross-linked medium viscosity alginate capsules ranging from 1.1% (w/v)-1.8% (w/v) in composition and 200 μm-1200 μm in size, encapsulating ultrasound contrast agents and blue dextran were compressed within a 40 μm high polydimethylsiloxane microfluidic device and subsequently examined using 2D microscopy for strain deformation aimed at the calculation of poisson ratios and volume loss postcompression. Results indicate a decrease in Poisson ratio as a function of alginate …
A Long-Term Hydrologically Based Dataset Of Land Surface Fluxes And States For The Conterminous United States: Update And Extensions, Ben Livneh, Eric A. Rosenberg, Chiyu Lin, Bart Nijssen, Vimal Mishra, Kostas M. Andreadis, Edwin P. Maurer, Dennis P. Lettenmaier
A Long-Term Hydrologically Based Dataset Of Land Surface Fluxes And States For The Conterminous United States: Update And Extensions, Ben Livneh, Eric A. Rosenberg, Chiyu Lin, Bart Nijssen, Vimal Mishra, Kostas M. Andreadis, Edwin P. Maurer, Dennis P. Lettenmaier
Civil, Environmental and Sustainable Engineering
This paper describes a publicly available, long-term (1915–2011), hydrologically consistent dataset for the conterminous United States, intended to aid in studies of water and energy exchanges at the land surface. These data are gridded at a spatial resolution of latitude/longitude and are derived from daily temperature and precipitation observations from approximately 20 000 NOAA Cooperative Observer (COOP) stations. The available meteorological data include temperature, precipitation, and wind, as well as derived humidity and downwelling solar and infrared radiation estimated via algorithms that index these quantities to the daily mean temperature, temperature range, and precipitation, and disaggregate them to 3-hourly time …
Pvcrov : An Experimental Platform For Multi-Robot Control Systems, Nicholas Prince, Gregory Roos, Jennifer Semones, Chase Traficanti
Pvcrov : An Experimental Platform For Multi-Robot Control Systems, Nicholas Prince, Gregory Roos, Jennifer Semones, Chase Traficanti
Mechanical Engineering Senior Theses
As the field of multi-robot control systems grows, the demand for flexible, robust and precise multi-robot testbeds increases. Up to this point, the testbeds that do exist for testing multi-robot controllers are often expensive, hard to deploy, and typically constrained to a single plane of motion. These constraints limit the capacity to conduct research which is why team Autonomously Controlled Electromechanical Systems (ACES) has created the PVCROV system. PVCROV is a low cost, underwater platform for testing multi-robot control systems. By utilizing an underwater environment, ACES created a testbed that is not constrained to a single plane of motion. Additionally, …
The Santa Clara, 2013-11-14, Santa Clara University
The Santa Clara, 2013-11-14, Santa Clara University
The Santa Clara
No abstract provided.
The Santa Clara, 2013-11-07, Santa Clara University
The Santa Clara, 2013-11-07, Santa Clara University
The Santa Clara
No abstract provided.
The Santa Clara, 2013-10-31, Santa Clara University
The Santa Clara, 2013-10-31, Santa Clara University
The Santa Clara
No abstract provided.
Advances In Homology Directed Genetic Engineering Of Human Pluripotent And Adult Stem Cells, Kalpith Ramamoorthi, Donald Curtis, Prashanth Asuri
Advances In Homology Directed Genetic Engineering Of Human Pluripotent And Adult Stem Cells, Kalpith Ramamoorthi, Donald Curtis, Prashanth Asuri
Bioengineering
The ability to introduce precise genomic modifications in human cells has profound implications for both basic and applied research in stem cells, ranging from identification of genes regulating stem cell self-renewal and multilineage differentiation to therapeutic gene correction and creation of in vitro models of human diseases. However, the overall efficiency of this process is challenged by several factors including inefficient gene delivery into stem cells and low rates of homology directed site-specific targeting. Recent studies report the development of novel techniques to improve gene targeting efficiencies in human stem cells; these methods include molecular engineering of viral vectors o …
The Santa Clara, 2013-10-24, Santa Clara University
The Santa Clara, 2013-10-24, Santa Clara University
The Santa Clara
No abstract provided.
The Santa Clara, 2013-10-17, Santa Clara University
The Santa Clara, 2013-10-17, Santa Clara University
The Santa Clara
No abstract provided.
The Santa Clara, 2013-10-10, Santa Clara University
The Santa Clara, 2013-10-10, Santa Clara University
The Santa Clara
No abstract provided.
The Santa Clara, 2013-10-03, Santa Clara University
The Santa Clara, 2013-10-03, Santa Clara University
The Santa Clara
No abstract provided.
Cross-Linked Alginate Film Pore Size Determination Using Atomic Force Microscopy And Validation Using Diffusivity Determinations, Cheryl Simpliciano, Larissa Clark, Behrokh Asi, Nathan Chu, Maria Mercado, Steven Diaz, Michel Goedert, Maryam Mobed-Miremadi
Cross-Linked Alginate Film Pore Size Determination Using Atomic Force Microscopy And Validation Using Diffusivity Determinations, Cheryl Simpliciano, Larissa Clark, Behrokh Asi, Nathan Chu, Maria Mercado, Steven Diaz, Michel Goedert, Maryam Mobed-Miremadi
Bioengineering
The deficit of organ donors has fueled the need for advances in tissue engineering and regenerative medicine. Microencapsulation in alginate immuno-isolation membranes has been used to treat many disabling metabolic disorders, namely, phenylketonuria, kidney failure and diabetes mellitus. Systematic nutrient flux determinations are hindered by the lack of experimental data on alginate-based membrane topography and the pore size thus preventing the full therapeutic potential of the bio-membranes to be reached. In this study, samples of cross-linked alginate membranes were subjected to the following analytical characterization: 1) pore size characterization using atomic force microscopy operated in contact mode to detect and …
The Santa Clara, 2013-09-26, Santa Clara University
The Santa Clara, 2013-09-26, Santa Clara University
The Santa Clara
No abstract provided.
Climate Change Impacts On Streamflow And Subbasin- Scale Hydrology In The Upper Colorado River Basin, Darren L. Ficklin, Edwin P. Maurer, Iris T. Stewert
Climate Change Impacts On Streamflow And Subbasin- Scale Hydrology In The Upper Colorado River Basin, Darren L. Ficklin, Edwin P. Maurer, Iris T. Stewert
Civil, Environmental and Sustainable Engineering
In the Upper Colorado River Basin (UCRB), the principal source of water in the southwestern U.S., demand exceeds supply in most years, and will likely continue to rise. While General Circulation Models (GCMs) project surface temperature warming by 3.5 to 5.6uC for the area, precipitation projections are variable, with no wetter or drier consensus. We assess the impacts of projected 21st century climatic changes on subbasins in the UCRB using the Soil and Water Assessment Tool, for all hydrologic components (snowmelt, evapotranspiration, surface runoff, subsurface runoff, and streamflow), and for 16 GCMs under the A2 emission scenario. Over the GCM …
The Trm2h : Detecting Protein-Protein Interactions By Engineering The Cell As A Biosensor, Elyse Shimomura, Paulina Perezalonso
The Trm2h : Detecting Protein-Protein Interactions By Engineering The Cell As A Biosensor, Elyse Shimomura, Paulina Perezalonso
Bioengineering Senior Theses
Protein-protein interactions regulate key cellular functions and cell signaling pathways in the body; biological systems can be disrupted by protein interactions or lack of interactions that cause cell dysfunction and can lead to disease or illness. However, studying these interactions is complex and difficult to quantify. In this project, we examine the interaction of two putative cancer biomarkers, Bax and PDCDS, using the tetracycline repressor-based mammalian two-hybrid system (trM2H). This in vivo system engineers the cell as a biosensor using methods of DNA cloning and mammalian cell transfections that easily detects and quantities the interaction of two proteins by the …
The Key Role Of Heavy Precipitation Events In Climate Model Disagreements Of Future Annual Precipitation Changes In California, David W. Pierce, Daniel R. Cayan, Tapash Das, Edwin P. Maurer, Norman L. Miller, Yan Bao, M. Kanamitsu, Kei Yoshimura, Mark A. Snyder, Lisa C. Sloan, Guido Franco, Mary Tyree
The Key Role Of Heavy Precipitation Events In Climate Model Disagreements Of Future Annual Precipitation Changes In California, David W. Pierce, Daniel R. Cayan, Tapash Das, Edwin P. Maurer, Norman L. Miller, Yan Bao, M. Kanamitsu, Kei Yoshimura, Mark A. Snyder, Lisa C. Sloan, Guido Franco, Mary Tyree
Civil, Environmental and Sustainable Engineering
Climate model simulations disagree on whether future precipitation will increase or decrease over California, which has impeded efforts to anticipate and adapt to human-induced climate change. This disagreement is explored in terms of daily precipitation frequency and intensity. It is found that divergent model projections of changes in the incidence of rare heavy (>60 mm day−1) daily precipitation events explain much of the model disagreement on annual time scales, yet represent only 0.3% of precipitating days and 9% of annual precipitation volume. Of the 25 downscaled model projections examined here, 21 agree that precipitation frequency will decrease by the …
Analyzing Surface Protein Expression And Internalization, William Truong, Josergio Zaragoza
Analyzing Surface Protein Expression And Internalization, William Truong, Josergio Zaragoza
Bioengineering Senior Theses
G-protein coupled receptors (GPCRs) are currently the largest class of membrane receptors and are targeted by a majority of the modern drug therapeutics. In addition, they partake in many physiological and pathological processes such as inflammation, growth, and hormone responses. Most importantly, GPCRs are targets of many disease-specific pathways such as Alzheimers, hypertension, leukemia, and depression. As a result, there is an immense interest in studying GPCRs as this area provides further knowledge into the specific disease pathways and allows the discovery of novel therapeutics. In order to have a better understanding of pathways, scientists have studied GPCR activation. The …
Investigation Of Thermal Properties And Latent Heat Reduction Mechanisms In Nanofluid Phase Change Materials, Aitor Zabalegui
Investigation Of Thermal Properties And Latent Heat Reduction Mechanisms In Nanofluid Phase Change Materials, Aitor Zabalegui
Mechanical Engineering Master's Theses
The thermal properties of paraffin-based nanofluids have been examined to investigate the use of enhanced phase change materials (PCMs) for thermal energy storage (TES). PCMs are promising for TES applications, but low thermal conductivity limits their rate of heat exchange with a working fluid. The nanofluid approach has been established as a method of thermal conductivity enhancement, but effects of particle addition on other thermal properties affecting TES are relatively ignored. Significant reduction in latent heat of fusion below traditional effective medium theory has been observed in nanofluids. An experimental study of paraffin nanofluids, containing various diameter multi-walled carbon nanotubes, …
Quikchill : Thermoelectric Water Cooler, Franz Louie Chua, Brandon Ohara, Rachel Reid, Bernadette Tong
Quikchill : Thermoelectric Water Cooler, Franz Louie Chua, Brandon Ohara, Rachel Reid, Bernadette Tong
Mechanical Engineering Senior Theses
Motivated by the increasing residential energy utilization projections and the fact that water and ice dispensers consume 20% of total refrigerator energy, a thermoelectric water chiller was designed to provide a more energy efficient alternative. Implementing the chiller under the sink provides a convenient means to source cold, filtered water, thereby eliminating the need for water and nice dispensers as well as filtering pitchers. The cooling chamber design integrates thermoelectric modules (TEMs), which operate on the Peltier effect to cool filtered water down to 14 [degrees] C. The implementation of TEMs reduced current dispenser energy consumption by 82.4%, from 91 …
Design, Fabrication, And Analysis Of A 3u Cubesat Platform, Todd Chun-Van Osdol, Charles Dorsey, Jake Hedlund, Thomas Hoye, Owen Jacobs, Kadja Klarreich-Giglio, Elliott Martin, Michael Ruiz, Michael Schlesselmann, Zachary Singh
Design, Fabrication, And Analysis Of A 3u Cubesat Platform, Todd Chun-Van Osdol, Charles Dorsey, Jake Hedlund, Thomas Hoye, Owen Jacobs, Kadja Klarreich-Giglio, Elliott Martin, Michael Ruiz, Michael Schlesselmann, Zachary Singh
Mechanical Engineering Senior Theses
The goal of this project is to develop a 3U CubeSat nanosatellite bus capable of short duration technology verification experiments while providing compelling handson student education opportunities. This 3U CubeSat platform has been prototyped by the design team in order to demonstrate its capabilities. This spacecraft, the Unspecified Payload Active Attitude Control Nanosatellite (UPAACN), is designed to perform a 3-6 month technology verification experiment for a NASA test component and an SCU single-axis attitude control system (AACS) in Low Earth Orbit (LEO). This project builds upon the flight heritage of SCU's Robotic Systems Laboratory (RSL) and improves its satellite development …
Ghana Footbridge Project, Kevin Leatham, Justin Mogannam
Ghana Footbridge Project, Kevin Leatham, Justin Mogannam
Civil, Environmental and Sustainable Engineering Senior Theses
Over the past 4 years, SCU civil engineering senior design teams have traveled to Ghana to help build the community and improve their quality of life. When the 2011-2012 team arrived back at SCU after their Ghana visit, they made the current project team aware of a very visible problem. Every winter a makeshift bridge that connects the village of Gambibgo and the town of Bolgatanga is washed away due to heavy downpours of rain. As a result, the people of Gambibgo do not have access to the market, healthcare, and sometimes even school. On the site visit, a site …
Shoutboard : A New Locative Social Network, Evan Havlisch, Ketan Kumar, Tovin Thomas
Shoutboard : A New Locative Social Network, Evan Havlisch, Ketan Kumar, Tovin Thomas
Computer Science and Engineering Senior Theses
This paper will illustrate the need for a better location based social network that utilizes the latest smartphone features. Over the course of this project, we created ShoutBoard. ShoutBoard is a way for people to share messages with the people geographically close by. We accomplish this by creating a system with a client-server architecture. The user will use the iPhone app or the website to interact with our server. The server will fetch messages that other users have posted and return them to the client. Within this document, we describe in detail the problem we wish to solve, the current …
Amperometric Detection Of Bioamines In Cancer Borealis Using Microchip Capillary Electrophoresis Integrated With Micellar Chromatography, Ajay Fernandez, Jason Howard, Christina Shuh
Amperometric Detection Of Bioamines In Cancer Borealis Using Microchip Capillary Electrophoresis Integrated With Micellar Chromatography, Ajay Fernandez, Jason Howard, Christina Shuh
Bioengineering Senior Theses
In order to study neuromodulation in Cancer borealis, commonly known as the Jonah crab, we designed a microchip capillary electrophoretic (CE) device with micellar electrokinetic chromatography (MEKC) to separate bioamines and detect their concentrations using amperometric detection (AD). The analysis will be used to characterize the bioamines: dopamine, octopamine, tyramine, serotonin, norepinephrine, and gammaaminobutyric acid (GABA). The device measures the concentration of bioamines in microdialysate samples taken directly from the pericardial cavity of the crab. The research on Jonah crabs will be applied to enhance our understanding of the crab neurology. Since the structure and in some instances, the function …
Formula Electric : Powertrain, Mark Allison, Bryan Bidwell, Stuart Hopson, Jackson Smith, Carlos Streegan, Dominic Villa
Formula Electric : Powertrain, Mark Allison, Bryan Bidwell, Stuart Hopson, Jackson Smith, Carlos Streegan, Dominic Villa
Interdisciplinary Design Senior Theses
The Santa Clara Formula Electric team designed, and manufactured a powertrain for an electric racecar according to the rules prescribed by the SAE International Formula Electric competition. The powertrain is divided into subsystems: the battery pack, battery pack cooling system, motor controller, and the motor. The battery pack was constructed, but full electrical connection of all cells were not made. The pack was not integrated with the motor and motor controller. In addition, due to time constraints, extensive testing could not be completed.
Microfluidic Detection Of Arsenic Contamination In Groundwater, Mary Reynolds, Kyle Perricone
Microfluidic Detection Of Arsenic Contamination In Groundwater, Mary Reynolds, Kyle Perricone
Bioengineering Senior Theses
The difficulty of detecting small quantities of arsenic in water currently threatens the health of millions of people worldwide, as long-term exposure to arsenic has been associated with both cancerous and noncancerous health risks. Existing technologies make it possible to very accurately quantify arsenic levels in water; however the expense, extensive training, and off-site analysis required by these methods impede wide scale use. Here, we report on research to develop an affordable and point-of-use microfluidic platform capable of detecting trace amounts of arsenic in groundwater samples. We intend this device to meet the World Health Organization's (WHO's) ASSURED criteria for …
Mobile Educational Forum, Suzanne Lien, Alexandria Shearer
Mobile Educational Forum, Suzanne Lien, Alexandria Shearer
Computer Science and Engineering Senior Theses
Good education is essential for youth around the world. However, many communities in the developing world do not have access to basic knowledge and resources, like HIV prevention, womens rights, and life skills. As a result, the youth in these communities grow up and face difficult substandard lives. The Mobile Educational Forum addresses these issues by enabling a central party to distribute educational information to youth in emerging markets by making use of resources they already have on hand--mobile phones. Through our mobile web application, young people not only receive valuable information, but are also able to engage in discourse …
Project Omoverhi : Low-Cost, Neonatal Incubator, Richard Fong, Guillermo Gallardo, William Jeffery, Danny Maeda, Gabriel Romero
Project Omoverhi : Low-Cost, Neonatal Incubator, Richard Fong, Guillermo Gallardo, William Jeffery, Danny Maeda, Gabriel Romero
Interdisciplinary Design Senior Theses
Project Omoverhi, since its beginning in 2010-2011, has been focused on creating an incubator that has the capability of operating completely off grid. This year the project has been focused on redesigning the original system to reduce the cost to approximately $1000. In addition to this we have designed and implemented a control system that enables the user to set a desired temperature which can be maintained to within 1 degree Celsius. Before the project is able to be completed further work must be done. The thermal storage system that was initially proposed by the original team still needs to …
Thermoelectric Cookstove, Christine Horman, Matthew Lee, Mark Wagner
Thermoelectric Cookstove, Christine Horman, Matthew Lee, Mark Wagner
Mechanical Engineering Senior Theses
A fuel efficient cookstove tailored to the needs of Nicaraguan small business owners that incorporated insulation and thermoelectric power generation was built and validated. There is a 4 inch layer of pumice rock insulation around the combustion chamber, which significantly reduces convective heat losses to the environment. The stove's ventilation system is powered by the electricity generated by thermoelectric generators. Preheated air is forced into the combustion chamber, which increases the combustion efficiency, reducing the fuel consumption and the harmful smoke produced. Through various testing methods, we found that the controlled airflow to the charcoal fuel allows the stove to …
The Squad : Santa Clara Quadrotor Autonomous Drone, Jacob Adams, Peter Baumgartner, Mark Johnson, Michael Mccormick
The Squad : Santa Clara Quadrotor Autonomous Drone, Jacob Adams, Peter Baumgartner, Mark Johnson, Michael Mccormick
Mechanical Engineering Senior Theses
We have constructed a quadrotor unmanned aerial vehicle (UAV) that could be used to supplement emergency response personnel, including police and military, when in the field. The SQUAD focused primarily on designing and constructing a sound structure for the UAV, as well as beginning controls work, which will be continued by another team at a later date. This quadrotor UAV has a video camera to provide a live video from its point of view to the user. It carries a global positioning system (GPS) to provide information on its location, and to navigate to waypoints in the immediate area. The …
Cerberus : A Human Powered Vehicle, Colin Austin, Miles Graugnard, Max Herrmannsfeldt, Dane Kornasiewicz, Leif Kjos, Terra Oldham, Toban Platt, Theodore Schapp, Sean Smith
Cerberus : A Human Powered Vehicle, Colin Austin, Miles Graugnard, Max Herrmannsfeldt, Dane Kornasiewicz, Leif Kjos, Terra Oldham, Toban Platt, Theodore Schapp, Sean Smith
Mechanical Engineering Senior Theses
A recumbent trike was designed and built for the ASME Human Powered Vehicle Challenge held at San Jose State University in April of 2013. The vehicle was designed to be low cost for use by commuters and as primary transportation in developing countries. The vehicle placed 11th overall in the competition out of 29 teams, and scored 8th in the innovation event, which was its best ranking out of the 5 individual events.