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A Tale Of Two Nucleases: Using Talens To Edit The Genome Of C. Elegans, Clare Bartlett, Kriszten Kocmond, Erin Root
A Tale Of Two Nucleases: Using Talens To Edit The Genome Of C. Elegans, Clare Bartlett, Kriszten Kocmond, Erin Root
Bioengineering Senior Theses
Genetic engineering is an emerging technology that offers the potential to prevent, treat, or cure genetic diseases. The technology can permanently alter the genome, providing an alternative therapy to drugs and surgery. Specifically, gene therapy is a promising treatment option for many incurable genetic diseases, such as cystic fibrosis and muscular cell dystrophy. Our project gives rise to a better understanding of TALENs and its uses in the genetic engineering field. TALENs, transcription activator-like effector nucleases, are a genetic engineering technology that can be used for targeted gene modification. They are engineered proteins that can bind to specific sequences of …
Micro-Motion Controller Ii, Bergren Antell, Michael Mcnaul, Steve Shushnar
Micro-Motion Controller Ii, Bergren Antell, Michael Mcnaul, Steve Shushnar
Bioengineering Senior Theses
The purpose of this project was to improve upon the functionality of a micro-motion controller designed by another senior design group at this university. The original controller design facilitated motion in only two dimensions, and by modifying the platform of the design to accommodate another axis of rotation, we were able to achieve a full range of 3-D motion in our own product. Additionally, we designed a new system in which a motor could be mounted on the base plate of the device which would rotate the upper platform on its own through a simple belt-and-pulley system. And lastly, we …
Assured Bacterial Detection Towards Paper-Based Microfluidic Chip For Resource-Limited Areas, William Leineweber, Mallory Williams
Assured Bacterial Detection Towards Paper-Based Microfluidic Chip For Resource-Limited Areas, William Leineweber, Mallory Williams
Bioengineering Senior Theses
There is a significant and urgent need for affordable, fast, and accurate pathogen detection methods in resource-limited settings. Currently, accurate pathogen detection methods are dependent upon special equipment or reagents, specialized training to operate such equipment, electricity or cold storage, or sterile environments not feasible outside of the laboratory. Here we present a functionalized cellulose paper device towards an autonomous 3- dimensional microfluidics chip to detect bacterial pathogens. The microfluidic device utilizes a nucleic acid sandwich assay that detects the presence of bacterial RNA through complementary strand binding. An oligonucleotide “capture strand” immobilizes the targeted RNA sequence to the device, …