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Advanced Processing Techniques For Electrospun Nanofibers: Investigating Annealing And Laser Zone-Drawing Effects On Material Characteristics, Matthew D. Flamini
Advanced Processing Techniques For Electrospun Nanofibers: Investigating Annealing And Laser Zone-Drawing Effects On Material Characteristics, Matthew D. Flamini
Theses and Dissertations
Electrospun nanofibers hold potential for a wide range of commercial and scientific applications; however, their properties must be optimized through post-processing treatments to achieve optimal performance. This dissertation investigates the effects of annealing and laser zone-drawing on electrospun nanofiber properties. Annealing polycaprolactone nanofibers at 70°C results in the highest rate of crystallization and molecular alignment, impacting long-term stability and mechanical properties. A multivariate linear model incorporating crystallinity and molecular alignment predicts the material properties resulting from annealing under different conditions. Laser zone-drawing experiments reveal that polylactide fiber thinning under laser irradiation primarily occurs due to drawing rather than ablation. Steady-state …
Polyethyleneimine Shell Nucleic Acid Nanostructures From Gold Nanoparticle Template For Chemotherapeutic Drug Delivery, Brendan Guy Rucci
Polyethyleneimine Shell Nucleic Acid Nanostructures From Gold Nanoparticle Template For Chemotherapeutic Drug Delivery, Brendan Guy Rucci
Theses and Dissertations
The next generation of anticancer agents will emerge from rationally designed nanostructured materials. This work involved the synthesis and characterization of novel hollow DNA-conjugated gold nanoparticles (DNA-AuNPs) for controlled drug delivery. Polyethyleneimine (PEI) was bound to citrate-capped AuNPs, forming polymer-shell nanoparticles. Dissolution of the gold core via iodine formed hollow core polymeric nanoparticles (HCPPs) and a high density of DNA (85 molecules/particle) containing daunorubicin was conjugated. Particles were spherical with an average diameter of 105.7±17.3 nm and zeta potential of 20.4±3.54 mV. We hypothesize the DNA backbone electrostatically condensed to the primary amines on the surface of the particle toroidally, …