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Full-Text Articles in Engineering

Design And Analysis Of Flexible Insulated Pavement For Cold Region Applications, Zhuang Zhuo Dec 2021

Design And Analysis Of Flexible Insulated Pavement For Cold Region Applications, Zhuang Zhuo

Theses and Dissertations

Pavements in cold regions suffer from additional deterioration due to the influences of extreme climate on frost-susceptible subgrade layers. To address this problem, one efficient strategy is to add a thermal insulating layer above the frost-susceptible layer. This study aims to evaluate the insulating effects of four materials: XPS boards, tire chips, foamed glass aggregates, and foamed concrete. Large-scale insulated pavement boxes (1.2m×1.2m×0.8m) were constructed to compare the thermal performance of different materials. The thermal performance of each box was evaluated and graded based on indicators related to the short-term temperature decrease and long-term temperature variation.

Experimental results show that …


Enhancing Situational Awareness For Rotorcraft Pilots Using Virtual And Augmented Reality, Ardit Pranvoku Dec 2021

Enhancing Situational Awareness For Rotorcraft Pilots Using Virtual And Augmented Reality, Ardit Pranvoku

Theses and Dissertations

Rotorcraft pilots often face the challenge of processing a multitude of data, integrating it with prior experience and making informed decisions in complex, rapidly changing multisensory environments. Virtual Reality (VR), and more recently Augmented Reality (AR) technologies have been applied for providing users with immersive, interactive and navigable experiences. The research work described in this thesis demonstrates that VR/AR are particularly effective in providing real-time information without detracting from the pilot's mission in both civilian and military engagements. The immersion of the pilot inside of the VR model provides enhanced realism. Interaction with the VR environment allows pilots to practice …


Unsupervised Learning For Anomaly Detection In Remote Sensing Imagery, Husam A. Alfergani Sep 2021

Unsupervised Learning For Anomaly Detection In Remote Sensing Imagery, Husam A. Alfergani

Theses and Dissertations

Landfill fire is a potential hazard of waste mismanagement, and could occur both on and below the surface of active and closed sites. Timely identification of temperature anomalies is critical in monitoring and detecting landfill fires, to issue warnings that can help extinguish fires at early stages. The overarching objective of this research is to demonstrate the applicability and advantages of remote sensing data, coupled with machine learning techniques, to identify landfill thermal states that can lead to fire, in the absence of onsite observations. This dissertation proposed unsupervised learning techniques, notably variational auto-encoders (VAEs), to identify temperature anomalies from …


Investigation Of Distracted Driving Events In New Jersey, Ahmed Sajid Hasan Sep 2021

Investigation Of Distracted Driving Events In New Jersey, Ahmed Sajid Hasan

Theses and Dissertations

Every year, thousands of people die in the United States due to crashes involving distracted driving, with this cause contributing to 25% of all fatal traffic crashes in New Jersey in particular. Over the past several years, various techniques (e.g., surveys, crash reports, videos, and simulations) were developed and implemented by the transportation safety community to identify and evaluate distracted driving events. However, these methods collect cross-sectional data on individual subjects and do not provide the actual number of distractions on the road. To fill this gap, this study collected longitudinal data on distracted driving events in the state of …


Delivery Optimization And Evaluation Of Biomechanics Of An Injectable Nucleus Pulposus Replacement Device, Zachary Rustin Brown Sep 2021

Delivery Optimization And Evaluation Of Biomechanics Of An Injectable Nucleus Pulposus Replacement Device, Zachary Rustin Brown

Theses and Dissertations

Lower back pain effects up to 80% of people at some point in their life, a majority of cases being the result of degenerative disc disease. Treatment options for degenerative disc disease are limited, jumping from physical therapy to major spinal fusion and total disc replacement surgery with little to no approaches in between. Furthermore, surgical treatments have not shown to be more effective than conservative treatments and reducing pain and disability over the long term. Hydrogels have shown promise as a potential nucleus pulposus replacement device. Their properties are controllable and can be implanted into the body through minimally …


Fabrication And Comparative Study Of Horizontal And Vertical Electrospun Protein-Polysaccharide Nanofiber Biomaterials, Ashley Rivera-Galleti Sep 2021

Fabrication And Comparative Study Of Horizontal And Vertical Electrospun Protein-Polysaccharide Nanofiber Biomaterials, Ashley Rivera-Galleti

Theses and Dissertations

The use of biocompatible and biodegradable composite materials for biomedical applications has attracted the attention of many researchers in the past few years. In this study, we fabricated nanofibers of silk fibroin and cellulose and its derivatives to amalgamate their unique properties into a single material. The production of these nanofibers via electrospinning is of particular interest, and whereas several studies have been done on normal nanofibers, the formation of branched nanofibers is an exciting area not currently explored. Blend solutions are formed by dissolving silk and cellulose/cellulose acetate in formic acid separately and mixing to achieve the desired ratios. …


Design Of A Custom Digital Light Projection Printer For In-Situ Production Of Composites With Improved Thermomechanical Properties, Margaret Anne Gillan Sep 2021

Design Of A Custom Digital Light Projection Printer For In-Situ Production Of Composites With Improved Thermomechanical Properties, Margaret Anne Gillan

Theses and Dissertations

This work seeks to improve upon the existing state-of-the-art for vat photopolymerization additive manufacturing; namely, producing in-situ composites that combine the precision and high-performance materials of the vat photopolymerization with the strength of fiber-reinforced polymer composites. A custom-designed digital light projection printer was designed and built for printing composites, which includes an automated fiber tape system to place woven E-glass fiber mats in-situ. To validate the performance improvement of composites versus the neat matrix, composites were fabricated on the custom printer with hand-placed fiber mats. A high-performance, dual-cure resin was used for these studies. The effect of layer height on …


Rainbow Trapping Effect In 2d Axisymmetric Broadband Acoustic Energy Harvesters, Louis Alexander Gormley Sep 2021

Rainbow Trapping Effect In 2d Axisymmetric Broadband Acoustic Energy Harvesters, Louis Alexander Gormley

Theses and Dissertations

Acoustic energy harvesters (AEHs) collect otherwise unused ambient acoustic waves for conversion into useful electrical energy. This promising technology has potential applications ranging from grid-independent electronics to structural health monitoring systems. AEHs capture specific acoustic frequencies of interest using structures with frequency-matched component geometries. Despite the multitude of potential geometries suitable for AEH structures, existing AEH research has predominantly focused on the acoustic wave trapping performance of unidimensional or linear bidimensional AEH structures.

This study intended to broaden AEH bandwidth and capture efficiency by investigating the acoustic rainbow trapping performance of a novel 2D axisymmetric AEH design. A Finite Element …


Engineering A High-Throughput Screening Platform For Assessing Developmental Neurotoxicity Throughout Head- Regeneration In Schmidtea Mediterranea, Johnathan James Morris Sep 2021

Engineering A High-Throughput Screening Platform For Assessing Developmental Neurotoxicity Throughout Head- Regeneration In Schmidtea Mediterranea, Johnathan James Morris

Theses and Dissertations

The increase in commercially used chemicals that are inadequately evaluated for safety and risk to development has created a reticent threat to human health. Addressing these deficiencies is compounded by limited methodologies to determine the etiology of exposure-related developmental neurotoxicity (DNT). Current means of assessing DNT are largely retrospective and limited by the expensive, time-consuming, and labor-intensive use of laboratory animal models, thereby motivating a global research effort to produce alternative chemical screening assays. In this work, we have developed a novel high- throughput platform that serves as a new tool to evaluate the effects of exogenous chemical exposure on …


Design Of An Inexpensive Pvc Shock Tube For Educational Use, Brandon Edward Bergmann Aug 2021

Design Of An Inexpensive Pvc Shock Tube For Educational Use, Brandon Edward Bergmann

Theses and Dissertations

Herein is described the design and function of a low-cost, easy-to-assemble, -operate, and -disassemble shock tube platform experiment that can generate shock waves approaching Mach 2 at maximum pressures of ~100 psig with a helium driver gas. The experiment uses several inexpensive (<$5), unamplified piezoelectric sensors attached to a multichannel oscilloscope to monitor the passage of key features of the flow (i.e., incident shock and reflected shock) through the tube, constructed from inexpensive and easy to work with schedule 40 PVC pipe and fittings. From the fixed sensor displacements along the tube and relative differences in respective transit times, the velocities of these flow features can be determined. This permits (1) comparison of experimental results to the theoretical predictions of 1-D transient gas dynamics and (2) a leaping off point for discussion and quantification of non-idealities in the flow, including the shock wave development length, shock attenuation and boundary layer growth, and interactions of the reflected shock and contact surface. Experimental accessories (future work) for study of shock focusing and steady 2-D high speed flows are also briefly discussed. Assuming both pressurized, conditioned air at ~80-100 psig and a modern multi-channel oscilloscope are available at most institutions, the total cost to construct this experiment is around $500.


An Examination Of The Influence Of Distillation On The Combustion Behavior Of Apparently Equivalent Surrogate Fuels, Jay A. Lefkowitz Aug 2021

An Examination Of The Influence Of Distillation On The Combustion Behavior Of Apparently Equivalent Surrogate Fuels, Jay A. Lefkowitz

Theses and Dissertations

Use of surrogates to emulate the combustion behaviors of prevaporized real fuels has been widely demonstrated in the literature. However, many combustion applications utilize atomized fuel sprays, and for these configurations, the assumption of fuel property homogeneity in prevaporized fuel combustion is tenuous. This work uses a simplified distilling droplet model to demonstrate a real potential for vaporization-coupled deviations from the single-valued combustion property targets used to characterize prevaporized combustion behaviors. To verify the model-based observations, flame blowout measurements from a custom-built annular spray burner rig are measured. Sets of essentially equivalent prevaporized jet fuel and gasoline surrogates suggested in …


Laboratory And Full-Scale Pavement Sections Testing For Evaluating Frost Action In Cold Regions, Dorin Papuc Jul 2021

Laboratory And Full-Scale Pavement Sections Testing For Evaluating Frost Action In Cold Regions, Dorin Papuc

Theses and Dissertations

A comprehensive laboratory testing plan was conducted as part of this project to select two frost-susceptible soils for use in constructing three full-scale test strips. A total of 16 soils were obtained from various suppliers in NJ and were evaluated to determine their frost-susceptibility. The evaluation included conducting sieve analysis, hydrometer analysis, and specific gravity. Using these measures, two soils were selected (namely, Soil #2 and Soil #13) for constructing the test strips. The properties (Atterberg Limits, moisture-density relationships, California bearing ratio (CBR), Resilient Modulus among others) were determined through a laboratory testing plan. In addition, this study involved constructing …


Optimization Of Load-Bearing And Impact Energy Absorption Capacities Of Honeycomb Structures By Density Gradation, Oyindamola Khadijat Rahman Jul 2021

Optimization Of Load-Bearing And Impact Energy Absorption Capacities Of Honeycomb Structures By Density Gradation, Oyindamola Khadijat Rahman

Theses and Dissertations

Density gradation has been analytically and experimentally proven to enhance the load-bearing and energy absorption efficiency of cellular solids. This research focuses on the analytical optimization (by virtual experiments) of polymeric honeycomb structures made from flexible thermoplastics to achieve density-graded structures with desired mechanical properties. The global stress-strain curves of single-density honeycomb structures are used as input to an analytical model that enables the characterization of the constitutive response of density-graded hexagonal honeycombs with discrete and continuous gradations and for various gradients. The stress-strain outputs are used to calculate the specific energy absorption, efficiency, and ideality metrics for all density-graded …


Helipad Detection From Satellite Imagery Using Convolutional Neural Networks, David Specht Jun 2021

Helipad Detection From Satellite Imagery Using Convolutional Neural Networks, David Specht

Theses and Dissertations

Location data about U.S. heliports is often inaccurate or nonexistent in the FAA's databases, which leaves pilots and air ambulance operators with inaccurate information about where to find safe landing zones. In the 2018 FAA Reauthorization Act, Congress required the FAA to collect better information from the helicopter industry under part 157, which covers the construction, alteration, activation and deactivation of airports and heliports. At the same time, there is no requirement to report private helipads to the FAA when constructed or removed, and some public heliports do not have up to date records. This thesis proposes an autonomous system …


A Laboratory Investigation Of High Polymer Modified Asphalt Mixtures With Softening Agent, Basel K. Al-Badr Jun 2021

A Laboratory Investigation Of High Polymer Modified Asphalt Mixtures With Softening Agent, Basel K. Al-Badr

Theses and Dissertations

This study was initiated to evaluate the impact of aging and High Polymer Modified Asphalt (HPMA) binders containing a bio-based-oil softening agent (SA) on the rutting, cracking, and durability of asphalt mixtures. One control asphalt binder (PG 52-34), Styrene-Butadiene-Styrene (SBS) polymer modifier, and corn-oil SA were used to produce four asphalt mixtures including a control prepared using PG 52-34 binder and three modified mixtures were produced by blending PG 52-34 binder with different dosages of SBS and SA. The mixtures were tested using the Dynamic Complex Modulus (|E*|), Hamburg Wheel Tracking Device (HWTD), Flow Number (FN), Indirect Tension Cracking Test …


Effects Of Stiffness And Cell Shape On Cellular Mechanosensing, Sarah Lynn Furman Jun 2021

Effects Of Stiffness And Cell Shape On Cellular Mechanosensing, Sarah Lynn Furman

Theses and Dissertations

Cellular mechanosensing is the process of converting mechanical signals into biological responses. Stem cells are self-renewing cells with the potential to transform into specialized cell types - this differentiation process is influenced by cellular mechanosensing. Cells sense material stiffness, and stiffer environments result in increased cellular mechanosensing and preferential differentiation into bone-producing osteoblasts. Cell shape also plays an important role due to its influence on cytoskeletal contractility, and photopatterning can be used to study the effects of cell shape on cellular mechanosensing. Although the effects of material stiffness and cell shape have been studied, little is known about the joint …


Porous Scaffold And Soft Hydrogel Composite For Biomedical Applications, Matthew Dicerbo Jun 2021

Porous Scaffold And Soft Hydrogel Composite For Biomedical Applications, Matthew Dicerbo

Theses and Dissertations

Biophysical signals including stiffness and dimensionality influence a myriad of stem cell behaviors including morphology, mechanosensing, and differentiation. 2D stiff environments cause increased cellular spreading and induce osteogenic differentiation whereas 3D soft environments favor rounder cell morphologies attributed to a chondrogenic phenotype. The goal of this study is to create a composite that integrates these divergent biophysical signals within one system. This composite consists of a stiff and porous polycaprolactone (PCL) backbone that provides mechanical stiffness and a 2D environment. The PCL backbone is then perfused with mesenchymal stem cells (MSCs) and a soft methacrylated gelatin (GelMe) hydrogel to provide …


Design Of A Pneumatic Soft Robotic Actuator Using Model-Based Optimization, Mahsa Raeisinezhad Jun 2021

Design Of A Pneumatic Soft Robotic Actuator Using Model-Based Optimization, Mahsa Raeisinezhad

Theses and Dissertations

In this thesis, the design and optimization process of a novel soft intelligent modular pad (IntelliPad) for the purpose of pressure injury prevention is presented. The structure of the IntelliPad consists of multiple individual multi-chamber soft pneumatic-driven actuators that use pressurized air and vacuum. Each actuator is able to provide both vertical and horizontal motions that can be controlled independently. An analytical modeling approach using multiple cantilever beams and virtual springs connected in a closed formed structure was developed to analyze the mechanical performance of the actuator. The analytical approach was validated by a finite element analysis. For optimizing the …


Investigation Of Single, Binary, And Ternary Metal Oxides Of Iridium, Rhodium, And Palladium For Neural Interfacing Applications, Gregory Vincent Taylor Jun 2021

Investigation Of Single, Binary, And Ternary Metal Oxides Of Iridium, Rhodium, And Palladium For Neural Interfacing Applications, Gregory Vincent Taylor

Theses and Dissertations

In this dissertation, thin film single, binary, and ternary metal oxides of iridium (Ir), ruthenium (Ru), rhodium (Rh), and palladium (Pd) were synthesized for use as electrode/microelectrode coatings for neural interfacing applications using DC reactive magnetron sputtering. Synthesis conditions which enhanced the electrochemical properties of films as measured by cyclic voltammetry and electrochemical impedance spectroscopy in a phosphate buffered saline solution of the single metal oxides were identified to be 30 mTorr working pressure, 20% oxygen partial pressure, and cathode power densities ≤ 4.9 W/cm2. These parameters were then used to develop the binary and ternary metal oxide …


The Matrix Revisited: A Critical Assessment Of Virtual Reality Technologies For Modeling, Simulation, And Training, George Demetrius Lecakes Jun 2021

The Matrix Revisited: A Critical Assessment Of Virtual Reality Technologies For Modeling, Simulation, And Training, George Demetrius Lecakes

Theses and Dissertations

A convergence of affordable hardware, current events, and decades of research have advanced virtual reality (VR) from the research lab into the commercial marketplace. Since its inception in the 1960s, and over the next three decades, the technology was portrayed as a rarely used, high-end novelty for special applications. Despite the high cost, applications have expanded into defense, education, manufacturing, and medicine. The promise of VR for entertainment arose in the early 1990's and by 2016 several consumer VR platforms were released. With VR now accessible in the home and the isolationist lifestyle adopted due to the COVID-19 global pandemic, …


In Situ Characterization Of Fiber-Matrix Interface Debonding Via Full-Field Measurements, Robert Livingston Jun 2021

In Situ Characterization Of Fiber-Matrix Interface Debonding Via Full-Field Measurements, Robert Livingston

Theses and Dissertations

Macroscopic mechanical and failure properties of fiber-reinforced composites depend strongly on the properties of the fiber-matrix interface. For example, transverse cracking behavior and interlaminar shear strength of composites can be highly sensitive to the characteristics of the fiber-matrix interface. Despite its importance, experimental characterization of the mechanical behavior of the fiber-matrix interface under normal loading conditions has been limited. This work reports an experimental approach that uses in situ full-field digital image correlation (DIC) to quantify the mechanical and failure behaviors at the fiber-matrix interface. Single fiber model composite samples are fabricated from a proprietary epoxy embedding a single glass …


An Evaluation Of Electrically Conductive Asphalt Mixtures For Electrically Heated Flexible Pavement Systems, Rahaf Hasan Jun 2021

An Evaluation Of Electrically Conductive Asphalt Mixtures For Electrically Heated Flexible Pavement Systems, Rahaf Hasan

Theses and Dissertations

The goal of this study is to develop Electrically Conductive Asphalt (ECA) mixtures with optimized electrical and mechanical properties for use in electrically heated asphalt pavements for anti-icing applications. Laboratory experiments were carried out to design ECA mixtures at varying dosages, using three graphite grades of different particle sizes, one virgin aggregate type, two binder grades, and one carbon fiber. The impact of graphite dosage and particle size on the volumetric properties and electrical resistivity of asphalt mixtures was assessed. Different factors with potential impact on the electrical properties were investigated, including the graphite particle size and dosage, the air …


Rebalancing Shared Mobility Systems By User Incentive Scheme Via Reinforcement Learning, Matthew Brian Schofield Jun 2021

Rebalancing Shared Mobility Systems By User Incentive Scheme Via Reinforcement Learning, Matthew Brian Schofield

Theses and Dissertations

Shared mobility systems regularly suffer from an imbalance of vehicle supply within the system, leading to users being unable to receive service. If such imbalance problems are not mitigated some users will not be serviced. There is an increasing interest in the use of reinforcement learning (RL) techniques for improving the resource supply balance and service level of systems. The goal of these techniques is to produce an effective user incentivization policy scheme to encourage users of a shared mobility system to slightly alter their travel behavior in exchange for a small monetary incentive. These slight changes in user behavior …


Integrating Vibratory Membrane-Based Water Recovery Systems For Sustainable Food And Beverage Production, Michael Vincent O. Laurio May 2021

Integrating Vibratory Membrane-Based Water Recovery Systems For Sustainable Food And Beverage Production, Michael Vincent O. Laurio

Theses and Dissertations

A vibratory nanofiltration (NF) system was investigated for the preconcentration of coffee extracts for soluble coffee production. The simulated coffee extracts studied contained mostly suspended and colloidal organic components that, although were effectively rejected by the NF membrane (>99% turbidity rejection), affected the vibratory NF performance. The vibratory NF operation improved permeate flux, rejection efficiencies, and reduced flux decline from those observed in crossflow (CF) operation. Further, the effects of applied transmembrane pressure (TMP) and vibrational frequency (F) at corresponding displacement (d) were investigated and modeled. A semi-empirical resistance-in-series model was employed to characterize the mass transfer mechanism, osmotic …


Engineering A Prophylactic Cap For Multi-Dose Vial Disinfection, Rebecca Lee Charboneau May 2021

Engineering A Prophylactic Cap For Multi-Dose Vial Disinfection, Rebecca Lee Charboneau

Theses and Dissertations

Recently, multi-dose vials (MDVs) have demonstrated significant bioburden, with randomized studies revealing bacterial contamination rates up to 27%. When the proper protocol of disinfecting the vial diaphragm with a pre-saturated wipe is followed, MDV bioburden is eliminated. However, when this sterilization protocol is neglected, the susceptibility of MDV to house potential nosocomial pathogens intensifies. In this work, the usability and effectiveness of a novel device, referred to as the Vial Cap, are investigated to gauge the feasibility and acceptability of this device as a method of MDV disinfection. The usability of the Vial Cap was evaluated using principle human factors …


Effects Of Genipin Crosslinking On The Properties Of Tendon Derived Extracellular Matrix Hydrogels, Alicia Cheyenne Coombs May 2021

Effects Of Genipin Crosslinking On The Properties Of Tendon Derived Extracellular Matrix Hydrogels, Alicia Cheyenne Coombs

Theses and Dissertations

Extracellular matrix (ECM) hydrogels are a useful biomaterial in the tissue engineering field used for injectables in drug delivery systems, wound dressing, tissue regeneration and many other applications. ECM hydrogels are highly biocompatible, contain proper ratios of biomolecules required for complex bioactivity of tissues and they promote tissue repair. However, ECM hydrogels typically have poor mechanical strength, which leads to hydrogel instability, and a limitation in their ability to be modified for translational applications. In this research, genipin, a natural crosslinker derived from plants, was utilized in an attempt to improve upon the mechanical limitations of ECM hydrogels. Genipin has …


Numerical Modeling Of The Fiber Deposition Flow In Extrusion-Based 3d Bioprinting, Dhanvanth Jaya Talluri Apr 2021

Numerical Modeling Of The Fiber Deposition Flow In Extrusion-Based 3d Bioprinting, Dhanvanth Jaya Talluri

Theses and Dissertations

Extrusion bioprinting involves the deposition of bioinks in a layer-wise fashion to build 3D structures that mimic natural living systems' behavior in tissue engineering. Hydrogels are the most common bioinks, in which their viscosity properties are dependent on the shear-rate, such as Non-Newtonian fluids. Numerical simulation of extrusion bioprinting may help study the flow properties of hydrogels and designing improved bioinks. In this thesis, the instability caused by the shear-thinning or -thickening parameter during extrusion is numerically compared with the theoretical estimations. The process of fiber deposition of hydrogels onto a substrate through the single and coaxial nozzle is done …


Enhancement Of Electrospun Nanofiber Properties Via Automated Track Post-Draw Processing, David Anthony Brennan Mar 2021

Enhancement Of Electrospun Nanofiber Properties Via Automated Track Post-Draw Processing, David Anthony Brennan

Theses and Dissertations

Electrospinning is an alternative manufacturing method, capable of producing fibers with nanoscale diameters from a wide range of different polymers in a process which is relatively simple and inexpensive in comparison to other forms of nanofiber production. This has made electrospinning the subject a great deal of research as a method of producing nanofibers for various high-performance applications. However, electrospun nanofiber tensile strength is weak in comparison to conventional fibers of the same material, preventing widespread use and marketization. This disparity in mechanical strength is attributed to poor polymer chain alignment in individual fibers, caused by the absence of a …


Dewetting Induced Lipid Bilayer Multicomponent Scaffold For Synthetic Cell Vesicle And Their Stability, Anjana Khanal Feb 2021

Dewetting Induced Lipid Bilayer Multicomponent Scaffold For Synthetic Cell Vesicle And Their Stability, Anjana Khanal

Theses and Dissertations

This thesis introduces a microfluidic method to generate monodisperse water-in-oil-in water double emulsions. The microfluidic method is able to produce double emulsions with high degree of controllability and flexibility on size and number of droplets. We demonstrate this by producing double emulsions containing 1-8 inner water droplets and studied their dewetting phenomena to lipid bilayer scaffold. Our study shows that for the dewetting phenomenon to occur the oil must be volatile, polar and should make low contact angle with the involved interfaces. The chloroform shows self-emulsification behavior in presence of surfactant F127. The topological droplets formation with multiple compartments is …


Establishing A Mechanistic Link Between Disturbed Flow And Aneurysm Formation In A 3d Cerebral Bifurcation Model, Nesrine Bouhrira Feb 2021

Establishing A Mechanistic Link Between Disturbed Flow And Aneurysm Formation In A 3d Cerebral Bifurcation Model, Nesrine Bouhrira

Theses and Dissertations

The effect of disturbed flow profiles on the endothelium have been studied extensively in systemic vasculature, but less is known about the response of the blood-brain barrier (BBB) to these flow regimes. Here we investigate the effect of steady and pulsatile disturbed flow on the integrity of the BBB using a three-dimensional, perfusable bifurcation model consisting of a co-culture of endothelial cells with mural and glial cells. Experimental flow patterns predicted by computational fluid dynamics mimic in vivo flow regimes, specifically the presence of a recirculation zone immediately downstream of the bifurcation reveal periodic changes in the instantaneous shear stress …