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Articles 1 - 3 of 3
Full-Text Articles in Engineering
Brain Motion And Deformation During Closed Head Injury In The Presence Of Cerebrospinal Fluid, Charles F. Babbs
Brain Motion And Deformation During Closed Head Injury In The Presence Of Cerebrospinal Fluid, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Publications
This paper presents a new analysis of the physics of closed head injury following brief, intense acceleration of the head. It focuses upon the buoyancy of the brain in cerebrospinal fluid, which protects against damage, the propagation of strain waves through the brain substance, which causes damage, and the concentration of strain in critical anatomic regions, which magnifies damage. Numerical methods are used to create animations or "movies" of brain motion and deformation. Initially a 1 cm gap filled with cerebrospinal fluid (CSF) separates the brain from the skull. Whole head acceleration induces artificial gravity within the skull. The brain …
Optimizing Chest Compression To Rescue Ventilation Ratios During One-Rescuer Cpr By Professionals And Lay Persons: Children Are Not Just Little Adults, Charles F. Babbs, Vinay Nadkarni
Optimizing Chest Compression To Rescue Ventilation Ratios During One-Rescuer Cpr By Professionals And Lay Persons: Children Are Not Just Little Adults, Charles F. Babbs, Vinay Nadkarni
Weldon School of Biomedical Engineering Faculty Publications
Objective: To estimate the optimum ratio of chest compressions to ventilations for onerescuer CPR that maximizes systemic oxygen delivery in children. Method: Equations describing oxygen delivery and blood flow during CPR as functions of the number of compressions and the number of ventilations delivered over time were adapted from the former work of Babbs and Kern. These equations were solved explicitly as a function of body weight, using scaling algorithms based upon principles of developmental anatomy and physiology. Results: The optimal compression to ventilation (C/V) ratios for infants and younger children increase sharply as a function of body weight. Optimal …
Meta-Analysis Of Two-Treatment Clinical Trials Including Both Continuous And Dichotomous Results, Charles F. Babbs
Meta-Analysis Of Two-Treatment Clinical Trials Including Both Continuous And Dichotomous Results, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Publications
To expedite the timely creation of medical practice guidelines, a meta-analytic method was developed to combine of both dichotomous survival data and continuous physiologic data from multiple studies comparing the same innovative clinical intervention to standard care. The method is adapted for synthesis of small, early studies of novel treatments. An aggregate ratio, R*, of the observed treatment effect to a clinically optimal treatment effect for studies in a series is computed, and compared to the 95% confidence limit for R* under the null hypothesis. Weights assigned to each study may reflect its precision, quality, or clinical relevance. Input data …