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Full-Text Articles in Engineering
Biomimetic Metal-Organic Nanoparticles Prepared With A 3d-Printed Microfluidic Device As A Novel Formulation For Disulfiram-Based Therapy Against Breast Cancer, Ya Chang, Jizong Jiang, Wu Chen, Wen Yang, Lili Chen, Pengyu Chen, Jianzhong Shen, Shizhi Qian, Teng Zhou, Linfeng Wu, Liang Hong, Yongzhuo Huang, Feng Li
Biomimetic Metal-Organic Nanoparticles Prepared With A 3d-Printed Microfluidic Device As A Novel Formulation For Disulfiram-Based Therapy Against Breast Cancer, Ya Chang, Jizong Jiang, Wu Chen, Wen Yang, Lili Chen, Pengyu Chen, Jianzhong Shen, Shizhi Qian, Teng Zhou, Linfeng Wu, Liang Hong, Yongzhuo Huang, Feng Li
Mechanical & Aerospace Engineering Faculty Publications
Disulfiram (DSF) is currently tested in several clinical trials for cancer treatment in combination with cop-per (Cu) ions. Usually, DSF and Cu are administered in two separate formulations. In the body, DSF andCu ions form diethyldithiocarbamate copper complex [Cu(DDC)2] which has potent antitumor activities.However, the “two formulation” approach often achieved low Cu(DDC)2 concentration at tumor regions and resulted in compromised anticancer efficacy. Therefore, preformed Cu(DDC)2 complex administered in a single formulation will have better anticancer efficacy. However, the poor aqueous solubility of Cu(DDC)2 is a significant challenge for its clinical use. In this work, a …