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Changes In Nadph Oxidase (Nox) Protein Isoforms And Downstream Reactions As Function Of Time And Overpressure In Blast Tbi, Smit Prakash Shah
Changes In Nadph Oxidase (Nox) Protein Isoforms And Downstream Reactions As Function Of Time And Overpressure In Blast Tbi, Smit Prakash Shah
Theses
Blast-induced Traumatic brain injury (bTBI) is a leading cause of morbidity in soldiers on the battlefield and training sites with long-term neurological and psychological pathologies. Among many pathological sequela of blast TBI, oxidative stress has been identified as a major factor contributing to the pathophysiology of bTBI. Recent studies have demonstrated activation of oxidative stress pathways following blast injury but their distribution among different brain regions as function of post injury time and Blast over pressure (BOP) have not been explored. The present study examines the protein expression of NADP oxidase (NOX) isoforms 1 & 2, corresponding superoxide production, a …