Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Engineering
A Bipolar Clamp Mechanism For Activation Of Jak-Family Protein Tyrosine Kinases, Dipak Barua, James R. Faeder, Jason M. Haugh
A Bipolar Clamp Mechanism For Activation Of Jak-Family Protein Tyrosine Kinases, Dipak Barua, James R. Faeder, Jason M. Haugh
Chemical and Biochemical Engineering Faculty Research & Creative Works
Most cell surface receptors for growth factors and cytokines dimerize in order to mediate signal transduction. For many such receptors, the Janus kinase (Jak) family of non-receptor protein tyrosine kinases are recruited in pairs and juxtaposed by dimerized receptor complexes in order to activate one another by trans-phosphorylation. An alternative mechanism for Jak trans-phosphorylation has been proposed in which the phosphorylated kinase interacts with the Src homology 2 (SH2) domain of SH2-B, a unique adaptor protein with the capacity to homo-dimerize. Building on a rule-based kinetic modeling approach that considers the concerted nature and combinatorial complexity of modular protein domain …