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Missouri University of Science and Technology

Masters Theses

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Full-Text Articles in Engineering

Development Of A Particulate Matter Sensor Network For Air Quality Monitoring In Indoor Settings And In Mines, Abdulrahman Bani Jan 2024

Development Of A Particulate Matter Sensor Network For Air Quality Monitoring In Indoor Settings And In Mines, Abdulrahman Bani

Masters Theses

"The importance of indoor air quality (IAQ), especially concerning particulate matter (PM), has become increasingly recognized due to its substantial impact on public health. Individuals spend a significant portion of their time indoors, where PM concentrations can exceed that of outdoors, leading to potential adverse health effects ranging from immediate irritation to long-term respiratory and cardiovascular diseases. The dynamic nature of indoor environments, combined with the diversity of PM sources, presents considerable challenges for effective IAQ monitoring and management. Traditional approaches to IAQ assessment often fall short, lacking the granularity and immediacy required to address these challenges adequately.

This abstract …


Laboratory Scale Experimental Analysis Of The Effect Of Surfactants On Acid Mist Suppression During Copper Electrowinning, Thurman Kollie Elgin Jan 2024

Laboratory Scale Experimental Analysis Of The Effect Of Surfactants On Acid Mist Suppression During Copper Electrowinning, Thurman Kollie Elgin

Masters Theses

"The reduction in acid mist generation is an industrial occupational objective in the electrowinning industry of base metals. The technology of electrowinning as an extractive metallurgical technique of metals proficiently contributed to the recovery of pure base metals. During the process of electrowinning, oxygen bubbles are generated on the anode of the electrowinning cell because of the over potential in the cell due to high voltage. The bubbles formed tend to contain sulfuric acid of the electrolyte in the form of liquid-gas ascending particles of the solution. As these bubbles ascend to the surface of the solution, they burst at …


A Binary Integer Linear Programming Model For Optimizing Underground Stope Layout, Theophilus Mensah Jan 2024

A Binary Integer Linear Programming Model For Optimizing Underground Stope Layout, Theophilus Mensah

Masters Theses

"Underground mine planning engineers face significant challenges when determining what geometry provides the most profitable and safe stope for extraction. Several techniques and optimization algorithms have been developed in recent years, but most fail to find optimal solutions because they are heuristic or LP-based without efficient geometric constraints. This thesis work proposes a two-dimensional binary linear programming (BILP) model for determining the optimal combination of blocks in a stope that maximizes the economic value of the layout of stopes for a sublevel deposit. The work draws from Queyranne and Wolsey’s (2017 & 2018) formulations of tight constraints for bounded up/down …


Validation Of Athlet With Purdue University Multi-Dimensional Integral Test Assembly (Puma) Test, Emin Fatih Ozdem Jan 2024

Validation Of Athlet With Purdue University Multi-Dimensional Integral Test Assembly (Puma) Test, Emin Fatih Ozdem

Masters Theses

"Following the Three Mile Island Unit 2 (TMI-2) disaster, the development of a diagnostic system for emergency situations in a nuclear power plant was identified as an essential research area to strengthen the safety of nuclear power plants. A real-time estimation system of vital safety parameters on the main side of a PWR (Pressurized Water Reactor) facility was investigated since precise post-event scenario estimations are thought to be a crucial component of the diagnostic system. The alarm system of the plant can detect an SB-LOCA (Small Break Loss-Of-Coolant-Accident), but there were a couple of potential long-term transient occurrences. The accident …


Low Finesse Extrinsic Fabry-Perot Interferometer (Efpi) Demodulation For High Temperature Gap Measurements, Abhishek Prakash Hungund Jan 2024

Low Finesse Extrinsic Fabry-Perot Interferometer (Efpi) Demodulation For High Temperature Gap Measurements, Abhishek Prakash Hungund

Masters Theses

"In continuous casting steel industries, mold flux is added to provide thermal and chemical insulation for molten steel. The mold flux absorbs detrimental inclusions from the steel and promotes uniform heat distribution to prevent sticking. To promote flux infiltration, mold oscillation is used, but this creates oscillation marks that reduce local shell growth and increase temperatures. Wide (2-3 mm) and deep (0.5-0.9 mm) oscillation marks with areas of 1.1-2.5 mm² are observed, affecting the steel quality, which results in a loss of 6% per billet to the industry. To address this challenge, we propose an extrinsic Fabry-Perot interferometer (EFPI) sensor …


Directed Energy Deposition Processing-Performance Relationship Of Af9628, Mianqing Yang Jan 2024

Directed Energy Deposition Processing-Performance Relationship Of Af9628, Mianqing Yang

Masters Theses

"AF9628 low alloy steel is a novel steel known for its low cost, high hardness, and outstanding tensile performance. However, the processing methods of AF9628 have been less studied in the additive manufacturing field. As the balance of hardness and tensile results is closely related to the cooling process during manufacturing process window and its relationship to resultant tensile properties is explored. By using the DED method, specimens of this steel are successfully fabricated, and tensile test results are obtained. The AF9628 steel can be manufactured for tailored properties with the DED process by controlling the cooling method. This work …


The Graduation Walk: Pareto Optimization Of Degree Paths, Arianna Gail Sy Chaves Jan 2024

The Graduation Walk: Pareto Optimization Of Degree Paths, Arianna Gail Sy Chaves

Masters Theses

"A student’s academic history, course availability at their institution, and the overall degree of difficulty of the schedule for each semester are all critical factors in their academic success and experience. This thesis proposes an advanced recommendation algorithm that considers these real and conflicting factors that are involved in identifying a prudent degree path - a semester-by-semester course schedule to graduation - for each student. The original contribution of this work is the use of weighted-sum multi-objective constraint programming to minimize an increased number of optimization criteria and identify Pareto-optimal degree paths to be recommended to the student. The conflicting …


Characterization Of The Kansas River Alluvial Aquifer Using Towed Transient Electromagnetic Geophysical Method, Jonathon Daniel Voss Jan 2024

Characterization Of The Kansas River Alluvial Aquifer Using Towed Transient Electromagnetic Geophysical Method, Jonathon Daniel Voss

Masters Theses

"Forecasted urban development areas west of Kansas City, Kansas in the coming decades has caused an increase of research into water resources (Butler et al. 2022). A location of investigation has been the Kansas River Alluvial Aquifer (KRAA) for shallow ground water resources. To investigate the KRAA structure and grain texture, the towed transient electromagnetic system (tTEM) in conjunction with direct push electrical conductivity logs and lithology wells were used to investigate four locations between Lawrence and Manhattan, Kansas. In total, 110 line-kilometers of tTEM data was collected. The tTEM data collected were high quality and through inversions of the …


Fiber Assisted Re-Assembly Preformed Particle Gel For Conformance Control, Zhe Sun Jan 2024

Fiber Assisted Re-Assembly Preformed Particle Gel For Conformance Control, Zhe Sun

Masters Theses

"In Enhanced Oil Recovery technology today, gel treatments have been implemented as a cost-effective method to improve the oil sweep efficiency in reservoirs by plugging the high permeability zones. This study presents a novel gel composition to be used in conformance control in order to improve oil recovery for mature oilfields.

The product is a fiber-assist re-assembly preformed particle gel which could be generalized to the preformed particle gels (PPG). The product developed in this study could be injected into the reservoir act as a conformance control agent by plugging water thief zones and channels in the beginning process. Due …


High-Pressure Infiltration Process For Additively Manufactured Ceramic Matrix Composites, Samuel Weiler Jan 2024

High-Pressure Infiltration Process For Additively Manufactured Ceramic Matrix Composites, Samuel Weiler

Masters Theses

"Ceramic matrix composites were developed in order to increase the fracture toughness, thermal shock resistance, and elongation of ceramic materials, while maintaining the very high temperature capabilities of these materials. A renewed focus has been placed on ceramic matrix composites due to the need for materials that maintain good mechanical strength at very high temperatures, for use in the extreme environments encountered by hypersonic vehicles, jet turbine blades, and the like. However, conventional methods to manufacture CMCs are costly and time consuming. The aim of this work is to develop a method for creating additively manufactured ceramic matrix composites using …


Processing & Properties Of Zirconium Carbide Manufactured By Ceramic On-Demand Extrusion, Clare Sabata Jan 2024

Processing & Properties Of Zirconium Carbide Manufactured By Ceramic On-Demand Extrusion, Clare Sabata

Masters Theses

"This research focuses on the development of a zirconium carbide (ZrC) paste for use in material extrusion direct ink write additive manufacturing (AM) followed by the pressure less densification of ZrC and the mechanical and thermal characterization of the resulting ceramics. A highly loaded, aqueous paste was developed using commercial ZrC powder ball milled to ~1 μm. Optimal dispersant, binder, and solids loading were found by rheological characterization. The paste composition consisted of 46-47 vol% ZrC, 43.5 vol% distilled water, 8.1 vol% dispersant, and 1.6 vol% binder. A yield stress of ~8 Pa allowed for shape retention upon removal of …


Discrete Event Simulation (Des) In Swapping/Charging Of Battery Electric Vehicles In Underground Mining, Albert Einstein Amponsem Jan 2024

Discrete Event Simulation (Des) In Swapping/Charging Of Battery Electric Vehicles In Underground Mining, Albert Einstein Amponsem

Masters Theses

"With climate change concerns escalating, international agreements such as the Kyoto Protocol, the US Presidential Policy, and the Paris Agreement aim to reduce greenhouse gas (GHG) emissions, targeting significant reductions by 2050. The mining sector, a notable contributor to GHG emissions primarily through diesel-powered material haulage, emits approximately 68 million tons of CO2 annually. Transitioning to Battery Electric Trucks (BETs) presents a viable mitigation strategy by replacing diesel trucks with electric alternatives, thus eliminating CO2 emissions.

However, the effectiveness of BETs hinges on optimized battery swapping and charging procedures. This study employs Discrete Event Simulation (DES), a computational …


Human Arm Stiffness Estimation Method Developed For Overground Physical Interaction Experiments: Experimental Validation And Perspectives For Future Applications, Tarani Kanth Kamma Jan 2024

Human Arm Stiffness Estimation Method Developed For Overground Physical Interaction Experiments: Experimental Validation And Perspectives For Future Applications, Tarani Kanth Kamma

Masters Theses

"To build a physically interactive robot for overground applications, it is crucial to first understand the biomechanics of humans underlying overground physical human-robot interaction (pHRI) tasks. Estimating human arm stiffness during overground interactive tasks is a promising first step toward this goal. For this, an arm stiffness estimation technique was developed in our previous works that consider the unique challenges involving overground pHRI, such as the need to estimate the arm stiffness from a short duration of data with fewer repetitions. In this work, our stiffness estimation method is further validated with a passive spring setup with known stiffness values, …


Groundwater Movement In Boiling Spring, Onyx Spring, Yelton Spring, Wilkins Spring, Hudgens Spring And Natural Bridge Spring, Katherin Roxana Montes Chamorro Jan 2024

Groundwater Movement In Boiling Spring, Onyx Spring, Yelton Spring, Wilkins Spring, Hudgens Spring And Natural Bridge Spring, Katherin Roxana Montes Chamorro

Masters Theses

"Onyx Spring, Boiling Spring, Yelton Spring, Wilkins Spring, Hudgens Spring, and Natural Spring are located on public land in Pulaski and Phelps County, Missouri. They were selected randomly to determine groundwater movement and compare water chemistry from the springs that are connected.

Using a dye tracing method, we were able to determine the direction of groundwater flow and a water multiparameter sonde was used to characterize the water chemistry at each point of the springs. As a result, from the six springs studied only three springs are connected which are Yelton, Onyx and Boiling Spring. Regarding to water chemistry this …


Computational Fluid Dynamics Analysis Of Thermal-Hydraulic Phenomena In Nuclear Reactor Systems, Mehedi Hasan Tusar Jan 2024

Computational Fluid Dynamics Analysis Of Thermal-Hydraulic Phenomena In Nuclear Reactor Systems, Mehedi Hasan Tusar

Masters Theses

"A computational analysis of thermal-hydraulic processes in nuclear reactor systems is performed, leveraging Computational Fluid Dynamics (CFD) to advance the design and ensure the safety of nuclear reactors. Divided into two primary sections, the initial part examines thermal-hydraulic behavior in the Replacement Research Reactor (RRR) operating at 20 megawatts and evaluates potential enhancements for the Missouri University of Science and Technology Reactor (MSTR) to operate at an increased capacity of 2 megawatts from the existing 0.2 megawatts. Detailed simulations reveal insights into flow characteristics, temperature distributions, and pressure drops, highlighting the effective use of realistic and porous media modeling techniques …


Fe-Ni-Cu-Pge Sulfide Transport Mechanisms And Carbon-Sulfur Interactions In Lower Crustal Magmatic Settings: A Study From The Valmaggia Ultramafic Pipe, Ivrea-Verbano Zone, Italy, Shelby Leann Clark Jan 2024

Fe-Ni-Cu-Pge Sulfide Transport Mechanisms And Carbon-Sulfur Interactions In Lower Crustal Magmatic Settings: A Study From The Valmaggia Ultramafic Pipe, Ivrea-Verbano Zone, Italy, Shelby Leann Clark

Masters Theses

"Constraining the processes that control the transport and deposition of sulfides in the deep lithosphere is an important step in expanding ore deposit exploration search space to include exhumed lower crustal rocks. The ultramafic sulfide ore-bearing Valmaggia pipe in the Ivrea-Verbano Zone of NW Italy, an exhumed cross section of the overlying lower continental crust and subcontinental lithospheric mantle, gives critical insight into metallogenic processes in lower crustal settings. The ~300 m wide metasomatized pipe hosts Fe-Ni-Cu-(PGE±Co±Au) sulfide mineralization that is commonly associated with locally abundant carbonates and hydrous silicates (phlogopite, amphibole). Previous studies suggested that sulfides were physically transported …


Theoretical Modeling And Experimental Investigation Of Phase Selection During Rapid Solidification Of Alloys, Azeez Aremu Akinbo Jan 2024

Theoretical Modeling And Experimental Investigation Of Phase Selection During Rapid Solidification Of Alloys, Azeez Aremu Akinbo

Masters Theses

"A novel model, rooted in time-dependent nucleation theory, has been created to explore how rapid solidification affects the extended solubility in metal alloys. This model was used to forecast solubility concerning undercooling in multiple binary aluminum (Al) alloys, and its predictions for both eutectic and peritectic systems closely match experimental data. It was demonstrated that this developed model surpasses the T0 line method, which does not consider the kinetic aspects of nucleation. Furthermore, the model can be extended to ternary and multicomponent phases by assuming that the scarcest element or the slowest diffusing component restricts nucleation. Al-Cu and Al-Cr, vital …


Dig Limits Optimization Using Binary Integer Linear Programming Method In Open Pit Mines, Hussam Naif Altalhi Jan 2024

Dig Limits Optimization Using Binary Integer Linear Programming Method In Open Pit Mines, Hussam Naif Altalhi

Masters Theses

"Dig limits optimization is the process for classifying different materials (e.g., ore, stockpile material, and waste) into appropriately sized contiguous zones for open pit mining. The efficient determination of dig-limits is crucial for profitable and sustainable resource extraction in mining. Previous research has focused on defining dig-limits manually or using optimization approaches, but these methods are limited to only handling two material destinations (ore and waste). Thus, there is a need for operations research methods that consider the selectivity of mining equipment and can optimize dig-limits for metal mining operations with more than two material destinations. Consequently, the objective of …


Investigation Of The Relationships Between Hydraulic, Physical, And Biological Soil Parameters At A Vineyard In Saint James, Missouri, Lyndsey Bennett Jan 2024

Investigation Of The Relationships Between Hydraulic, Physical, And Biological Soil Parameters At A Vineyard In Saint James, Missouri, Lyndsey Bennett

Masters Theses

"Soil is a living, dynamic system that performs vital functions such as crop production, organic matter decomposition, and the flow and transport of water. Given the pressures of food and in some locales water security, climate change, and sustainability, farmers, scientists, and other related specialists and stakeholders must have access to understandable soil health indicators as well as the soil hydraulic function parameters to maximize crop growth while maintaining soil health. Although biological and physical soil parameters are different, we aim to evaluate their relationship at the field scale. Hydraulic conductivity in the vadose zone may be especially important, as …


High Strain Rate Analysis Of 3d Printed Concrete As Compared To Conventionally Cast Concrete, Weston Mcleod Thomsen Jan 2024

High Strain Rate Analysis Of 3d Printed Concrete As Compared To Conventionally Cast Concrete, Weston Mcleod Thomsen

Masters Theses

"3D Printed Concrete (3DPC) is a developing method of construction that has advantages over conventional methods, including formwork reduction, complex geometry, and expedited construction. This technology has potential benefits for the military when considering the austere environments that forward operating bases are built in. This study aims to assess 3DPC applications in protective structures that protect critical assets from explosive blasts. These protective structures experience a high-strain rate response during blast loading of the structure, and the effects of this have yet to be analyzed in the literature concerning 3DPC. With the lack of prior research, the focus here will …


Open-Ended Hollow Coaxial Cable Resonance Sensing Via Permittivity Fluctuations For Applications To Exhaled Breath Health Monitoring, Peter Henry Holtmann Jan 2024

Open-Ended Hollow Coaxial Cable Resonance Sensing Via Permittivity Fluctuations For Applications To Exhaled Breath Health Monitoring, Peter Henry Holtmann

Masters Theses

"We report a pre-diagnostics breath analyzer based on the open-ended hollow coaxial cable resonator (OE-HCCR) to achieve real-time differentiation of healthy and compromised lung function through electromagnetic analysis of exhaled breath matter. A two-phase amplification scheme of electromagnetic signatures metered via the S11 phase curve offers high sensitivity to permittivity fluctuations in exposed airflow. The mathematical model of the breath analyzer is explained, followed by experimental validation of numerical findings from previous work. The collection of breath transient signals is performed through monitoring the reflected power magnitude and phase of the scattering parameter (S11) at the resonance frequency. Material fluctuations …


Production Of Glass-To-Metal Seals Using Additive Manufacturing Techniques, Aaron Read Jan 2024

Production Of Glass-To-Metal Seals Using Additive Manufacturing Techniques, Aaron Read

Masters Theses

"Glass-to-metal (GtM) seals are hermetic barriers between glass and metal components, often used in the electronic and vacuum industries. Creating the seals traditionally requires heating all the components to the glass melting temperature, where the glass will flow and bond to the metal. Due to the manufacturing constraints of the individual components and sealing conditions there are geometric and material restrictions. Additive manufacturing techniques were used to make GtM seals to reduce these restrictions.

Hermetic, single pin seals were produced using printed metal shells, by selective laser melting (SLM), and digital light processing (DLP) printed glass preforms. Glass preforms were …


Microwave Materials Characterization Of Geopolymers, Jared Sinkey Jan 2024

Microwave Materials Characterization Of Geopolymers, Jared Sinkey

Masters Theses

"The purpose of this work was to develop a process for studying geopolymer materials using a microwave materials characterization approach. Such an approach is known to provide information about chemical and physical properties of materials. As such, in this work, the focus is on the role of water in the geopolymer curing process. To do this, specimens were prepared and cast and microwave measurements conducted throughout the curing process using a short-circuited rectangular waveguide (SC-RWG) measurement technique. In this technique, the complex reflection properties/coefficient of the sample are measured. The effect of sample length and dielectric properties on materials characterization …


Investigating Accident-Tolerant Cladding In A Molten Salt-Cooled Micro-Reactor Using Multi-Physics Analysis And Uncertainty Quantification, Alexander Niles Foutch Jan 2024

Investigating Accident-Tolerant Cladding In A Molten Salt-Cooled Micro-Reactor Using Multi-Physics Analysis And Uncertainty Quantification, Alexander Niles Foutch

Masters Theses

"Renewed interest in nuclear safety has resulted in development of accident-tolerant materials, such as cladding. Although developed for light water reactors, their use in more advanced reactors would save time and development costs for other new materials. This paper performed a Multiphysics investigation into the power profile, thermodynamics, heat transfer, and tensor mechanics of four candidate materials (Haynes 230, Zircaloy-4, FeCrAl, and SiC-SiC), using the highly benchmarked Kilo power design as an example of a high-temperature, highly enriched, sodium-cooled microreactor environment.

From neutronic code MCNP, no significant difference in power profile was found among the four. Using finite element software …


Evaluating Electromagnetic Interference On Gnss Receivers, Giorgi Tsintsadze Jan 2024

Evaluating Electromagnetic Interference On Gnss Receivers, Giorgi Tsintsadze

Masters Theses

"Due to high power and efficiency requirements of modern electrical drive system, inverters are utilizing fast-edge pulses as a drive signal. The high frequency pulses contain higher order harmonics can radiate electromagnetic interference above accepted levels. Modelling and understanding the mechanism that causes the radiation is studied, modelled and presented as gray-box model which contains circuit level modelling of coupling between electrical machine phase windings and low power sensor harness. The thesis consists of two main papers. In the first paper, radiated emissions from an electrical drive system is charac- terized thru gray-box modelling where coupling between electrical machine phase …


Sub-Critical Crack Growth And Fatigue Behaviour Of Alkali Silicate Glass, Noah Weyrauch Jan 2024

Sub-Critical Crack Growth And Fatigue Behaviour Of Alkali Silicate Glass, Noah Weyrauch

Masters Theses

"Delayed failure in silicate glasses can be linked to subcritical crack growth (SCCG) where surface defects grow over time until catastrophic failure. This phenomenon originates from stress-enhanced chemical interactions between the environment (e.g. water) and the strained silicate bonds at the crack tip. SCCG must be accounted for to predict the long-term survivability of silicate-glass components. This study compares two methods to measure SCCG parameters for a commercial alkali silicate sealing glass and for a series of binary xNa2O-(1-x)SiO2 glasses, where 0.15 ≤ x ≤ 0.35. A constant moment double cantilever beam (DCB) technique was used to …


Iterative Power Flow Control Architecture For Dc-Ac-Ac Triple Active Bridge Converters: Design, Simulation, And Hardware Testing, Jonathan Henri Saelens Jan 2024

Iterative Power Flow Control Architecture For Dc-Ac-Ac Triple Active Bridge Converters: Design, Simulation, And Hardware Testing, Jonathan Henri Saelens

Masters Theses

Driven by widespread electrification and escalating energy demands, efficient and cost-effective converter systems are necessary to maintain and improve our nation's electrical grid. Facilitating this necessity are power electronic converters in applications such as smart grids, renewable energy integration, and electric vehicles. Guided by the demand for improved converter topologies and conversion efficiency, much research has been conducted on varying designs, development, and control implementations. One such topology gaining significant research attention is the triple active bridge (TAB) converter. The TAB is a three-port power converter enabling both bidirectional power flow on each port and galvanic isolation for safety and …


A Network Of Low-Cost Multi-Pollutant Air Quality Sensors For Evaluating Fine-Scale Exposure Disparity In Twin Cities, Mn, P M Varuni Abhayaratne Jan 2023

A Network Of Low-Cost Multi-Pollutant Air Quality Sensors For Evaluating Fine-Scale Exposure Disparity In Twin Cities, Mn, P M Varuni Abhayaratne

Masters Theses

"Poor air quality is detrimental to health and is a leading environmental risk factor for early death globally. The massive scale of urbanization and population growth has led urban air quality to become a global concern as the release of air pollutants into the atmosphere continues to increase. Air quality has traditionally been monitored using reference-grade monitoring stations that are expensive and sparsely distributed. Low-cost sensors can complement existing regulatory networks to provide more spatial detail, capturing fine-scale variations. This study investigates spatiotemporal pollutant patterns, exposure disparities and environmental justice using data collected from a two-year (2019-2021) deployment of a …


Flight Software Development For A University-Class Microsatellite Mission, Yumeka Nagano Jan 2023

Flight Software Development For A University-Class Microsatellite Mission, Yumeka Nagano

Masters Theses

"The purpose of this research is to present the software development process used by the Command and Data Handling (C&DH) subsystem as a part of a microsatellite mission underway at the Missouri University of Science and Technology. The mission's objective is to evaluate the performance of an innovative cold gas propulsion system for use in formation flying applications and the incorporation of a stereoscopic imaging sensor used to measure the satellite pair's relative position and velocity vectors in real time. C&DH uses a Raspberry Pi 3 Model B as the flight computer running a Linux environment, and the flight code …


Scalable And Continuous Fabrication Of Dendrimer Based Gene And Protein Delivery Systems, Joseph Johnston Jan 2023

Scalable And Continuous Fabrication Of Dendrimer Based Gene And Protein Delivery Systems, Joseph Johnston

Masters Theses

"Gene and protein therapeutics play critical roles in the drug market and represent the future of biopharmaceuticals. Polymeric nanoparticle-based gene/protein delivery systems are promising owing to their ability to protect the cargo from degradation, improving intracellular delivery and transfection efficiency as well as abundant sources and flexibility to be modified. Yet the successful industrialized production and clinical application of polymeric nanoparticle-based delivery systems have long been limited by unsatisfied delivery efficiency and the lack of reproducible and scalable methods for the preparation of uniform nanoparticles with good batch to batch consistency. To address the unsatisfied efficacy and difficulty in scale-up …